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001-es BibID:	BIBFORM105854
035-os BibID:	(WOS)000605268701545
Első szerző:	Merzah, Mohammed
Cím:	Roma socioeconomic status has higher impact on smoking behaviour than genetic susceptibility / M. A. Merzah, P. Pikó, R. Ádány, S. Fiatal
Dátum:	2020
ISSN:	1101-1262
Megjegyzések:	Background: Prevalence of smoking in Hungarian Roma (HR) population is two to five times higher than in Hungarian general (HG) population. Our study aims to examine genetic susceptibility and other possible determinants associated to smoking behaviours in these populations. Methods: A questionnaire based cross-sectional study was designed in HG (N = 412) and HR (N = 402) populations. Ten Single Nucleotide Polymorphisms (SNPs) were genotyped known to be robustly linked to smoking behaviours. Risk allele frequencies were compared. Additive genetic risk scores (unweighted GRS and weighted GRS) were constructed to compare genetic load from SNPs in genes NRXN1, CHRNA5/. 4, AGPHD1, MAOA, TRPC7, KCNJ6, GABRA4, and CYP2A6. Smoking behaviour were associated with GRSs and confoun ders (age, gender, BMI, socioeconomic status-SES) in several regression models. SES was calculated based on Modified Kuppuswamy scale 2019. Results: Risk allele frequencies of four SNPs were found to be different between populations (p < 0.01). Median of GRS was equivalent among in populations; whilst wGRS median was slightly higher among Roma (5.2 compared to Hungarian 4.9; P = 0.02). In Roma both genders were more likely to be heavy smoker (OR = 2.05, 95%CI: 1.47-2.86; OR = 1.89, 95%CI: 1.58-2.25, for males and females, respectively) compared to counterparts from general population. GRS were higher among heavy smokers of both populations compared to other smoking behaviours (ORRoma= 1.06, 95%CI:0.98-1.15; ORHungarian=1.05, 95%CI=0.91-1.2). Strong reversible rela tionship was found between SES and smoking behaviours among study populations (p < 0.0001). Heavy, moderate, and former smokers were having lower SES compared to never smokers of both populations (SES =-0.037, P = 0.04 for Hungarian; =-0.039, P = 0.02 for Roma). Conclusions: Socioeconomic status was shown as a priority indicator based on multifactorial regression analysis. The highest efforts should be focused on improving the SES of Roma population.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	European Journal Of Public Health. - 30 : Suppl5 (2020), p. 321-322. -
További szerzők:	Pikó Péter (1987-) (biológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember)
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