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001-es BibID:	BIBFORM010173
Első szerző:	Nagy Miklós (vegyész)
Cím:	Poly(vinyl alcohol)-based amphiphilic copolymer aggregates as drug carrying nanoparticles / Miklós Nagy, László Szőllősi, Sándor Kéki, Rudolf Faust, Miklós Zsuga
Dátum:	2009
Megjegyzések:	A series of amphiphilic polyisobutylene-block-poly(vinyl alcohol) (PIB-b-PVA) copolymers of constant PIB and varying PVA block length was synthesized by living carbocationic polymerization and their solvent state behavior was studied. The synthesis involved a two-step process, namely the preparation of polyisobutylene-b-poly(tert butyl vinyl ether) and its hydrolysis with hydrogen bromide. The copolymers formed were characterized by gel permeation chromatography, 1H-NMR, and MALDI-TOF MS methods. The self-assembly behavior of the copolymers was investigated in aqueous media by direct dissolution and dialysis using light scattering methods. The critical micelle concentration, micelle size, aggregation number, and micelle shape were determined. The ability of the aggregates as drug carrying nanodevices was also investigated by doping them with indomethacin. UV-Vis measurements showed that the solubility of indomethacine increased significantly, even with a tenfold increase being found in one case. Our findings suggest that the solubility is largely dependent upon the segment ratios of the blocks.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Polyisobutylene poly(vinyl alcohol) block copolymer self assembly indomethacin
Megjelenés:	Journal of Macromolecular Science, Part A - Pure and Applied Chemistry. - 46 : 4 (2009), p. 331-338. -
További szerzők:	Szőllősi László Kéki Sándor (1964-) (polimer kémikus) Faust, Rudolf Zsuga Miklós (1944-) (polimer kémikus)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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