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001-es BibID:BIBFORM058269
Első szerző:Antal Zsófia (orvos)
Cím:Neurons in the lateral part of the lumbar spinal cord show distinct novel axon trajectories and are excited by short propriospinal ascending inputs / Zs. Antal, L. L. Luz, B. V. Safronov, M. Antal, P. Szűcs
ISSN:1863-2653 1863-2661
Megjegyzések:The role of spinal dorsal horn propriospinal connections in nociceptive processing isnot yet established. Recently described, rostrocaudally oriented axon collaterals oflamina I projection and local-circuit neurons (PNs and LCNs) running in thedorsolateral funiculus (DLF) may serve as the anatomical substrate for intersegmentalprocessing. Putative targets of these axons include lateral dendrites of superficialdorsal horn neurons, including PNs, and also neurons in the lateral spinal nucleus(LSN) that are thought to be important integrator units receiving, among others,visceral sensory information. Here we used an intact spinal cord preparation to studyintersegmental connections within the lateral part of the superficial dorsal horn. Wedetected brief monosynaptic and prolonged polysynaptic excitation of lamina I and LSNneurons when stimulating individual dorsal horn neurons located caudally, even inneighbouring spinal cord segments. These connections, however, were infrequent. Wealso revealed that some projection neurons outside the dorsal grey matter and in theLSN have distinct, previously undescribed course of their projection axon. Our findingsindicate that axon collaterals of lamina I PNs and LCNs in the DLF rarely formfunctional connections with other lamina I and LSN neurons and that the majority oftheir targets are on other elements of the dorsal horn. The unique axon trajectories ofneurons in the dorsolateral aspect of the spinal cord, including the LSN do not fit ourpresent understanding of midline axon guidance and suggest that their function anddevelopment differ from the neurons inside lamina I. These findings emphasize theimportance of understanding the connectivity matrix of the superficial dorsal horn inorder to decipher spinal sensory information processing.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
lateral spinal nucleus
propriospinal connection, midline crossing
ipsilateral projection, bilateral projection
3-D reconstruction
Megjelenés:Brain Structure & Function 221 : 4 (2016), p. 2343-2360. -
További szerzők:Luz, Liliana L. Safronov, Boris V. Antal Miklós (1951-) (orvos, anatómus) Szűcs Péter (1974-) (kutatóorvos)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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