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001-es BibID:BIBFORM008929
Első szerző:Kis Andrea (molekuláris biológus, mikrobiológus)
Cím:Epstein-Barr virus prevalence in oral squamous cell cancer and in potentially malignant oral disorders in an eastern Hungarian population / Kis Andrea, Fehér Enikő, Gáll Tamás, Tar Ildikó, Boda Róbert, D. Tóth Etelka, Méhes Gábor, Gergely Lajos, Szarka Krisztina
Megjegyzések:We tested 65, 44, and 116 patients with oral squamous cell cancer (OSCC), oral leukoplakia (OL), and oral lichen planus (OLP) against 68 age-matched controls for the presence of Epstein-Barr virus (EBV). Apparently healthy mucosa was simultaneously sampled and examined in all patients. Paraffin-embedded tissue sections of all EBV-positive patients with OSCC were examined for latent membrane protein-1 (LMP-1) expression (demonstrable in most EBV-associated malignancies) using immunohistochemistry. The prevalence of EBV in the controls and in OSCC, OL, and OLP lesions was 19.1%, 73.8%, 29.5%, and 46.6%, respectively, and 66.2%, 22.7%, and 31.9% in the healthy mucosa of patients, respectively. The prevalence of EBV in OSCC patients was significantly higher than in controls or in respective samples of the other two patient groups both in the lesion and in the healthy mucosa. Comparisons including only patients with EBV-negative lesions yielded similar results. Lesions of patients with OLP, but not of patients with OL, differed significantly from controls in EBV prevalence. In OSCC, LMP-1 expression was not detected, and EBV carriage was not significantly associated with any risk factors and did not influence the outcome. Although a high prevalence of EBV was found in OSCC, comparable carriage rates on healthy mucosa of patients indicated that an aetiological role of EBV is unlikely.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Epstein-Barr virus
egyetemen (Magyarországon) készült közlemény
Megjelenés:European Journal of Oral Sciences. - 117 : 5 (2009), p. 536-540. -
További szerzők:Fehér Enikő (1981-) (molekuláris biológus, mikrobiológus) Gáll Tamás (1982-) (molekuláris biológus, mikrobiológus) Tar Ildikó (1967-) (fogszakorvos) Boda Róbert (1978-) (fogszakorvos) D. Tóth Etelka (1975-) (fogszakorvos) Méhes Gábor (1966-) (patológus) Gergely Lajos (1940-) (szakorvos, klinikai mikrobiológus) Szarka Krisztina (1971-) (molekuláris biológus, mikrobiológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat


001-es BibID:BIBFORM008946
Első szerző:Szarka Krisztina (molekuláris biológus, mikrobiológus)
Cím:Progressive increase of human papillomavirus carriage rates in potentially malignant and malignant oral disorders with increasing malignant potential / Szarka Krisztina, Tar Ildikó, Fehér Enikő, Gáll Tamás, Kis Andrea, D. Tóth Etelka, Boda Róbert, Márton Ildikó, Gergely Lajos
Megjegyzések:We investigated the potential role of human papillomaviruses (HPVs) in potentially malignant oral disorders, oral leukoplakia (OL) and oral lichen planus (OLP), and in oral squamous cell cancer (OSCC) in an Eastern Hungarian population with a high incidence of OSCC. Methods: Excised tumor samples (65 OSCC patients) and exfoliated cells from potentially malignant lesions (from 44 and 119 patients with OL and OLP, respectively) as well as from healthy controls (72 individuals) were analysed. OLPs were classified based on clinical appearance, 61 patients had erosive?atrophic lesions (associated with higher malignancy risk, EA-OLP) and 58 had non-erosive non-atrophic lesions (with lower risk of becoming malignant, non-EA-OLP), respectively. Exfoliated cells collected from apparently healthy mucosa accompanied each lesion sample. HPV was detected by MY/GP polymerase chain reaction (PCR) and genotyped by restriction analysis of amplimers. Copy numbers in lesions were determined using real-time PCR. Prevalence rates, copy number distributions, and association with risk factors and diseases were analysed using chi-square test, t-test, and logistic regression, respectively. Results: We detected HPVs significantly more frequently in lesions than in controls (P ? 0.001 in all comparisons). HPV prevalence increased gradually with increasing severity of lesions (32.8, 40.9, and 47.7% in OLP, OL, and OSCC, respectively). Copy number distribution patterns roughly corresponded to prevalence rates, but OLP and OL were comparable. HPV prevalence differed significantly between EA-OLP and non-EA-OLP groups (42.6 vs. 22.4%); EA-OLP group showed a prevalence similar to that found in OL. Conclusion: HPVs may be involved in the development or progression of not only OSCC but also of potentially malignant oral lesions.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
human papillomavirus
oral carcinogenesis
Megjelenés:Oral Microbiology and Immunology 24 : 4 (2009), p. 314-318. -
További szerzők:Tar Ildikó (1967-) (fogszakorvos) Fehér Enikő (1981-) (molekuláris biológus, mikrobiológus) Gáll Tamás (1982-) (molekuláris biológus, mikrobiológus) Kis Andrea (1981-) (molekuláris biológus, mikrobiológus) D. Tóth Etelka (1975-) (fogszakorvos) Boda Róbert (1978-) (fogszakorvos) Márton Ildikó (1954-) (fogszakorvos) Gergely Lajos (1940-) (szakorvos, klinikai mikrobiológus)
Internet cím:elektronikus változat
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