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001-es BibID:	BIBFORM103610
035-os BibID:	(cikkazonosító)110978 (WOS)000522119300002 (Scopus)85077754827
Első szerző:	Guillou, Amaury
Cím:	Picolinate-appended tacn complexes for bimodal imaging: Radiolabeling, relaxivity, photophysical and electrochemical studies / Amaury Guillou, Margau Galland, Amandine Roux, Balázs Váradi, Réka Anna Gogolák, Patricia Le Saëc, Alain Faivre-Chauvet, Maryline Beyler, Christophe Bucher, Gyula Tircsó, Véronique Patinec, Olivier Maury, Raphaël Tripier
Dátum:	2020
ISSN:	0162-0134 1873-3344
Megjegyzések:	Based on our previous works involving two 1,4,7-triazacyclononane (tacn)-based ligands Hno2py1pa (1-Picolinic acid-4,7-bis(pyridin-2-ylmethyl)-1,4,7-triazacyclononane) and Hno1pa (1-Picolinic acid-1,4,7-triazacyclononane), we report here the synthesis of analogues bearing picolinate-based rz-conjugated ILCT (IntraLigand Charge Transfer) transition antenna (HL1, HL2), using regiospecific N-functionalization of the tacn skeleton and their related transition metal complexes (e.g. Cu2+, Zn2+ and Mn2+). Coordination properties as well as their photophysical and electrochemical properties were investigated in order to quantify the impact of such antenna on the luminescent or relaxometric properties of the complexes. The spectroscopic properties of the targeted ligands and metal complexes have been studied using UV-Vis absorption and fluorescence spectrocopies. While the zinc complex formed with HL1 possesses a moderate quantum yield of 5%, complexation of Cu2+ led to an extinction of the luminescence putatively attributed to a photo-induced electron transfer, as supported by spectroscopic and electrochemical evidences. The [Mn(L2)](+) complex is characterized by a fluorescence quantum yield close to 8% in CH2Cl2. The potential interest of such systems as bimodal probes has been assessed from radiolabeling experiments conducted on HL1 and( 64)Cu(2+) as well as confocal microscopy analyses and from relaxometric studies carried out on the cationic [Mn(L2)](+) complex. These results showed that HL1 can be used for radiolabeling, with a radiochemical conversion of 40% in 15 min at 100 degrees C. Finally, the relaxivity values obtained for [Mn(L2)](+), r(1p) = 4.80 mM(-1).s(-1) and r(2p) = 8.72 mM(-1).s(-1), make the Mn(II) complex an ideal candidate as a probe for Magnetic Resonance Imaging.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal of Inorganic Biochemistry. - 205 (2020), p. 1-9. -
További szerzők:	Galland, Margaux Roux, Amandine Váradi Balázs (1990-) (vegyész) Gogolák Réka Anna (kémia tanár) Le Saëc, Patricia Faivre-Chauvet, Alain Beyler, Maryline Bucher, Christophe Tircsó Gyula (1977-) (vegyész, kémia tanár) Patinec, Véronique Maury, Olivier Tripier, Raphaël
Pályázati támogatás:	NKFIH-K-120224 Egyéb GINOP-2.3.2-15-2016-00008 GINOP
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