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001-es BibID:BIBFORM013278
Első szerző:Reglődi Dóra (Idegtudományok)
Cím:Alterations of pituitary adenylate cyclase-activating polypeptide-like immunoreactivity in the human plasma during pregnancy and after birth / D. Reglodi, J. Gyarmati, T. Ertl, R. Borzsei, J. Bodis, A. Tamas, P. Kiss, K. Csanaky, E. Banki, C. Bay, J. Nemeth, Z. Helyes
Megjegyzések:Pituitary adenylate cyclase-activating polypeptide (PACAP)was discovered from the hypothalamus and it belongs tothe vasoactive intestinal peptide (VIP)/secretin/glucagonspeptide family (1). It occurs in two biologically active forms,with 38 and 27 amino-acid residues. The first studies reportedon its adenylate cyclase activation in pituitary cellsand described its distribution in hypothalamic nuclei influencingpituitary hormone secretion (1). Although the last 20years since its discovery have revealed numerous distincteffects in the nervous system and various peripheral organs,its endocrine functions still represent a major focusin PACAP research. PACAP influences, among others, therelease of GnRH and FSH in different species (2, 3) andthe secretion of PRL (4-6). PACAP also influences sexualbehavior, ovarian follicular maturation, and fertility (3, 7,8), uteroplacental circulation (9), and trophoblast survival(10). Furthermore, PACAP is a very important trophic factor,especially during the development of the nervous system(1, 11). Radioimmunoassay (RIA) analysis revealed thatPACAP38 concentration is higher in the hypophyseal portalblood than in the peripheral circulation in the rat (12). Inspite of the vast literature on PACAP, there are only fewhuman studies. The presence of PACAP has been shownin human blood and some other tissues (1, 13). The half-lifeof PACAP in the circulation is relatively short, only a fewminutes, due to rapid enzymatic degradation by dipeptidyl-peptidase IV (14). We have recently shown the presenceof PACAP38 in human milk by mass spectrometry,and we have also found that PACAP38-like immunoreactivity(PACAP38-LI) is 5-20 times higher in the milk than inthe plasma (15). In humans, PACAP has also been shownto influence PRL, vasopressin, and oxytocin secretion (5,16). Immunohistochemical studies have revealed the presenceof PACAP and its receptors in the female reproductivesystem, including the placenta, uterus, and mammarygland (9, 17). Recent studies have suggested the involvementof PACAP in the pathophysiological processes ofstress urinary incontinence and the prolapse of pelvic organsin female patients (18).Regarding the role of PACAP in reproductive functionsand the urging need to obtain further human data, theaim of the present study was to investigate whether theconcentration of PACAP is altered during normal pregnancy,delivery, and after childbirth. We also measuredthe levels of endogenous PACAP with RIA in the peripheralblood and of newborn babies, as well as in the bloodobtained from the umbilical arteries and veins.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
umbilical vessels
Megjelenés:Journal of Endocrinological Investigation. - 33 : 7 (2010), p. 443-445. -
További szerzők:Gyarmati János (1926-1983) (radiológus) Ertl Tibor Börzsei Rita Bodis József (Pécs) Tamás A. (Pécs) Kiss Péter (Pécs) Csanaky Katalin Bánki Eszter Bay Csaba Németh József (1954-) (vegyész, analitikus) Helyes Zsuzsanna
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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