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001-es BibID:	BIBFORM129637
035-os BibID:	(scopus)105004462224 (wos)001483772000001
Első szerző:	Artika, I. Made
Cím:	RNA modifications and their role in gene expression / Artika I. Made, Arianti Rini, Demény Máté Á., Kristóf Endre
Dátum:	2025
ISSN:	2296-889X
Megjegyzések:	Post-transcriptional RNA modifications have recently emerged as critical regulators of gene expression programs. Understanding normal tissue development and disease susceptibility requires knowledge of the various cellular mechanisms which control gene expression in multicellular organisms. Research into how different RNA modifications such as in N6 methyladenosine (m6A), inosine (I), 5-methylcytosine (m5C), pseudouridine (?), 5-hydroxymethylcytosine (hm5C), N1-methyladenosine (m1A), N6,2·-O dimethyladenosine (m6Am), 2·-O-methylation (Nm), N7-methylguanosine (m7G) etc. affect the expression of genes could be valuable. This review highlights the current understanding of RNA modification, methods used to study RNAmodification, types of RNA modification, and molecular mechanisms underlying RNA modification. The role of RNA modification in modulating gene expression in both physiological and diseased states is discussed. The potential applications of RNA modification in therapeutic development are elucidated.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk RNA RNA modification epitranscriptomics gene expression RNA editing therapeutic development
Megjelenés:	Frontiers in Molecular Biosciences. - 12 (2025), p. 1-19. -
További szerzők:	Arianti, Rini (1991-) (biokémikus) Demény Máté Ágoston (1976-) (molekuláris biológus) Kristóf Endre (1987-) (általános orvos)
Pályázati támogatás:	FK145866 OTKA K147482 OTKA PD146202 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM103477
035-os BibID:	(WoS)000851847700001 (Scopus)85137797604
Első szerző:	Nurcholis, Waras
Cím:	Effects of Methods and Durations of Extraction on Total Flavonoid and Phenolic Contents and Antioxidant Activity of Java Cardamom (Amomum compactum Soland Ex Maton) Fruit / Nurcholis Waras, Alfadzrin Rahma, Izzati Nurul, Arianti Rini, Vinnai Boglárka Ágnes, Sabri Fadillah, Kristóf Endre, Artika I. Made
Dátum:	2022
ISSN:	2223-7747
Megjegyzések:	Free radicals contribute to the pathophysiology of degenerative diseases which increase mortality globally, including mortality in Indonesia. Amomum compactum Soland. Ex Maton fruit from the Zingiberaceae family, also known as Java cardamom, contains secondary metabolites that have high antioxidant activities. The antioxidant activity of the methanol extract of Java cardamom fruit correlates with its flavonoid and phenolic compound contents, which can be affected by different methods and durations of extraction. This study aimed to measure and compare the effects of extraction methods and durations on total flavonoid and phenolic contents (TFCs and TPCs) and subsequent antioxidant activities by the 2,2·-diphenyl-1-picrylhydrazyl (DPPH) radical, ferric reducing antioxidant power (FRAP), 2,2·-azino-bis(3-ethylbenzothiazoline-6-sulfonate) (ABTS), and cupric ion reducing antioxidant capacity (CUPRAC) assays. Methanol extracts of Java cardamom were produced by continuous shaking (CSE), microwave-assisted (MAE), or ultrasonic-assisted extractions (UAE) for three different durations. CSE for 360 min resulted in the highest TFCs (3.202 mg Quercetin Equivalent/g dry weight), while the highest TPCs (1.263 mg Gallic Acid Equivalent/g dry weight) were obtained by MAE for 3 min. Out of the investigated methods, MAE for 3 min resulted in the highest antioxidant activity results for the extracts. We conclude that the polyphenolic antioxidant yield of Java cardamom depends on two parameters: the method and the duration of extraction.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Plants-Basel. - 11 : 17 (2022), p. 1-13. -
További szerzők:	Alfadzrin, Rahma Izzati, Nurul Arianti, Rini (1991-) (biokémikus) Vinnai Boglárka Ágnes (1996-) (molekuláris biológus) Sabri, Fadillah Kristóf Endre (1987-) (általános orvos) Artika, I. Made
Pályázati támogatás:	FK131424 OTKA ÚNKP-21-3-I-DE-79 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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