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001-es BibID:BIBFORM003485
Első szerző:Puskás László G.
Cím:Gene profiling identifies genes specific for well-differentiated epithelial thyroid tumors / Puskas L. G., Juhasz F., Zarva A., Hackler L. Jr., Farid N. R.
Megjegyzések:Thyroid nodules are common. It would be very helpful if genetic markers that can diagnose malignancy from fine needle aspiration samples were available. Few such markers have been thus identified and none are specific. Large panels of potential markers can be screened by microarray technology. Studies done to date have concentrated on single tumor types and thus provide no help in identifying tumor subtype specific markers. To that end we have studied gene profiles of 5 types of benign and malignant thyroid nodular tissue (multinodular goiter, follicular adenomas, papillary and follicular carcinomas). We have identified 195 genes whose differential expression clustered into clinically relevant groups. Twenty-eight genes were selected for further confirmation using real time quantitative polymerase chain reaction. Despite the differences in the microarray panels used, we confirmed the differential regulation of 12 genes previously reported in thyroid cancer, although we found the expression of several gene to be regulated in other histological tumor subtypes than originally described. We found, PCSK2, TRIB1, RAP1 GA1 to be specifically overexpressed in follicular cancer and S100A4 and GK2 in papillary carcinoma. SERP1, RNASE2 and STATA5 were suppressed in papillary thyroid cancer. We have thus identified new potential markers specific to malignant thyroid tumors. It is apparent that a range of nodular thyroid tissue using large tumor sample numbers is necessary to establish robust markers for malignancy and to categorize tumors on the basis of small tumor samples. Running title: Gene expression in thyroid cancer.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
gene profiling
fine needle biopsy
follicular carcinoma
papillary carcinoma
follicular adenoma
multinodular goitre
Megjelenés:Cellular and molecular biology (Noisy-le-Grand, France). - 51 : 2 (2005), p. 177-186. -
További szerzők:Zarva Ágnes Hackler László Jr. Farid, Nadir R. Juhász Ferenc (1952-) (sebész)
Internet cím:elektronikus változat
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