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001-es BibID:BIBFORM058137
Első szerző:Bagi Zsolt (orvos)
Cím:Type 2 diabetic mice have increased arteriolar tone and blood pressure : enhanced release of COX-2-derived constrictor prostaglandins / Zsolt Bagi, Nora Erdei, Attila Toth, Wei Li, Thomas H. Hintze, Akos Koller, Gabor Kaley
Megjegyzések:OBJECTIVE: Type 2 diabetes mellitus (T2-DM) is frequently associated with vascular dysfunction and elevated blood pressure, yet the underlying mechanisms are not completely understood. We hypothesized that in T2-DM, the regulation of peripheral vascular resistance is altered because of changes in local vasomotor mechanisms. METHODS AND RESULTS: In mice with T2-DM (C57BL/KsJ-(db-)/db-), systolic and mean arterial pressures measured by the tail cuff method were significantly elevated compared with those of control (db+/db-) animals (db/db, 146+/-5 and 106+/-2 mm Hg versus control, 133+/-4 and 98+/-4 mm Hg, respectively; P<0.05). Total peripheral resistance, calculated from cardiac output values (measured by echocardiography) and mean arterial pressure were significantly elevated in db/db mice (db/db, 25+/-6 versus control, 15+/-1 mm Hg[middot]mL(-1)[middot]min(-1)). In isolated, pressurized gracilis muscle arterioles (diameter approximately 80 microm) from db/db mice, stepwise increases in intraluminal pressure (from 20 to 120 mm Hg) elicited a greater reduction in diameter than in control vessels at each pressure step (at 80 mm Hg, db/db, 66+/-4% versus control, 79+/-3%). The passive diameters of arterioles (obtained in Ca2+-free solution) and the calculated myogenic index were not significantly different in the 2 groups. The presence of the prostaglandin H2/thromboxane A2 receptor antagonist SQ29548 did not affect arteriolar diameters of control mice but reduced the enhanced arteriolar tone of db/db mice back to control levels (at 80 mm Hg, 80+/-4%). The inhibitor of cyclooxygenase-1 (COX-1), SC-560, did not affect the basal tone of arterioles, whereas NS-398, an inhibitor of COX-2, caused a significant shift in the arteriolar pressure-diameter curve of vessels from db/db mice (at 80 mm Hg, 76+/-3%) but not in those of control mice. Also, in aortas of db/db mice, expression of COX-2 was enhanced compared with controls. CONCLUSIONS: Collectively, these findings suggest that in mice with T2-DM, the basal tone of skeletal muscle arterioles is increased because of an enhanced COX-2-dependent production of constrictor prostaglandins. These alterations in microvascular prostaglandin synthesis may contribute to the increase in peripheral resistance and blood pressure in T2-DM.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Arteriosclerosis Thrombosis and Vascular Biology. - 25 : 8 (2005), p. 1610-1616. -
További szerzők:Erdei Nóra (1979-) (orvos) Tóth Attila (1971-) (biológus) Li, Wei (1987-) (kutató) Hintze, Thomas H. Koller Ákos Kaley Gábor
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001-es BibID:BIBFORM074228
Első szerző:Fülöp Tibor (kardiológus)
Cím:Adaptation of Vasomotor Function of Human Coronary Arterioles to the Simultaneous Presence of Obesity and Hypertension / Tibor Fulop, Eva Jebelovszki, Nora Erdei, Tamas Szerafin, Tamas Forster, Istvan Edes, Akos Koller, Zsolt Bagi
Megjegyzések:Objectives: We hypothesized that simultaneous presence of obesity and hypertension activates adaptive vascular mechanisms affecting dilations of human coronary arterioles.Methods and Results: Agonist-induced dilations were assessed in isolated pressurized coronary arterioles from patients(n 38) who underwent cardiac surgery. Among normotensives we found that dilations to bradykinin (BK) and the NO-donor, sodium-nitroprusside (SNP) were reduced in obese subjects (BK, 10 7 mol/L, lean:90 4%, obese:64 7%; SNP, 10 6 mol/L, lean:89 7%, obese:76 5%). However, among hypertensives, both BK- and SNP-induced dilations were significantly enhanced in obese patients, when compared with lean individuals (BK, lean:71 7%, obese:85 3%; SNP, lean:60 6%, obese:83 2%). Correspondingly, in hypertensive patients, but not in those of normotensives, a positive correlation was found between body mass index (BMI) and BK-induced (P 0.036, r 0.46), and also SNP-evoked (P 0.031, r 0.44) coronary dilations. Moreover, in additional 55 hypertensive patients flow-mediated (FMD) and nitroglycerin (NTG)-induced dilations of the brachial artery were assessed. In obese hypertensive individuals, FMD- and NTG-induced dilations were greater (FMD:6.2 0.7%, NTG:17.2 0.9%), than in leanhypertensive patients (FMD:3.7 0.6%, NTG:13.6 1.1%). Correspondingly, FMD- and NTG-induced dilations were positively correlated with BMI (P 0.020, r 0.31 and P 0.033, r 0.29, respectively).Conclusions:These findings are the first to suggest that obesity may lead to activation of adaptive vascular mechanisms to enhance the dilator function of coronary and peripheral arterial vessels in hypertensive patients. (Arterioscler Thromb Vasc Biol. 2007;27:2348-2354.)
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
coronary microcirculation
flow-mediated dilation
Megjelenés:Arteriosclerosis Thrombosis And Vascular Biology. - 27 : 11 (2007), p. 2348-2354. -
További szerzők:Jebelovszki Éva Erdei Nóra (1979-) (orvos) Szerafin Tamás (1960-) (szívsebész, mellkassebész) Forster Tamás Édes István (1952-) (kardiológus) Koller Ákos Bagi Zsolt (1974-) (orvos)
Pályázati támogatás:F-048837
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Intézményi repozitóriumban (DEA) tárolt változat
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