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001-es BibID:BIBFORM096053
Első szerző:Papp László Attila (genetikus)
Cím:Molecular and comparative genomic analyses reveal evolutionarily conserved and unique features of the Schizosaccharomyces japonicus mycelial growth and the underlying genomic changes / Papp László Attila, Ács-Szabó Lajos, Batta Gyula, Miklós Ida
Megjegyzések:Fungal pathogens, from phytopathogenic fungus to human pathogens, are able to alternate between the yeast-like form and filamentous forms. This morphological transition (dimorphism) is in close connection with their pathogenic lifestyles and with their responses to changing environmental conditions. The mechanisms governing these morphogenetic conversions are still not fully understood. Therefore, we studied the filamentous growth of the less-known, non-pathogenic dimorphic fission yeast, S. japonicus, which belongs to an ancient and early evolved branch of the Ascomycota. Its RNA sequencing revealed that several hundred genes were up- or down-regulated in the hyphae compared to the yeast-phase cells. These genes belonged to different GO categories, confirming that mycelial growth is a rather complex process. The genes of transport- and metabolic processes appeared especially in high numbers among them. High expression of genes involved in glycolysis and ethanol production was found in the hyphae, while other results pointed to the regulatory role of the protein kinase A (PKA) pathway. The homologues of 49 S. japonicus filament-associated genes were found by sequence alignments also in seven distantly related dimorphic and filamentous species. The comparative genomic analyses between S. japonicus and the closely related but non-dimorphic S. pombe shed some light on the differences in their genomes. All these data can contribute to a better understanding of hyphal growth and those genomic rearrangements that underlie it.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Bioinformatic analysis
Mycelial growth
Schizosaccharomyces japonicus
Transcriptional profiling
Megjelenés:Current Genetics. - 67 : 6 (2021), p. 953-968. -
További szerzők:Ács-Szabó Lajos (1985-) (biológus) Batta Gyula (1979-) (biológus) Miklós Ida (1962-) (biológus)
Pályázati támogatás:EFOP-3.6.1-16-2016-00022
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