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001-es BibID:	BIBFORM049447
Első szerző:	Rönsberg, David
Cím:	Pro-Apoptotic and Immunostimulatory Tetrahydroxanthone Dimers from the Endophytic Fungus Phomopsis longicolla / David Ronsberg, Abdessamad Debbab, Attila Mandi, Vera Vasylyeva, Philip Bohler, Bjorn Stork, Laura Engelke, Alexandra Hamacher, Richard Sawadogo, Marc Diederich, Victor Wray, WenHan Lin, Matthias U. Kassack, Christoph Janiak, Stefanie Scheu, Sebastian Wesselborg, Tibor Kurtan, Amal H. Aly, Peter Proksch
Dátum:	2013
ISSN:	0022-3263
Megjegyzések:	Four tetrahydroxanthone dimers (1-4) and four biogenetically related monomers (5-8), including the new derivatives 4-6, were isolated from the endophyte Phomopsis longicolla. The absolute configurations of 2-4 were established for the first time by TDDFT electronic circular dichroism calculations, and that of phomoxanthone A (1) was revised by X-ray crystallography. Phomoxanthone A (1) showed the strongest pro-apoptotic activity when tested against a panel of human cancer cell lines, including cisplatin-resistant cells, whereas it was up to 100-fold less active against healthy blood cells. It was also the most potent activator of murine T lymphocytes, NK cells, and macrophages, suggesting an activation of the immune system in parallel to its pro-apoptotic activity. This dual effect in combating cancer cells could help in fighting resistance during chemotherapy. Preliminary structure-activity studies of isolated compounds and derivatives obtained by semisynthesis (9a-11) hinted at the location of the biaryl axis and the presence of acetyl groups as important structural elements for the biological activity of the studied tetrahydroxanthones.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Organic Chemistry. - 78 : 24 (2013), p. 12409-12425. -
További szerzők:	Debbab, Abdessamad Mándi Attila (1981-) (vegyész, német szakfordító) Vasylyeva, Vera Böhler, Philip Stork, Björn Engelke, Laura Hamacher, Alexandra Sawadogo, Richard Diederich, Marc Wray, Victor Lin, Wen Han Kassack, Matthias Janiak, Christoph Scheu, Stefanie Wesselborg, Sebastian Kurtán Tibor (1973-) (vegyész, angol szakfordító) Aly, Amal H. Proksch, Peter
Pályázati támogatás:	K105871 OTKA TÁMOP-4.2.4.A/2-11-1-2012-0001 TÁMOP NIIFI 10038 Egyéb
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