Összesen 3 találat.


001-es BibID:BIBFORM016143
Első szerző:Babick, Andrea P.
Cím:Sarcolemmal Remodeling in Heart Failure Due to Myocardial Infarction / Andrea Babick, Judit Barta, Naranjan S. Dhalla
Megjegyzések:Moderate degree of congestive heart failure (CHF) upon occluding coronary artery has been shown to be associated with a depression in the sarcolemmal (SL) Na+-K+ ATPase activity, as well as differential changes in mRNA levels and protein contents for different SL Na+-K+ ATPase isozymes. Likewise, the decreased SL Na+-Ca2+ exchanger activity was accompanied by depressed gene expression and protein content. Although the number of SL Ca2+-channels in the failing heart was decreased, no change in SL Ca2+-pump activity was evident. Such observations indicate that the SL membrane becomes remodeled during the development of CHF due to myocardial infarction.
Tárgyszavak:Orvostudományok Elméleti orvostudományok előadáskivonat
Megjelenés:Advances in Heart Disease : Proceedings of the 12th World Congress on Heart Disease ? New Trends in Research, Diagnosis and Treatment / ed. Asher Kimchi. - p. 3-10
További szerzők:Barta Judit (1975-) (kardiológus) Dhalla, Naranjan S.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat


001-es BibID:BIBFORM015748
Első szerző:Barta Judit (kardiológus)
Cím:Modulation of renin-angiotensin system : applications in clinical cardiology / Barta Judit, Andrea P. Babick, David P. Brasil, Naranjan S. Dhalla
Tárgyszavak:Orvostudományok Elméleti orvostudományok könyvfejezet
Megjelenés:Contemporary Perspectives on Clinical Pharmacotherapeutics / eds. K. Kohli, M. Gupta, S. Tejawani. - p. 253-267
További szerzők:Babick, Andrea P. Brasil, David P. Dhalla, Naranjan S.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat


001-es BibID:BIBFORM005640
Első szerző:Sanganalmath, Santosh K.
Cím:Antiplatelet therapy attenuates subcellular remodelling in congestive heart failure / Sanganalmath, S. K., Babick, A. P., Barta, J., Kumamoto, H., Takeda, N., Dhalla, N. S.
ISSN:1582-1838 (Print)
Megjegyzések:Antiplatelet agents, sarpogrelate (SAR), a 5-HT(2A) receptor antagonist, and cilostazol (CIL), a phosphodiesterase III (PDE-III) inhibitor, are used for the treatment of peripheral vascular disease. We tested whether these agents affect cardiac function and subcellular remodelling in congestive heart failure (CHF) induced by myocardial infarction (MI). Three weeks after MI, rats were treated daily with 5 mg/kg SAR or CIL as well as vehicle for 5 weeks. Sham-operated animals served as controls. At end of the treatment period, haemodynamic measurements were performed and the left ventricle was processed for the determination of sarcoplasmic reticulum (SR) Ca(2+)-uptake and -release activities, and expression of SR Ca(2+)-pump, phospholamban and ryanodine receptors, as well as myofibrillar ATPase activities, expression of alpha- and beta-myosin heavy chain (MHC) isoforms, and phosphorylation of phospholamban and cardiac troponin-I (c Tn-I). Marked haemodynamic changes in the MI-induced CHF were associated with depressions in SR Ca (+)-uptake and -release activities as well as in protein content and gene expression for SR proteins. Furthermore, myofibrillar Ca(2+)-stimulated ATPase activity, as well as protein content and gene expression for alpha-MHC were decreased whereas those for beta-MHC were increased in the failing heart. Also, phosphorylation levels of phospholamban and cTn-I were reduced in failing hearts. The MI-associated changes in cardiac function, SR and myofibillar activities, as well as SR and myofibrillar protein and gene expression were attenuated by treatment with SAR or CIL. The results suggest that SAR and CIL improve cardiac function by ameliorating subcellular remodelling in the failing heart and indicate the potential therapy of CHF with antiplatelet agents.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Adenosine Triphosphatases/metabolism
Blood Platelets
Gene Expression Regulation
Heart Failure/genetics/metabolism/surgery/ therapy
Myosin Heavy Chains/metabolism
Protein Isoforms/metabolism
RNA, Messenger/genetics
Rats, Sprague-Dawley
Sarcoplasmic Reticulum/metabolism
Subcellular Fractions/metabolism
Megjelenés:Journal of Cellular and Molecular Medicine. - 12 : 5A (2008), p. 1728-1738. -
További szerzők:Babick, Andrea P. Barta Judit (1975-) (kardiológus) Kumamoto, Hideo Takeda, Nobuakiya Dhalla, Naranjan S.
Internet cím:DOI
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