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001-es BibID:BIBFORM084530
035-os BibID:(WoS)000383620000028 (Scopus)84987814942
Első szerző:Bertolini, Marta
Cím:Vasoactive intestinal peptide, whose receptor-mediated signalling may be defective in alopecia areata, provides protection from hair follicle immune privilege collapse / Bertolini M., Pretzlaff M., Sulk M., Bähr M., Gherardini J., Uchida Y., Reibelt M., Kinori M., Rossi A., Bíró T., Paus R.
ISSN:0007-0963 1365-2133
Megjegyzések:Background Alopecia areata (AA) is an autoimmune disorder whose pathogenesisinvolves the collapse of the relati ve immune privilege (IP) of the hair follicle(HF). Given that vasoactive intestinal peptide (VIP) is an immunoinhibitory neu-ropeptide released by perifollicular sensory nerve ?bres, which play a role in IPmaintenance, it may modulate human HF-IP and thus be therapeutically relevantfor AA.Objectives To answer the following questions: Do human HFs express VIP recep-tors, and does their stimulation protect from or restore experimentally inducedHF-IP collapse? Is VIP signalling defective in AA HFs?Methods Firstly, VIP and VIP receptor (VPAC1, VPAC2) expression in human scalpHFs and AA skin was assessed. In HF organ culture, we then explored whetherVIP treatment can restore and/or protect from interferon-c-induced HF-IP col-lapse, assessing the expression of the key IP markers by quantitative (immuno-)histomorphometry.Results Here we provide the ?rst evidence that VIP receptors are expressed in theepithelium of healthy human HFs at the gene and protein level. Furthermore,VIP receptor protein expression, but not VIP+nerve ?bres, is signi?cantly down-regulated in lesional hair bulbs of patients with AA, suggesting defects in VIPreceptor-mediated signalling. Moreover, we show that VIP protects the HF fromexperimentally induced IP collapse in vitro, but does not fully restore it once col-lapsed.Conclusions These pilot data suggest that insuf?cient VIP receptor-mediated sig-nalling may contribute to impairing HF-IP in patients with AA, and that VIP is apromising candidate ♭HF-IP guardian' that may be therapeutically exploited toinhibit the progression of AA lesions.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:British Journal Of Dermatology. - 175 : 3 (2016), p. 531-541. -
További szerzők:Pretzlaff, M. Sulk, M. Bähr, M. Gherardini, Jennifer Uchida, Yohei Reibelt, M. Kinori, M. Rossi, A. Bíró Tamás (1968-) (élettanász) Paus, Ralf
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