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001-es BibID:	BIBFORM121026
035-os BibID:	(Scopus)85192759884
Első szerző:	Debreczeni-Máté Zsanett
Cím:	Recurrence Patterns after Radiotherapy for Glioblastoma with [(11)C]methionine Positron Emission Tomography-Guided Irradiation for Target Volume Optimization / Zsanett Debreczeni-Máté, Imre Törő, Mihaly Simon, Kristof Gál, Marton Barabás, David Sipos, Arpad Kovács
Dátum:	2024
ISSN:	2075-4418
Megjegyzések:	Abstract: 11C methionine (11C-MET) is increasingly being used in addition to contrast-enhanced MRI to plan for radiotherapy of patients with glioblastomas. This study aimed to assess the recurrence pattern quantitatively. Glioblastoma patients undergoing 11C-MET PET examination before primary radiotherapy from 2018 to 2023 were included in the analysis. A clinical target volume was manually created and fused with MRI-based gross tumor volumes and MET PET-based biological target volume. The recurrence was noted as an area of contrast enhancement on the first MRI scan, which showed progression. The recurrent tumor was identified on the radiological MR images in terms of recurrent tumor volume, and recurrences were classified as central, in-field, marginal, or ex-field tumors. We then compared the MET-PET-defined biological target volume with the MRI-defined recurrent tumor volume regarding spatial overlap (the Dice coefficient) and the Hausdorff distance. Most recurrences occurred locally within the primary tumor area (64.8%). The mean Hausdorff distance was 39.4 mm (SD 32.25), and the mean Dice coefficient was 0.30 (SD 0.22). In patients with glioblastoma, the analysis of the recurrence pattern has been mainly based on FET-PET. Our study confirms that the recurrence pattern after gross tumor volume-based treatment contoured by MET-PET is consistent with the FET-PET-based treatment described in the literature.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk 11C MET PET glioblastoma recurrence pattern
Megjelenés:	Diagnostics. - 14 : 9 (2024), p. 1-12. -
További szerzők:	Törő Imre Simon Mihály Gál Kristóf (1994-) (orvos) Barabás Márton Sipos Dávid Kovács Árpád (1979-) (onkoradiológus, klinikai onkológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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