Találati lista | Tudóstér

001-es BibID:	BIBFORM129334
035-os BibID:	(Scopus)85183790814 (wos)001157075100001
Első szerző:	Ramos, Susana
Cím:	Targeting circulating labile heme as a defense strategy against malaria / Ramos Susana, Jeney Viktoria, Figueiredo Ana, Paixao Tiago, Sambo Maria Rosário, Quinhentos Vatúsia, Martins Rui, Gouveia Zélia, Carlos Ana Rita, Ferreira Ana, Pais Teresa F., Lainé Hugo, Faísca Pedro, Rebelo Sofia, Cardoso Silvia, Tolosano Emanuela, Penha-Goncalves Carlos, Soares Miguel P.
Dátum:	2024
ISSN:	2575-1077
Megjegyzések:	Severe presentations of malaria emerge as Plasmodium (P.) spp. parasites invade and lyseredbloodcells (RBC), producing extracellular hemoglobin (HB), from which labile heme is released. Here,wetestedwhetherscavengingofextracellularHB and/or labile heme, by haptoglobin (HP) and/or hemopexin (HPX), respectively, counter the pathogenesis of severe presentations of malaria. We found that circulating labile heme is an independent risk factor for cerebral and non-cerebral presentations of severe P. falciparum malaria in children. Labile heme was negatively correlated with circulating HP and HPX, which were, however, not risk factors for severe P. falciparummalaria.GeneticHpand/orHpxdeletioninmiceledto labile heme accumulation in plasma and kidneys, upon Plasmodiuminfection. Thiswasassociatedwithhigherincidenceof mortality and acute kidney injury (AKI) in ageing but not adult Plasmodium-infected mice, and was corroborated by an inverse correlation between heme and HPX with serological markers of AKI in P. falciparum malaria. In conclusion, HP and HPX act in an age-dependent manner to prevent the pathogenesis of severe presentation of malaria in mice and presumably in humans.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Life Science Alliance. - 7 : 4 (2024), p. 1-20. -
További szerzők:	Jeney Viktória (1971-) (vegyész, kémia tanár) Figueiredo, Ana Paixǎo, Tiago Sambo, Maria Rosário Quinhentos, Vatúsia Martins, Rui Gouveia, Zélia Carlos, Ana Rita Ferreira, Ana Pais, Teresa F. Lainé, Hugo Faísca, Pedro Rebelo, Sofia Cardoso, Sílvia Tolosano, Emanuela Penha-Goncalves, Carlos Soares, Miguel P.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM078365
035-os BibID:	(WoS)000461679000073 (Scopus)85063288166 (PMID)30833408
Első szerző:	Ramos, Susana
Cím:	Renal control of disease tolerance to malaria / Susana Ramos, Ana Rita Carlos, Balamurugan Sundaram, Viktoria Jeney, Ana Ribeiro, Raffaella Gozzelino, Claudia Bank, Erida Gjini, Faouzi Braza, Rui Martins, Temitope Wilson Ademolue, Birte Blankenhaus, Zélia Gouveia, Pedro Faísca, Damian Trujillo, Sílvia Cardoso, Sofia Rebelo, Laura del Barrio, Abolfazl Zarjou, Subhashini Bolisetty, Anupam Agarwal, Miguel P. Soares
Dátum:	2019
ISSN:	0027-8424 1091-6490
Megjegyzések:	Malaria, the disease caused by Plasmodium spp. infection, remains a major global cause of morbidity and mortality. Host protection from malaria relies on immune-driven resistance mechanisms that kill Plasmodium However, these mechanisms are not sufficient per se to avoid the development of severe forms of disease. This is accomplished instead via the establishment of disease tolerance to malaria, a defense strategy that does not target Plasmodium directly. Here we demonstrate that the establishment of disease tolerance to malaria relies on a tissue damage-control mechanism that operates specifically in renal proximal tubule epithelial cells (RPTEC). This protective response relies on the induction of heme oxygenase-1 (HMOX1; HO-1) and ferritin H chain (FTH) via a mechanism that involves the transcription-factor nuclear-factor E2-related factor-2 (NRF2). As it accumulates in plasma and urine during the blood stage of Plasmodium infection, labile heme is detoxified in RPTEC by HO-1 and FTH, preventing the development of acute kidney injury, a clinical hallmark of severe malaria.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk disease tolerance heme infection kidney malaria
Megjelenés:	Proceedings of the National Academy of Sciences of the United States of America. - 116 : 12 (2019), p. 5681-5686. -
További szerzők:	Carlos, Ana Rita Sundaram, Balamurugan Jeney Viktória (1971-) (vegyész, kémia tanár) Ribeiro, Ana Gozzelino, Raffaella Bank, Claudia Gjini, Erida Braza, Faouzi Martins, Rui Ademolue, Temitope Wilson Blankenhaus, Birte Gouveia, Zélia Faísca, Pedro Trujillo, Damian Cardoso, Sílvia Rebelo, Sofia del Barrio, Laura Zarjou, Abolfazl (1979-) (kutató orvos) Bolisetty, Subhashini Agarwal, Anupam Soares, Miguel P.
Pályázati támogatás:	OTKA-116024 OTKA
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
Borító:
Saját polcon: