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001-es BibID:BIBFORM018113
Első szerző:Engström, Karl Gunnar
Cím:Impaired contractility of left-over vein grafts used for CABG and the possible trauma caused by air exposure / Karl Gunnar Engström, Istvan Szentkiralyi
Megjegyzések:The patency of vein grafts limits the long-term results after bypass surgery. Vein graft trauma may contribute to the clinical results. DESIGN: Left-over pieces of vein after routine coronary bypass surgery were compared with references of the same vein that were stored with maximum care. Blood perfusion (20 h, 37 degrees C) was also tested to evaluate possible recovery. Vessel rings were measured by isometric tone recordings. RESULTS: Left-over veins showed a contractile dysfunction compared to reference (p < 0.01-0.001, n = 13), and that did not recover after blood perfusion. Four trauma models were tested, using saphenous vein graft (SVG)-references (n = 5). Chemical exposures (0-90 min) to NaCl-papaverin or cardioplegic medium affected the baseline (p < 0.05-0.01). With mechanical distension, up to 450 mmHg leak testing, an increased norepinephrine (NE) reactivity appeared. Air contact, 20 min, reduced the NE reactivity to half maximum (p < 0.05). Longer exposures (40-60 min) completely abolished the contractility. CONCLUSIONS: The saphenous vein smooth muscle function appeared permanently traumatized following routine harvesting and handling. Air exposure gave dramatic deterioration and could in theory contribute to hamper the long-term results after bypass surgery.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Scandinavian Cardiovascular Journal . - 35 : 6 (2001), p. 403-408. -
További szerzők:Szentkirályi István (1970-) (szívsebész)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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