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001-es BibID:	BIBFORM056646
Első szerző:	Zhang, Mengen
Cím:	Impact of Dendrimer Surface Functional Groups on the Release of Doxorubicin from Dendrimer Carriers / Mengen Zhang, Rui Guo, Monika Kéri, Istvan Bányai, Yun Zheng, Mian Cao, Xueyan Cao, Xiangyang Shi
Dátum:	2014
ISSN:	1520-6106
Megjegyzések:	Generation 5 (G5) poly(amidoamine) dendrimers with acetyl (G5.NHAc), glycidol hydroxyl (G5.NGlyOH), and succinamic acid (G5.SAH) terminal groups were used to physically encapsulate an anticancer drug doxorubicin (DOX). Both UV?vis spectroscopy and multiple NMR techniques including one-dimensional NMR and two-dimensional NMR were applied to investigate the interactions between different dendrimers and DOX. The influence of the surface functional groups of G5 dendrimers on the DOX encapsulation, release kinetics, and cancer cell inhibition effect was investigated. We show that all three types of dendrimers are able to effectively encapsulate DOX and display therapeutic inhibition effect to cancer cells, which is solely associated with the loaded DOX. The relatively stronger interactions of G5.NHAc or G5.NGlyOH dendrimers with DOX than that of G5.SAH dendrimers with DOX demonstrated by NMR techniques correlate well with the slow release rate of DOX from G5.NHAc/DOX or G5.NGlyOH/DOX complexes. In contrast, the demonstrated weak interaction between G5.SAH and DOX causes a fast release of DOX, suggesting that the G5.SAH/DOX complex may not be a proper option for further in vivo research. Our findings suggest that the dendrimer surface functional groups are crucial for further design of multifunctional dendrimer-based drug delivery systems for various biomedical applications.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban PAMAM dendrimer doxorubicin
Megjelenés:	Journal Of Physical Chemistry B. - 118 : 6 (2014), p. 1696-1706. -
További szerzők:	Guo, Rui Kéri Mónika (1984-) (környezetkutató vegyész) Bányai István (1953-) (vegyész) Zheng, Yun Cao, Mian Cao, Xueyan Shi, Xiangyang
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