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001-es BibID:BIBFORM064403
Első szerző:Deák Eszter (klinikai laboratóriumi kutató)
Cím:Alterations in ophthalmological parameters and cytokine levels in tears of patients with glaucoma / Eszter Deák, Éva Csősz, Adrienne Csutak
Megjegyzések:Glaucoma is a progressive, chronic neurodegenerative disease with a multifactorial pathophysiology that affects the optic nerve and may cause loss of function up to the blindness. This disease has several types, but generally categorized by the anterior chamber (iridocorneal) angle. The openBangle glaucoma (OAG) and the angleBclosure glaucoma (ACG) can be divided into primary and secondary forms and also can be categorized as acute or chronic. Actually, the elevated intraocular pressure (IOP) is the only risk factor that can be influenced with therapy such as medications or glaucoma surgery. In routine clinical use, different classification systems are used to evaluate and quantify the anterior chamber angle. One of them is based on Scheimpflug imaging, like the Oculus Pentacam. This imaging technology provides quantitative data regarding of anterior chamber characteristics and may serve as a useful adjunct for glaucoma diagnosis and monitoring reducing chances of this error bias. One of the advantages of the Pentacam over other noncontact instruments such as optical pachymetry is that the anterior chamber volume (ACV), anterior chamber depth (ACD) and anterior chamber angle (ACA), as well as the corneal thickness and corneal topography can be obtained at the same time. The corneal tear film contains numerous proteins the qualitative and quantitative pattern of which can be pathognomonic in various ophthalmic conditions. The tear can be collected via nonBinvasive way, so it is an appropriate sample type for biomarker studies. Results from previous research showed that there is a link between the inflammatory cytokine level and the different type of glaucoma eye structural changing. Our aim was to identify specific correlations between these parametric imaging changes and examine how to correlate with the proteome changes with cytokine profiles in glaucoma. The cytokine profile in tear samples of 10 OAG, 10 ACG patients and 10 age and sexBmatched healthy volunteers was analyzed by multiplex cytokine assay.
ISBN:978 961 93879 0 0
Tárgyszavak:Orvostudományok Klinikai orvostudományok előadáskivonat
Megjelenés:Molecules of Life FEBS3+ Meeting / Ed. Janko Kos, Natasa Poklar Ulrih. - p. 247
További szerzők:Csősz Éva (1977-) (biokémikus, molekuláris biológus) Csutak Adrienne (1971-) (szemész)
Pályázati támogatás:TÁMOP-4.2.2.A-11/1/KONV-2012-0045
Proteomika, Szemészet Kutatócsoport
Proteomika, Szemészet Kutatócsoport
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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