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001-es BibID:BIBFORM072581
035-os BibID:(cikkazonosító)1017 (scopus)85044643567 (wos)000434978700096
Első szerző:Czompa Attila (gyógyszerész)
Cím:Aged (Black) versus Raw Garlic against Ischemia/Reperfusion-Induced Cardiac Complications / Attila Czompa, Kitti Szoke, Jozsef Prokisch, Alexandra Gyongyosi, Istvan Bak, Gyorgy Balla, Arpad Tosaki, Istvan Lekli
Dátum:2018
ISSN:1661-6596 1422-0067
Megjegyzések:Background: Recent evidence of studies suggests that aged black garlic also has health beneficial effect. The major aim of the present study is to compare the effect of raw and aged black garlic on postischemic cardiac recovery. Methods: Male Sprague Dawley rats were randomly divided into three groups. Animals of the first group were fed with raw garlic, animals of the second group received aged black garlic, while the third group served as vehicle treated control. At the end of the treatment, isolated hearts were undertaken to ischemia/reperfusion. Heart function and infarct size were measured and the level of HO-1 and iNOS were studied. Results: We have found superior postichemic cardiac function and reduced infarct size in both garlic treated groups compared to the drug-free control group, indicating cardioprotective effects. However, no significant differences between the garlic treated groups were observed. Our Western blot analysis revealed that raw garlic enhanced the level of HO-1 before ischemia, while in ischemic samples we found elevated HO-1 expression in both garlic treated groups. The level of iNOS was the same before ischemia in all groups, however, a markedly reduced iNOS level in ischemic/reperfused hearts originated from control and raw garlic treated animals was observed. In samples from aged black garlic treated animals, the level of iNOS was not significantly reduced after ischemia/reperfusion.Conclusion: Taken together our results indicate that not only raw but also aged black garlic also possesses cardioprotective effect.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
garlic
ischemia
hemeoxygenase
reperfusion
heart
Megjelenés:International Journal of Molecular Sciences. - 19 : 4 (2018), p. 1-13. -
További szerzők:Szőke Kitti Prokisch József (1966-) (vegyész) Gyöngyösi Alexandra (1990-) (táplálkozástudományi szakember) Bak István (1975-) (vegyész, analitikus, farmakológus) Balla György (1953-) (csecsemő és gyermekgyógyász, neonatológus) Tósaki Árpád (1958-) (kísérletes farmakológus, gyógyszerész) Lekli István (1981-) (gyógyszerész)
Pályázati támogatás:OTKA-PD-111794
OTKA
NKFI-124719
NKFI
TÁMOP 4.2.4. A/2-11-1-2012-0001
TÁMOP
GINOP-2.3.2-15-2016-00043
GINOP
EFOP-3.6.1-16-2016-00022
EFOP
ÚNKP-17-4-III-DE-219
ÚNKP
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
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