Találati lista | Tudóstér

001-es BibID:	BIBFORM135896
Első szerző:	Fésüs Adina (gyógyszerész)
Cím:	Evaluation of Antibiotic Use in Patients Admitted to a Hungarian Intensive Care Unit with Pneumonia and Sepsis : retrospective Observational Before-After Study / Adina Fésüs, Zsanett Szilágyi, Zsuzsa Beniczky, Eszter Varga, Mária Matuz, Krisztina Gaál, Sándor Somodi, Ildikó Bácskay, István Lekli, Attila Vaskó
Dátum:	2026
Megjegyzések:	Background: Early and adequate empiric antibiotic therapy is essential in the treatment of pneumonia and sepsis and may influence the clinical outcome. Aims and Objectives: This retrospective before?after study aimed to appraise the impact of a local Antibiotic Stewardship Program (ASP?written guidelines and antibiotic restriction) on antibiotic (AB) use and clinical outcomes in patients requiring intensive care due to pneumonia and sepsis. Methods: This study was conducted as a single-center, retrospective observational study in the intensive care unit (ICU) of a pulmonology department of a tertiary care center. Data were collected for the pre-intervention period between January 2018 and May 2022 and for the ASP period between June 2022 and March 2024. In addition to descriptive statistics and univariable methods, interrupted time series (ITS) analysis was used to assess AB use and length of stay in the ICU before and after ASP implementation, using a segmented linear regression with a fixed breakpoint and continuous (hinge) specification. Results: The patients admitted to the ICU with pneumonia and sepsis were mainly men (58/101, 57.4% and 84/128, 65.6%), the need for intensive care increased with age, and most of the patients belonged to 65+ age group in both study phases (69/101, 68.3% and 75/128, 58.6%). The majority of the patients had four or more comorbidities (58/101, 57.4% and 52/128, 40.6%). In-hospital mortality was relatively high (42.6% and 41.4%), with most of the patients losing their lives in the ICU (33/43, 76.7% and 37/53, 69.8%). Significant increase in guideline-adherent agent selection (34.5%) and use of combination therapy (35.0%) was observed, while the use of fluoroquinolones decreased significantly (?31.1%). In the after period, a significant decrease in the number of patients using restricted ABs (?53.3%) was observed. In one-third of these cases (10/34, 29.4% and 16/40, 40%), two to four multidrug-resistant pathogens (MDRs) were detected simultaneously, resulting in a significant increase in direct costs (10.5%) in the ICU. The inappropriate use of AB therapy was relatively low in the presence of MDRs in both phases (2/34, 5.9% and 6/40, 15%). In the ASP period, guideline adherence was associated with slightly better clinical outcomes (30-day mortality: ?0.8%; length of stay: ?22.6%) in pneumonia and sepsis. The ITS analyses after the ASP implementation showed a weak downward trend and before it a slight increasing trend. Conclusions: ASP implementation in the ICU resulted in a significant improvement in the appropriate use of ABs, and guideline adherence led to slightly better clinical outcomes. Our results suggest that ASP may offer improved antimicrobial resistance with a sustained long-term effect.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk antibiotic guideline-adherent length of stay MDR pathogen pneumonia sepsis 30-day mortality
Megjelenés:	Antibiotics. - 15 : 3 (2026), p. 1-21. -
További szerzők:	Szilágyi Zsanett (2001-) (gyógyszerész) Beniczky Zsuzsa Varga Eszter (1992-) (gyógyszerész) Matuz Mária Gaál Krisztina (1976-) (belgyógyász szakorvos) Somodi Sándor (1977-) (belgyógyász) Bácskay Ildikó (1969-) (gyógyszerész, gyógyszertechnológus) Lekli István (1981-) (gyógyszerész) Vaskó Attila (1976-) (tüdőgyógyász)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM050268
Első szerző:	Lőrincz Hajnalka (biológus)
Cím:	Strong correlations between circulating chemerin levels and lipoprotein subfractions in nondiabetic obese and nonobese subjects / Hajnalka Lőrincz, Mónika Katkó, Mariann Harangi, Sándor Somodi, Krisztina Gaál, Péter Fülöp, György Paragh, Ildikó Seres
Dátum:	2014
ISSN:	0300-0664
Megjegyzések:	OBJECTIVE: Chemerin is a recently described adipokine expressed primarily in the white adipose tissue. Compared with lean subjects, circulating chemerin levels are significantly elevated in obese individuals and correlate positively with the prevalence of various cardiovascular risk factors including altered lipoprotein levels. To date, the impact of chemerin on lipoprotein subfractions and its role in atherosclerotic processes are still unclear. PATIENTS AND METHODS: Fifty nondiabetic obese (NDO) patients and 38 lean controls matched in age and gender were enrolled. Chemerin level was measured by ELISA. Low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subfractions were detected by nongradient polyacrylamide gel electrophoresis (Lipoprint). RESULTS: We detected significantly higher serum chemerin levels in NDO patients compared with healthy controls (590·1 ± 190·3 ng/ml vs 405 ± 127·1 ng/ml, P < 0·001). A significant positive correlation was found between chemerin and LDL cholesterol levels, while chemerin showed a significant negative correlation with the level of HDL cholesterol. Significant positive correlation was detected between chemerin and the ratio of small dense LDL, while chemerin correlated negatively with the mean LDL size. Also, a significant negative correlation was found between serum chemerin and the ratio of large HDL subfraction, while there were significant positive correlations between chemerin levels and intermediate and small HDL subfraction ratios, respectively. CONCLUSION: Chemerin may be involved in the regulation of lipoprotein metabolism in obese patients who do not show apparent abnormalities of glucose metabolism. Early changes in the distribution of the lipoprotein subfractions may contribute to the progression of atherosclerosis, leading to increased cardiovascular risk.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban nondiabetic obese Low-density lipoprotein LDL cholesterol
Megjelenés:	Clinical Endocrinology. - 81 : 3 (2014), p. 370-377. -
További szerzők:	Katkó Mónika (1980-) (biológus) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Somodi Sándor (1977-) (belgyógyász) Gaál Krisztina (1976-) (belgyógyász szakorvos) Fülöp Péter (1974-) (belgyógyász, endokrinológus, lipidológus) Paragh György (1953-) (belgyógyász) Seres Ildikó (1954-) (biokémikus)
Pályázati támogatás:	TÁMOP-4.2.2.A-11/1/KONV-2012-0031 TÁMOP 84196 OTKA
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM064365
Első szerző:	Seres Ildikó (biokémikus)
Cím:	Associations of chemerin levels and lipid subfractions in non-diabetic obese and lean subjects / I. Seres, H. Lorincz, M. Katkó, M. Harangi, S. Somodi, K. Gaál, P. Fülöp, G. Paragh
Dátum:	2014
ISSN:	0021-9150
Tárgyszavak:	Orvostudományok Egészségtudományok idézhető absztrakt
Megjelenés:	Atherosclerosis. - 235 (2014), p. e220. -
További szerzők:	Lőrincz Hajnalka (1986-) (biológus) Katkó Mónika (1980-) (biológus) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Somodi Sándor (1977-) (belgyógyász) Gaál Krisztina (1976-) (belgyógyász szakorvos) Fülöp Péter (1974-) (belgyógyász, endokrinológus, lipidológus) Paragh György (1953-) (belgyógyász)
Pályázati támogatás:	TÁMOP-4.2.2.A-11/1/KONV-2012-0031 TÁMOP OTKA 84196 OTKA
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM130932
035-os BibID:	(Scopus)105011533471 (WoS)001535723700001
Első szerző:	Varga Eszter (gyógyszerész)
Cím:	Evaluation of the Diagnosis and Antibiotic Therapy of Sepsis in the Emergency Department: A Retrospective Observational Study / Eszter Varga, Sándor Somodi, Máté Molnár, Dóra Ujvárosy, Krisztina Gaál, Attila Vaskó, Zoltán Szabó, Ildikó Bácskay, István Lekli, Adina Fésüs
Dátum:	2025
ISSN:	2227-9059
Megjegyzések:	Background/Objectives: Sepsis is one of the most common causes of death worldwide, and its diagnosis remains a challenge for clinicians. The main purpose of this study was to appraise the diagnosis and antibiotic prescription pattern for sepsis admitted to the Emergency Department (ED), comparing Sepsis-2 to Sepsis-3 criteria. Methods: The study was conducted in an ED of a tertiary care medical center in Hungary. We included all adult patients who were diagnosed with sepsis in 2023. Data collection was made manually from UD MED System. Diagnosis was assessed based on Sepsis-2 and Sepsis-3 criteria, then compared. Further analyses were made only in cases with confirmed sepsis diagnosis. Antibiotic guideline adherence was determined according to the local guideline in force. Fisher's exact test, t-test, and ANOVA were applied to compare categorical and continuous variables between groups. The Kaplan-Meier test was applied for probability of survival. Significant p-values were defined as below 0.05. Results: The substantial majority of patients recorded with sepsis in the ED met both the Sepsis-2 and Sepsis-3 criteria (80%), while the rate of misdiagnosis was similar (Sepsis-2: 16/91, 17.6% and Sepsis-3: 14/91, 15.4%). The most important identified risk factors in sepsis were old age (60+ years) and comorbidities (CCI >= 4). Elevated LDH (median 325 mg/dL) and decreased albumin levels (median 26 g/L) can be used as early indicators of sepsis. Although the time to first antibiotic administration was not associated with significantly better clinical outcomes, the guideline-adherent agent selection (Sepsis-2: 18/43, 41.9% and Sepsis-3: 19/46: 41.3%) led to a significantly longer survival (median 37 vs. 4 days). Conclusions: No significant differences were found in diagnostic accuracy or prediction of mortality between Sepsis-2 and Sepsis-3. Guideline-adherent antibiotics may lead to significantly higher survival rate in sepsis.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk albumin level antibiotic guideline adherent length of stay risk factors sepsis survival 30-day mortality
Megjelenés:	Biomedicines. - 13 : 7 (2025), p. 1566. -
További szerzők:	Somodi Sándor (1977-) (belgyógyász) Molnár Máté Ujvárosy Dóra (1985-) Gaál Krisztina (1976-) (belgyógyász szakorvos) Vaskó Attila (1976-) (tüdőgyógyász) Szabó Zoltán (1973-) (belgyógyász, kardiológus) Bácskay Ildikó (1969-) (gyógyszerész, gyógyszertechnológus) Lekli István (1981-) (gyógyszerész) Fésüs Adina (1978-) (gyógyszerész)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: