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001-es BibID:BIBFORM105977
Első szerző:Fiatal Szilvia (epidemiológus, népegészségügyi szakember)
Cím:Evaluation of genetic risk related to high fasting glucose level in the Hungarian Roma population / Sz. Fiatal, V. Tomori, P. Pikó, Á. Moravcsik-Kornyicki, B. Soltész, A. Nagy, J. Sándor, R. Ádány
Megjegyzések:Background Studies showed that health status of Roma population, which represents the largest minority in Central and Eastern Europe, is significantly worse than that of the general population. It is recently pointed out that the prevalence of raised fasting plasma glucose or known type 2 diabetes mellitus (FPG/T2D) were significantly higher in all age groups in the Hungarian Roma (HR) population than in the Hungarian general (HG) population. Our aim was to identify whether a genetic susceptibility contributes to higher FPG/T2D in the HR population. Methods Eighteen single nucleotide polymorphisms were genotyped (Sequenom, MassARRAY platform) in 753 samples from the population of Roma and 1783 samples from the HG population. A genetic risk score (GRS), both unweighted and weighted were constructed for each individual and were compared using two sided t test. Considering the confounding effects of age, gender and BMI on differences in GRS between study populations, analysis of variance models were constructed. Results Although Roma people do not carry more risk alleles than Hungarians counterparts (20.5 2.8 vs. 20.3 2.9, P = 0.19), the average weighted GRS was significantly higher among them comparing to Hungarians (0.51 0.08 vs. 0.49 0.08, p = 4.8X10-4, respectively). This increase causes the distribution of genetic risk to be right-shifted in HR population compared to HG population. Adjustment for confounding factors did not change the inference of mean difference in weighted GRS (P = 5X10-3). Modelling of cumulative GRS suggested that the per-allele effect estimates are slightly also higher in HR than in HG population (OR= 1.1 vs. OR = 1.08, respectively). Conclusions GRS modelling showed that Roma individuals have greater burden of risk alleles compared to HG population. It suggests that there are ethnic specific differences in genetic architecture underlying raised FPG/T2D, which fosters the stratification of the Hungarian population according to T2D disease risk.
Tárgyszavak:Orvostudományok Egészségtudományok konferenciacikk
Megjelenés:European Journal Of Public Health. - 25 : suppl3 (2015), p. 136-137. -
További szerzők:Tomori Valéria Pikó Péter (1987-) (biológus) Moravcsik-Kornyicki Ágota (1986-) (védőnő) Soltész Beáta Nagy A. Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
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