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001-es BibID:	BIBFORM067615
035-os BibID:	(Scopus)85011966212 (WoS)000392126200006
Első szerző:	Máthé Csaba (biológus)
Cím:	Cellular effects of cylindrospermopsin (Cyanobacterial Alkaloid Toxin) and its potential medical consequences / Máthé C., M-Hamvas M., Garda T., Beyer D., Vasas G.
Dátum:	2017
ISSN:	0929-8673 1875-533X
Megjegyzések:	Cylindrospermopsin (CYN) is a tricyclic guanidino derivative, an alkaloid toxin produced by several cyanobacterial genera. It alters cellular functioning in eukaryotes, including animal and plant organisms. Over the past decades, more and more evidence shows its potential hazardous effects on animal and human health. In this review, we give a critical survey and interpretation of data currently available on its biochemical and consequently, cellular effects. CYN is considered to be a cytotoxin. Several reports suggest that it is a potent inhibitor of eukaryotic protein synthesis, though the exact mechanisms are far from not completely understood. Here we show that the biochemical changes induced by CYN suggest are complex, and possibly involving multiple modes of action. Glutathione metabolism and pyrimidine nucleotide synthesis is affected besides the proposed protein synthesis inhibition. Biochemical alterations lead to the following cellular/subcellular alterations both in animals and plants: (i) changes in cell division rates due to perturbations in chromatin and cytoskeleton; (ii) perturbations of structure and functioning of endomembranes including endoplasmic reticulum; (iii) general metabolic alterations leading to genotoxicity and programmed cell death/apoptosis. The underlying mechanisms and possible health consequences are discussed.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Cylindrospermopsin cyanobacteria, protein synthesis cell cycle endomembranes cytoskeleton programmed cell death
Megjelenés:	Current Medicinal Chemistry. - 24 : 1 (2017), p. 91-109. -
További szerzők:	Mikóné Hamvas Márta (1963-) (biológus) Garda Tamás (1990-) (biológus) Beyer Dániel (1982-) (molekuláris biológus) Vasas Gábor (1975-) (biológus-vegyész)
Pályázati támogatás:	K120638 OTKA K119647 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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