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001-es BibID:	BIBFORM113500
035-os BibID:	(Scopus)85160448951 (WoS)000995924400001
Első szerző:	Li, Yan-He
Cím:	Isolation and characterization of three pairs of verrucosidin epimers from the marine sediment?derived fungus Penicillium cyclopium and confguration revision of penicyrone A and related analogues / Yan?He Li, Attila Mándi, Hong?Lei Li, Xiao?Ming Li, Xin Li, Ling?Hong Meng, Sui?Qun Yang, Xiao?Shan Shi, Tibor Kurtán, Bin?Gui Wang
Dátum:	2023
ISSN:	2662-1746
Megjegyzések:	Verrucosidins, a methylated alpha-pyrone class of polyketides rarely reported upon, have been implicated in one or more neurological diseases. Despite the significance of verrucosidins as neurotoxins, the absolute configurations of most of the derivatives have not been accurately characterized yet. In this study, three pairs of C-9 epimeric verrucosidin derivatives, including the known compounds penicyrones A and B (1a/1b) and 9-O-methylpenicyrones A and B (2a/2b), the new compounds 9-O-ethylpenicyrones A and B (3a/3b), together with the related known derivative verrucosidin (4), were isolated and identified from the culture extract of Penicillium cyclopium SD-413, which was obtained from the marine sediment collected from the East China sea. Their structures were established based on an in-depth analysis of nuclear magnetic resonances (NMR) and mass spectroscopic data. Determination of the absolute configurations of these compounds was accomplished by Mosher's method and time-dependent density functional theory (TDDFT) calculations of electronic circular dichroism (ECD) and optical rotation (OR). The configurational assignment of penicyrone A demonstrated that the previously reported C-6 absolute configuration of verrucosidin derivatives needs to be revised from (6S) to (6R). The 9R/9S epimers of compounds 1-3 were found to exhibit growth inhibition against some pathogenic bacteria, indicating that they have potential as lead compounds for the creation of antimicrobial agents.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Marine Life Science & Technology. - 5 : 2 (2023), p. 223-231. -
További szerzők:	Mándi Attila (1981-) (vegyész, német szakfordító) Li, Hong-Lei Li, Xiao-Ming Li, Xin Meng, Ling-Hong Yang, Sui-Qun Shi, Xiao-Shan Kurtán Tibor (1973-) (vegyész, angol szakfordító) Wang, Bin-Gui
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