Találati lista | Tudóstér

001-es BibID:	BIBFORM083676
035-os BibID:	(cikkazonosító)1352 (scopus)85079688785 (wos)000522524400179
Első szerző:	Mótyán János András (biokémikus, molekuláris biológus)
Cím:	Dimer Interface Organization is a Main Determinant of Intermonomeric Interactions and Correlates with Evolutionary Relationships of Retroviral and Retroviral-Like Ddi1 and Ddi2 Proteases / János András Mótyán, Márió Miczi, József Tőzsér
Dátum:	2020
ISSN:	1661-6596 1422-0067
Megjegyzések:	The life cycles of retroviruses rely on the limited proteolysis catalyzed by the viral protease. Numerous eukaryotic organisms also express endogenously such proteases, which originate from retrotransposons or retroviruses, including DNA damage-inducible 1 and 2 (Ddi1 and Ddi2, respectively) proteins. In this study, we performed a comparative analysis based on the structural data currently available in Protein Data Bank (PDB) and Structural summaries of PDB entries (PDBsum) databases, with a special emphasis on the regions involved in dimerization of retroviral and retroviral-like Ddi proteases. In addition to Ddi1 and Ddi2, at least one member of all seven genera of the Retroviridae family was included in this comparison. We found that the studied retroviral and non-viral proteases show differences in the mode of dimerization and density of intermonomeric contacts, and distribution of the structural characteristics is in agreement with their evolutionary relationships. Multiple sequence and structure alignments revealed that the interactions between the subunits depend mainly on the overall organization of the dimer interface. We think that better understanding of the general and specific features of proteases may support the characterization of retroviral-like proteases.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk retrovirus retrovirus-like protease retroviral protease dimerization comparative analysis contact map DNA damage-inducible protein Ddi1 Ddi2 HIV protease
Megjelenés:	International Journal of Molecular Sciences. - 21 : 4 (2020), p. 1-24. -
További szerzők:	Miczi Márió Tőzsér József (1959-) (molekuláris biológus, biokémikus, vegyész)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00044 GINOP NKFIH-1150-6/2019 Egyéb EFOP-3.6.3-VEKOP-16-2017-00009 EFOP
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat DOI
Borító:
Saját polcon: