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001-es BibID:	BIBFORM110785
035-os BibID:	(Scopus)85156242117 (WoS)000977626300001
Első szerző:	Trencsényi György (biológus, biokémikus, molekuláris biológus)
Cím:	Scandium-44 : Diagnostic Feasibility in Tumor-Related Angiogenesis / Trencsényi György, Képes Zita
Dátum:	2023
ISSN:	1422-0067
Megjegyzések:	Angiogenesis-related cell-surface molecules, including integrins, aminopeptidase N, vascular endothelial growth factor, and gastrin-releasing peptide receptor (GRPR), play a crucial role in tumour formation. Radiolabelled imaging probes targeting angiogenic biomarkers serve as valuable vectors in tumour identification. Nowadays, there is a growing interest in novel radionuclides other than gallium-68 (68Ga) or copper-64 (64Cu) to establish selective radiotracers for the imaging of tumour-associated neo-angiogenesis. Given its ideal decay characteristics (E?+average: 632 KeV) and a half-life (T1/2 = 3.97 h) that is well matched to the pharmacokinetic profile of small molecules targeting angiogenesis, scandium-44 (44Sc) has gained meaningful attention as a promising radiometal for positron emission tomography (PET) imaging. More recently, intensive research has been centered around the investigation of 44Sc-labelled angiogenesis-directed radiopharmaceuticals. Previous studies dealt with the evaluation of 44Sc-appended avb3 integrin?affine Arg-Gly-Asp (RGD) tripeptides, GRPR-selective aminobenzoyl?bombesin analogue (AMBA), and hypoxia-associated nitroimidazole derivatives in the identification of various cancers using experimental tumour models. Given the tumour-related hypoxia- and angiogenesis-targeting capability of these PET probes, 44Sc seems to be a strong competitor of the currently used positron emitters in radiotracer development. In this review, we summarize the preliminary preclinical achievements with 44Sc-labelled angiogenesis-specific molecular probes.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk aminobenzoyl-bombesin analogue (AMBA aminopeptidase N (APN/CD13) angiogenesis carcinogenesis gastrin-releasing peptide receptor (GRPR) integrin nitroimidazole positron emission tomography (PET) Arg-Gly-Asp (RGD) scandium-44 (44Sc)
Megjelenés:	International Journal Of Molecular Sciences. - 24 : 8 (2023), p. 1-23. -
További szerzők:	Képes Zita (1991-) (orvos)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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