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001-es BibID:BIBFORM113281
035-os BibID:(Scopus)85163179051 (WoS)001006368000001
Első szerző:Al-Omari, Mothana K.
Cím:Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments : challenge and hope / Mothana K. Al-Omari, Mai Elaarag, Raed M. Al-Zoubi, Ahmad R. Al-Qudimat, Ayman A. Zarour, Enas A. Al-Hurani, Zainab E. Fares, Leena M. Alkharraz, Mohanad Shkoor, Abdulilah D. Bani-Yaseen, Omar M. Aboumarzouk, Aksam Yassin, Abdulla A. Al-Ansari
Dátum:2023
ISSN:1475-6366
Megjegyzések:Boronic acids/esters have recently emerged in the field of medicinal and pharmaceutical research due to their exceptional oxophilicity, low toxicity, and unique structure. They are known as potent enzyme inhibitors, cancer therapy capture agents, and can mimic certain types of antibodies to fight infections. They have been designed and developed into drugs, and this approach has emerged in the last 20?years. Five boronic acid drugs have been approved by the FDA and Health Canada, two of which are used to treat cancer, specifically multiple myeloma. The purpose of this review is to investigate boronic acid/ester derivatives as potential pharmaceutical agents as well as the mechanism of action. It will concentrate on six types of cancer: multiple myeloma, prostate cancer, breast cancer, lung cancer, cervical cancer, and colon cancer. Some newly developed boron-containing compounds have already demonstrated highly promising activities, but further investigation is required before final conclusions can be drawn.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal Of Enzyme Inhibition And Medicinal Chemistry. - 38 : 1 (2023), p. 1-16. -
További szerzők:Elaarag, Mai Al-Zoubi, Raed M. Al-Qudimat, Ahmad R. Zarour, Ayman A. Al-Hurani, Enas A. Fares, Zainab E. Alkharraz, Leena M. Shkoor, Mohanad Bani-Yaseen, Abdulilah D. Aboumarzouk, Omar M. Yassin, Aksam Al-Ansari, Abdulla A.
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