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1.
001-es BibID:
BIBFORM003761
Első szerző:
Nyolczas Noémi
Cím:
Design and rationale for the Myocardial Stem Cell Administration After Acute Myocardial Infarction (MYSTAR) Study : a multicenter, prospective, randomized, single-blind trial comparing early and late intracoronary or combined (percutaneous intramyocardial and intracoronary) administration of nonselected autologous bone marrow cells to patients after acute myocardial infarction / Nyolczas, N., Gyongyosi, M., Beran, G., Dettke, M., Graf, S., Sochor, H., Christ, G., Edes, I., Balogh, L., Krause, K. T., Jaquet, K., Kuck, K. H., Benedek, I., Hintea, T., Kiss, R., Preda, I., Kotevski, V., Pejkov, H., Dudek, D., Heba, G., Sylven, C., Charwat, S., Jacob, R., Maurer, G., Lang, I., Glogar, D.
Dátum:
2007
Megjegyzések:
Previous data suggest that bone marrow-derived stem cells (BM-SCs) decrease the infarct size and beneficially affect the postinfarction remodeling. METHODS: The Myocardial Stem Cell Administration After Acute Myocardial Infarction Study is a multicenter, prospective, randomized, single-blind clinical trial designed to compare the early and late intracoronary or combined (percutaneous intramyocardial and intracoronary) administration of BM-SCs to patients after acute myocardial infarction (AMI) with reopened infarct-related artery. The primary end points are the changes in resting myocardial perfusion defect size and left ventricular ejection fraction (gated single photon emission computed tomography [SPECT] scintigraphy) 3 months after BM-SCs therapy. The secondary end points relate to evaluation of (1) the safety and feasibility of the application modes, (2) the changes in left ventricular wall motion score index (transthoracic echocardiography), (3) myocardial voltage and segmental wall motion (NOGA mapping), (4) left ventricular end-diastolic and end-systolic volumes (contrast ventriculography), and (5) the clinical symptoms (Canadian Cardiovascular Society [CCS] anina score and New York Heart Association [NYHA] functional class) at follow-up. Three hundred sixty patients are randomly assigned into 1 of 4 groups: group A, early treatment (21-42 days after AMI) with intracoronary injection; group B, early treatment with combined application; group C, late treatment (3 months after AMI) with intracoronary delivery; and group D, late treatment with combined administration of BM-SCs. Besides the BM-SCs therapy, the standardized treatment of AMI is applied in all patients. CONCLUSIONS: The Myocardial Stem Cell Administration After Acute Myocardial Infarction Trial is the first randomized trial to investigate the effects of the combined (intramyocardial and intracoronary) and the intracoronary mode of delivery of BM-SCs therapy in the early and late periods after AMI.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
Bone Marrow Cells
Bone Marrow Transplantation
Coronary Vessels
Echocardiography
Humans
methods
Multicenter Studies as Topic
Myocardial Infarction
Myocardium
Perfusion
Prospective Studies
Research Design
Single-Blind Method
surgery
therapy
Time Factors
Megjelenés:
American Heart Journal. - 153 : 2 (2007), p. 212-217. -
További szerzők:
Gyöngyösi Mariann
Beran, Gilbert
Dettke, Markus
Graf, Senta
Sochor, Heinz
Christ, Günther
Édes István (1952-) (kardiológus)
Balogh László (1976-) (kardiológus)
Krause, Korff T.
Jaquet, Kai
Kuck, Karl Heinz
Benedek Imre
Hintea, Theodora
Kiss Róbert
Préda István
Kotevski Vladimir
Pejkov, Hristo
Dudek, Darius
Heba, Grzegorz
Sylven, Christer
Charwat, Silvia
Jacob, Ronaldo
Maurer, Gerald
Lang, Irene
Glogar, Dietmar
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