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001-es BibID:	BIBFORM130701
035-os BibID:	(WoS)001432493900001 (Scopus)85219531336
Első szerző:	Homonnay Zalán G.
Cím:	Genomic Mosaicism in Fowl Adenovirus 3 Strains / Zalán Homonnay, Szilvia Jakab, Szilvia Marton, Marianna Domán, Krisztina Bali, Eszter Kaszab, Gábor Kemenesi, Tamás Mató, István Kiss, Vilmos Palya, Krisztián Bányai
Dátum:	2025
ISSN:	2076-2615
Megjegyzések:	Fowl adenovirus D is the main cause of inclusion body hepatitis in chickens. Whole genome sequencing was carried out to enrich the genomic sequence database using field isolates of FAdV-D. Out of 44 newly determined genomes, 43 were classified into FAdV-2/-11 and 2 into FAdV-3; no FAdV-9 was identified. Whole-genome based phylogeny showed that FAdV-3 was more distantly related to FAdV 9 and FAdV-2/-11 than FAdV-9 and FAdV-2/-11 to each other. Whole-genome sequence homology analysis revealed that the full-length FAdV-3 genome harbored a ~12 kbp fragment of the genome that shared moderate sequence homology with representative strains of other FAdV-D serotypes but high relatedness with only the FAdV-3 strain whose full-genome is available in GenBank. A closer look onto the fiber and the penton genes of our FAdV-3 isolate identified putative recombination events; both the fiber and the penton coding genes shared fragments originating from FAdV-9. Of interest, ORF19 displayed a close relationship with the homologous genomic region of some FAdV-E strains (amino acid sequence homology, up to 82%). Thus, although FAdV-3 is classified into FAdV-D, the genomic structure of FAdV-3 appears to result from multiple heterotypic and heterologous recombination events. This study highlights the unique origin of FAdV-3.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Animals. - 15 : 4 (2025), p. 1-10. -
További szerzők:	Jakab Szilvia Marton Szilvia Domán Marianna (1987-) (biológus) Bali Krisztina Kaszab Eszter (1989-) (biológus) Kemenesi Gábor Mató Tamás Kiss István (Budapest) Palya Vilmos Bányai Krisztián (virológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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