Találati lista | Tudóstér

001-es BibID:	BIBFORM030274
035-os BibID:	(Scopus)0345434847 (WoS)000079560700007
Első szerző:	Bányász Tamás (élettanász)
Cím:	EGIS-7229, the new combined class III antiarrhythmic agent : lack of EAD inducing effect / Tamás Bányász, János Magyar, András Varró, Anikó Kovács, Ildikó Gyönös, Gábor Szénási, Péter P. Nánási
Dátum:	1999
ISSN:	0306-3623
Megjegyzések:	EGIS-7229 is a novel antiarrhythmic candidate having multiple mechanisms of action with class III predominance. In this study, the effects of EGIS-7229 and sotalol on action potential duration (APD) and incidence of early afterdepolarizations (EADs) were studied and compared in rabbit papillary muscle by using conventional microelectrode techniques. In control bathing solution, both drugs increased APD in a concentration-dependent manner; however, the prolongation of APD was greater with sotalol than with EGIS-7229 when the same drug concentrations were compared. EAD developed in 3 of the 11 preparations (27%) bathed with a solution containing 3.6 mmol/l CsCl + 2 mmol/l KCl within the first 120 min of superfusion. The addition of 100 mu mol/l sotalol to this superfusate increased the incidence of EAD to 83% (10 from 12), whereas the addition of the same concentration of EGIS-7229 prevented the development of EAD in all of the 9 preparations studied. These differences in incidence of EAD are likely attributable to differences in drug-induced increases of APD-50 in the presence of CsCl. Prolongation of APD-90 showed less correlation with incidence of EAD than changes in APD-50. On the basis of these in vitro results, high concentrations of EGIS-7229 cannot be expected to be torsadogenic in vivo-in contrast with sotalol-presumably owing to the combined class III + IV activity of the compound. (C) 1999 Elsevier Science Inc. All rights reserved.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	General Pharmacology. - 32 : 3 (1999), p. 329-333. -
További szerzők:	Magyar János (1961-) (élettanász) Varró András (1954-) (farmakológus, klinikai farmakológus) Kovács Anikó Gyönös Ildikó Szénási Gábor Nánási Péter Pál (1956-) (élettanász)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: