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001-es BibID:	BIBFORM117772
035-os BibID:	(Scopus)85180713903 (WoS)001133874100001
Első szerző:	Mukli Péter
Cím:	Impaired Neurovascular Coupling and Increased Functional Connectivity in the Frontal Cortex Predict Age-Related Cognitive Dysfunction / Mukli Peter, Pinto Camila B., Owens Cameron D., Csipo Tamas, Lipecz Agnes, Szarvas Zsofia, Peterfi Anna, Langley Ana Clara da Costa Pinaffi, Hoffmeister Jordan, Racz Frigyes Samuel, Perry Jonathan W., Tarantini Stefano, Nyúl-Tóth Ádám, Sorond Farzaneh A., Yang Yuan, James Judith A., Kirkpatrick Angelia C., Prodan Calin I., Toth Peter, Galindo Juliette, Gardner Andrew W., Sonntag William E., Csiszar Anna, Ungvari Zoltan, Yabluchanskiy Andriy
Dátum:	2024
ISSN:	2198-3844
Megjegyzések:	Impaired cerebrovascular function contributes to the genesis of age-related cognitive decline. In this study, the hypothesis is tested that impairments in neurovascular coupling (NVC) responses and brain network function predict cognitive dysfunction in older adults. Cerebromicrovascular and working memory function of healthy young (n = 21, 33.2?7.0 years) and aged (n = 30, 75.9-6.9 years) participants are assessed. To determine NVC responses and functional connectivity (FC) during a working memory (n-back) paradigm, oxy- and deoxyhemoglobin concentration changes from the frontal cortex using functional near-infrared spectroscopy are recorded. NVC responses are significantly impaired during the 2-back task in aged participants, while the frontal networks are characterized by higher local and global connection strength, and dynamic FC (p < 0.05). Both impaired NVC and increased FC correlate with age-related decline in accuracy during the 2-back task. These findings suggest that task-related brain states in older adults require stronger functional connections to compensate for the attenuated NVC responses associated with working memory load.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk aging cognitive decline functional connectivity functional near-infrared spectroscopy neurovascular coupling
Megjelenés:	Advanced Science. - 11 : 10 (2024), p. 1-18. -
További szerzők:	Pinto, Camila B. Owens, Cameron D. Csípő Tamás (1990-) Lipécz Ágnes Szarvas Zsófia Péterfi Anna Langley, Ana Clara da Costa Pinaffi Hoffmeister, Jordan Rácz Frigyes Sámuel Perry, Jonathan W. Tarantini, Stefano Nyúl-Tóth Ádám Sorond, Farzaneh A. Yang, Yuan James, Judith A. Kirkpatrick, Angelia C. Prodan, Calin I. Tóth Péter Galindo, Juliette Gardner, Andrew W. Sonntag, William E. Csiszár Anna Ungvári Zoltán Yabluchanskiy, Andriy
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