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001-es BibID:	BIBFORM030337
035-os BibID:	(Scopus)0029739694 (WoS)A1996UW72900009 (PMID) 8766913
Első szerző:	Szigligeti Péter
Cím:	Action potential duration and force-frequency relationship in isolated rabbit, guinea pig and rat cardiac muscle / P. Szigligeti, Cs. Pankucsi, T. Banyasz, A. Varro, P. P. Nanasi
Dátum:	1996
ISSN:	0174-1578
Megjegyzések:	The effect of action potential duration and elevated cytosolic sodium concentration on the force-frequency relationship in isolated rabbit, guinea pig and rat papillary muscle preparations was studied. Shortening of action potential duration in guinea pig and rabbit from 150-200 ms to values characteristic of rat (20-40 ms), using the K-(ATP) channel activator levkromakalim (15 mu mol . l(-1)), markedly reduced the force of contraction and converted the positive force-frequency relationship into negative one at longer pacing cycle lengths. This conversion was greatly enhanced in the presence of acetylstrophanthidin (0.2-1 mu mol . l(-1)), an inhibitor of the Na-K pump. Acetylstrophanthidin (1 mu mol . l(-1)) alone, however, had no effect on the force-frequency relationship. Prolongation of action potential duration in rat with inhibitors of cardiac K channels (4-aminopyridine [10 mmol . l(-1)] plus tetraethylammonium [2 mmol . l(-1)] increased the force of contraction and abolished the negative force-frequency relationship observed in rat at longer pacing-cycle lengths. It is concluded that both action potential duration and cytosolic sodium concentration are major determinants of the force-frequency relationship in mammalian myocardium.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Journal of Comparative Physiology B-Biochemical Systemic and Environmental Physiology. - 166 : 2 (1996), p. 150-155. -
További szerzők:	Pankucsi Csaba (farmakológus) Bányász Tamás (1960-) (élettanász) Varró András (1954-) (farmakológus, klinikai farmakológus) Nánási Péter Pál (1956-) (élettanász)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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