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001-es BibID:BIBFORM015749
Első szerző:Barta Judit (kardiológus)
Cím:Myofibrillar Remodeling During the Development of Ischemic Heart Disease / Barta Judit, Raja B. Singh, Srilekha Maddika, Rajat Sethi, Naranjan S. Dhalla
Megjegyzések:Ischemic heart disease (IHD) resulting from insufficient supply of O2 and nutrients is one of the major causes of moitality and morbidity in the developed as well as developing countries. Extensive studies on IHD haverevealed alterations at the cellular, subcellular and molecular levels in the ischemic cardiac muscle. It is generally believed that both the occurrences of oxidativestress and the development of intracellular calcium (Ca2+) overload are important mechanisms of cardiac dysfunction and injury to myocardium in the IHD. Myofibrílar proteins, which form an essential part of contractile machinery ofthe heart and determine the cardiac contractile activity have been shown to exhibit changes in their assembly as well as activities under a wide variety of conditions associated with IHD. The present article is aimed to provide an insight into the assembly of myofibrilar proteins and alterations in their biochemical activities to emphasize the significance of myofibrillar remodeling(changes in structure and function) in hearts subjected to ischemia as well as reperfusion. It is proposed that myofibrillar remodeling plays an important role in cardiac dysftrnction in IHD.
Tárgyszavak:Orvostudományok Elméleti orvostudományok könyvfejezet
Ischemic heart disease
myofibrillar remodeling
ischemia-reperfusion injury
Megjelenés:Recent Advances in Cardiovascular Sciences / ed. S.S. Agrawal. - p. 42-62
További szerzők:Singh, Raja B. Maddika, Srilekha Sethi, Rajat Dhalla, Naranjan S.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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