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001-es BibID:	BIBFORM088388
035-os BibID:	(cikkazonosító)7063 (Scopus)85092778560 (WOS)000585101300001
Első szerző:	Hajdu Péter (gyorsító üzemeltető mérnök)
Cím:	Optimized Size and Distribution of Silver Nanoparticles on the Surface of Titanium Implant Regarding Cell Viability / Hajdu Péter, Lampé István, Rácz Richárd, Biri Sándor, Csík Attila, Tóth Ferenc, Szalóki Melinda, Hegedűs Viktória, Dombrádi Zsuzsanna, Varga István, Csarnovics István, Kökényesi Sándor, Beke Dezső László, Hegedűs Csaba
Dátum:	2020
ISSN:	2076-3417
Megjegyzések:	Though the antibacterial effect is advantageous, silver and silver nanoparticles can negatively affect the viability of human tissues. This study aims to check the viability of cells on surfaces with different particle size and to find the biologically optimal configuration. We investigated the effect of modified thickness of vaporized silver and applied heat and time on the physical characteristics of silver nanoparticle covered titanium surfaces. Samples were examined by scanning electron microscopy, mass spectrometry, and drop shape analyzer. To investigate how different physical surface characteristics influence cell viability, Alamar Blue assay for dental pulp stem cells was carried out. We found that different surface characteristics can be achieved by modifying procedures when creating silver nanoparticle covered titanium. The size of the nanoparticles varied between 60 to 368 nm, and hydrophilicity varied between 63 and 105 degrees of contact angle. Investigations also demonstrated that different physical characteristics are related to a different level of viability. Surfaces covered with 60 nm particle sizes proved to be the most hydrophilic, and the viability of the cells was comparable to the viability measured on the untreated control surface. Physical and biological characteristics of silver nanoparticle covered titanium, including cell viability, have an acceptable level to be used for antibacterial effects to prevent periimplantitis around implants.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk silver nanoparticles antibacterial effect periimplantitis cell viability
Megjelenés:	Applied Sciences-Basel. - 10 : 20 (2020), p. 1-13. -
További szerzők:	Lampé István (1960-) (fogszakorvos) Rácz Richárd (1985-) (fizikus) Biri Sándor Csik Attila (1975-) (fizikus) Tóth Ferenc (1980-) (molekuláris biológus) Szalóki Melinda (1981-) (vegyész) Hegedűs Viktória (1986-) (fogorvos) Dombrádi Zsuzsanna Rita (1983-) (molekuláris biológus, mikrobiológus) Varga István (1974-) (fogszakorvos) Csarnovics István (1986-) (fizikus) Kökényesi Sándor (1946-) (fizikus) Beke Dezső László (1945-) (fizikus) Hegedűs Csaba (1953-) (fogszakorvos)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00011 GINOP GINOP-2.3.2-15-2016-00022 GINOP GINOP-2.3.2-15-2016-00041 GINOP GINOP-2.3.3-15-2016-00029 GINOP NKFIH-1150-6/2019 NKFIH
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001-es BibID:	BIBFORM078596
035-os BibID:	(WoS)000470110300008 (Scopus)85065424299
Első szerző:	Martos Renáta (fogszakorvos)
Cím:	A randomised controlled study on the effects of different surface treatments and adhesive self-etch functional monomers on the immediate repair bond strength and integrity of the repaired resin composite interface / Martos Renata, Hegedüs Viktória, Szalóki Melinda, Blum Igor R., Lynch Christopher D., Hegedüs Csaba
Dátum:	2019
ISSN:	0300-5712
Megjegyzések:	Objectives: To evaluate the effects of different surface conditioning methods on the immediate repair bond strength and integrity of the repaired composite interface. Methods: One hundred and five resin composite blocks made of a nanohybrid resin composite were randomly assigned to one of the following surface conditioning groups (n=15/group): Group 1: Gluma Self Etch? adhesive system, Group 2: Tokuyama Bond Force II? adhesive system, Group 3: non-roughened and non-conditioned surfaces, Group 4: sandblasting and Gluma Self Etch?, Group 5: sandblasting and Tokuyama Bond Force II?, Group 6: sandblasting only. A positive control group was also used. Resin composite identical to the substrate was applied and the repaired specimens were subjected to shear bond strength (SBS) testing. Representative samples from all groups were subjected to scanning electron microscopy and surface profilometry to determine their mode of failure. The data were analysed statistically using Analysis of Variance (ANOVA) and two independent sample t test (?=0.05). Results: The mean SBS of all test groups ranged between 1.92 and 5.40 MPa and varied with the degree of composite surface roughness and the type of adhesive system employed. Significantly highest SBS values (5.40 ? 0.36 MPa) were obtained in Group 5 (p=0.017) which were comparable to the coherent strength of the resin composite in the positive control group (p>0.05). Conclusions: Under the tested conditions, significantly greater SBS of repaired resin composite was achieved when the substrate surface was conditioned by sandblasting followed by the application of the Tokuyama Bond Force II? adhesive system. Clinical significance: Effecting a repair of a nanohybrid composite restoration with sandblasting and the application of TBF II would seem to enhance the interfacial bond strength and integrity of the repaired resin composite interface. Clinical trials are necessary to determine the usefulness of this technique.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Nanohybrid composite repair Minimally invasive dentistry Shear bond strength
Megjelenés:	Journal Of Dentistry. - 85 (2019), p. 57-63. -
További szerzők:	Hegedűs Viktória (1986-) (fogorvos) Szalóki Melinda (1981-) (vegyész) Blum, Igor R. Lynch, Christopher D. Hegedűs Csaba (1953-) (fogszakorvos)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00011 GINOP GINOP-2.3.2-15-2016-00022 GINOP 20428-3/2018/FEKUTSTRAT Egyéb
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001-es BibID:	BIBFORM089017
035-os BibID:	(cikkazonosító)7742 (Scopus)85095421438 (WOS)000588974200001
Első szerző:	Szalóki Melinda (vegyész)
Cím:	Evaluation of the Effect of the Microscopic Glass Surface Protonation on the Hard Tissue Thin Section Preparation / Szalóki Melinda, Hegedűs Viktória, Fodor Tamás, Martos Renáta, Radics Tünde, Hegedűs Csaba, Dezső Balázs
Dátum:	2020
ISSN:	2076-3417
Megjegyzések:	In this study, a new procedure for mounting tissue blocks was described while cutting and grinding the section remains tightly bound to the inert glass surface both chemically and micro mechanically allowing good quality specimens for staining and microscopic analysis. The micromechanical interlocking was achieved by using of frosted glass, the chemical binding was made with 10-methacryloyloxydecyl dihydrogen phosphate monomer (10-MDP) containing bond material. The glass surface activation was achieved by nitric acid etching and the surface was characterized by zeta potential, X-ray photoelectron spectroscopy (XPS), and contact angle measurements. Cylindrical samples were prepared from epoxy embedding materials, cortical bovine bone, and dental titanium to investigate the shear bond strengths (SBS) to microscopic glass slide compared to a routinely used thermoplastic adhesive. Based on the experiments it was found that the micromechanical retention combined with MDP containing bond material improved the SBS data compared to the thermoplastic adhesive. The acid etched glass became positively charged that significantly increased the SBS data of bone and titanium compared with the uncharged version. Therefore, the thickness of the undecalcified bone section with metal can safely reduce to improve histological microscopic analysis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk microscopic glass surface protonation nitric acid etching undecalcified thin bone section titanium implant 10-MDP adhesion
Megjelenés:	Applied Sciences-Basel. - 10 : 21 (2020), p. 1-21. -
További szerzők:	Hegedűs Viktória (1986-) (fogorvos) Fodor Tamás (1984-) (Ph.D hallgató) Martos Renáta (1975-) (fogszakorvos) Radics Tünde (1963-) (egyetemi adjunktus, fogszakorvos) Hegedűs Csaba (1953-) (fogszakorvos) Dezső Balázs (1951-) (pathológus)
Pályázati támogatás:	GINOP-2.3.2.-15-2016-00011 GINOP GINOP-2.3.2.-15-2016-00022 GINOP GINOP-2.3.2.-15-2016-00041 GINOP
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