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1.

001-es BibID:BIBFORM093762
Első szerző:Csikós Anett (biomérnök, biológia-földrajz tanár)
Cím:Differential expression of zinc transporters in vaginal tissues / A. Csikós, B. Kozma, I. Miklós, A. Pór, I. Kovács, R. Lampé, P. Takács
Dátum:2020
Tárgyszavak:Orvostudományok Elméleti orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:Female Pelvic Medicine & Reconstructive Surgery. - 26 : 10S-Suppl1 (2020), p. S127. -
További szerzők:Kozma Bence (1982-) (szülész-nőgyógyász) Miklós Ida (1962-) (biológus) Pór Ágnes Kovács Ilona Lampé Rudolf (1983-) (szülész-nőgyógyász) Takács Péter (1968-) (szülész-nőgyógyász)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM091543
Első szerző:Csikós Anett (biomérnök, biológia-földrajz tanár)
Cím:Evaluation of zinc and copper levels in vaginal tissues and whole blood : correlation with age / Csikós Anett, Kozma Bence, Baranyai Edina, Miklós Ida, Larson Kindra, Póka Róbert, Takacs Peter
Dátum:2021
ISSN:1472-6874
Megjegyzések:Background: Zinc and copper are essential trace elements and play a crucial role in the homeostasis of connective tissues. In this study, we aimed to define zinc and copper levels in the vaginal tissue and establish whether a correlation exists between the zinc and copper levels either or both in whole blood or vaginal tissue samples and whether the finding correlates with the age of the patient or at least with her menopausal status. Methods: We collected whole blood and vaginal tissue samples from 32 women and measured their zinc and copper levels by inductively coupled plasma optical emission spectrometry. We have performed Student's t test to evaluate the differences in the mean levels of trace elements and multiple regression to evaluate the association between vaginal tissue zinc/copper levels and age, menopausal status, number of vaginal deliveries, and zinc/copper blood levels. Results: Zinc levels were significantly higher in both the vaginal tissues and whole blood samples than copper levels (p?<?0.01). In the vaginal tissue samples, a strong positive correlation could be detected between zinc and copper levels (r?=?0.82, p?<?0.01). In the vaginal tissue, a negative correlation was found for zinc and copper levels with the age of women (r?=???0.27, p?=?0.04 and r?=???0.56, p?<?0.01). Multiple linear regression model (age, menopausal status, vaginal delivery and copper/zinc blood levels) showed that only age remained a significant predictor for zinc and copper vaginal tissues levels (p?=?0.03, 95% CI ??2.28 to ??0.06; p?=?0.004, 95% CI ??1.76 to ??0.34). Conclusions: Zinc and copper levels in the vaginal tissue decline with age. Out of the examined variables (age, menopausal status, vaginal delivery, and copper/zinc levels), only age is a significant predictor of vaginal zinc/copper levels.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Ageing
Cooper
ICP-OES
Vagina
Whole blood
Zinc
Megjelenés:BMC Women's Health. - 21 : 1 (2021), p. 1-7. -
További szerzők:Kozma Bence (1982-) (szülész-nőgyógyász) Baranyai Edina (1987-) (környezetkutató) Miklós Ida (1962-) (biológus) Larson, Kindra Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus) Takács Péter (1968-) (szülész-nőgyógyász)
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3.

001-es BibID:BIBFORM090310
Első szerző:Csikós Anett (biomérnök, biológia-földrajz tanár)
Cím:Zinc Transporter 9 (SLC30A9) Expression Is Decreased in the Vaginal Tissues of Menopausal Women / Csikós Anett, Kozma Bence, Pór Ágnes, Kovács Ilona, Lampé Rudolf, Miklós Ida, Takacs Peter
Dátum:2021
ISSN:0163-4984
Megjegyzések:Our aim was to compare zinc transporter (ZnT/SLC30A, and ZIP/SLC39A) expression between pre- and postmenopausal women in human vaginal tissues. Zinc transporter families are responsible for the maintenance of intracellular zinc concentrations. Zinc has significant effects on the extracellular matrix composition. Vaginal wall biopsies were obtained from seven premenopausal and seven postmenopausal women. mRNA expression of twenty-four zinc transporters was determined by quantitative real-time PCR. Zinc transporter expression at the protein level was assessed by immunohistochemistry. Student's t test and Mann-Whitney U test were used to compare data. ZnT4 and ZnT9 mRNA expression were significantly lower in postmenopausal women compared with premenopausal women (mean ? SD mRNA expression in relative units, 96.43 ? 140.61 vs. 410.59 ? 304.34, p = 0.03 and 0.62 ? 0.39 vs. 1.13 ? 0.31, p = 0.02). In addition, ZIP2, ZIP3, and ZIP6 mRNA expressions were significantly lower in postmenopausal women compared with premenopausal women (mean ? SD mRNA expression in relative units, 1.11 ? 0.61 vs. 2.29 ? 1.20, p = 0.04; 2.32 ? 1.90 vs. 15.82 ? 12.97, p = 0.02 and 1.10 ? 0.80 vs. 5.73 ? 4.72, p = 0.03). ZnT9 protein expression in the stratum spinosum was significantly lower in postmenopausal women (p = 0.012). Zinc transporters were expressed differentially in the vaginal tissues. ZnT9 expression was significantly lower in postmenopausal women compared with premenopausal women.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Gene expression
Menopause
Vagina
ZIPs
ZnTs
Megjelenés:Biological Trace Element Research. - 199 : 11 (2021), p. 4011-4019. -
További szerzők:Kozma Bence (1982-) (szülész-nőgyógyász) Pór Ágnes Kovács Ilona (1965-) (patológus) Lampé Rudolf (1983-) (szülész-nőgyógyász) Miklós Ida (1962-) (biológus) Takács Péter (1968-) (szülész-nőgyógyász)
Pályázati támogatás:GINOP-2.1.1-15-2016-00783
GINOP
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Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM084868
Első szerző:Damjanovich Péter Gábor (szülész-nőgyógyász)
Cím:Cervicovaginal lavage fluid zinc level as a marker of vaginal atrophy / Damjanovich Peter, Sipos Attila Gergely, Larson Kindra, Cunningham Tina D., Takacs Peter, Kozma Bence
Dátum:2020
ISSN:1530-0374
Megjegyzések:Objectives: This study aimed to investigate the correlation between cervicovaginal fluid zinc levels and participants' menopausal status and the presence of vulvovaginal symptoms of genitourinary syndrome of menopause. Methods: Women included in the study underwent a pelvic examination, collection of vaginal cytology, and cervicovaginal lavage was performed in a standardized fashion. The cervicovaginal lavage zinc content was determined. The vaginal health index was calculated, and the visual analog scale was obtained based on the participant's burning, itching, vaginal pain, dyspareunia, dryness, and dysuria. Results: One hundred twenty women participated in the study. Eighty-two participants were menopausal. The mean vaginal health index was 15 ? 6, while the total visual analog scale score was 14 ? 14. We found significant differences between cervicovaginal lavage zinc level and age group, menopausal status, presence of vaginal dryness, and vaginal atrophy. We also found a moderate positive correlation between Vaginal Maturation Value and cervicovaginal lavage zinc levels (r = 0.495, P value < 0.01) in the correlation analysis. However, in the multivariate regression model, including all significant factors, only vaginal atrophy remained significant. Conclusions: We found a significant association between vaginal atrophy (vaginal maturation value < 50) and cervicovaginal lavage zinc levels. Zinc levels of cervicovaginal lavage could be used as a new marker of vaginal atrophy.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Menopause. - 27 : 7 (2020), p. 776-779. -
További szerzők:Sipos Attila Gergely (1990-) (szülész-nőgyógyász) Larson, Kindra Cunningham, Tina D. Takács Péter (1968-) (szülész-nőgyógyász) Kozma Bence (1982-) (szülész-nőgyógyász)
Pályázati támogatás:GINOP-2.1.1-15-2016-00783
GINOP
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Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM116872
035-os BibID:(WoS)001111426100001 (Scopus)85178231255
Első szerző:Koroknai Erzsébet (szülész-nőgyógyász)
Cím:Correlation between the female pelvic floor biomechanical parameters and the severity of stress urinary incontinence / Koroknai Erzsébet, Rátonyi Dávid, Pákozdy Krisztina, Sipos Attila G., Krasznai Zoárd, Takacs Peter, Kozma Bence
Dátum:2023
ISSN:1471-2490
Megjegyzések:Background: Stress urinary incontinence (SUI) is a common condition that requires proper evaluation to select a personalized therapy. Vaginal Tactile Imaging (VTI) is a novel method to assess the biomechanical parameters of the pelvic floor. Methods: Women with SUI were enrolled in this cross-sectional study. Participants completed the Medical, Epidemiologic, and Social Aspects of Aging (MESA) questionnaire and the Patient Global Impression of Severity Question (PGI-S) and underwent a VTI examination. Based on the MESA and PGI-S questionnaires, participants were divided into mild, moderate, and severe SUI groups. Fifty-two biomechanical parameters of the pelvic floor were measured by VTI and compared between the groups (mild vs. moderate and severe). SUI Score and Index were calculated from the MESA questionnaire. Pearson correlation was used to determine the strength of association between selected VTI parameters and the MESA SUI Index and MESA SUI Score. Results: Thirty-one women were enrolled into the study. Significant differences were observed in the VTI parameters 16, 22-24, 38, 39 when the difference between mild and severe subgroups of SUI based on the PGI-S score was examined. Parameter 16 refers to the maximum gradient at the perineal body, parameter 22-24 refers to the pressure response of the tissues behind the vaginal walls, and parameter 38, 39 refers the maximum pressure change and value on the right side at voluntary muscle contraction. VTI parameter 49, describing the displacement of the maximum pressure peak in the anterior compartment, showed a significant difference between the mild SUI and the moderate-severe SUI according to the MESA SUI score (mean ? SD 14.06?5.16 vs. 7.54?7.46, P=0.04). The MESA SUI Index and SUI Score displayed a positive correlation concerning VTI parameters 4 (the maximum value of the posterior gradient) and 27 (the displacement of the maximum pressure peak in the anterior compartment) (VTI4 vs. MESA SUI Index r=0.373,P=0.039; VTI4 vs. MESA SUI Score r=0.376,P=0.037; VTI27 vs. MESA SUI Index r=0.366,P=0.043; VTI27 vs. MESA SUI Score r=0.363,P=0.044). Conclusions: Female pelvic floor biomechanical parameters, as measured by VTI, correlate significantly with the severity of SUI and may help guide therapeutic decisions.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
stress urinary incontinence
pelvic floor
biomechanical parameters of the pelvic floor
questionnaires
disease severity
Megjelenés:BMC Urology. - 23 : 1 (2023), p. 198-204. -
További szerzők:Rátonyi Dávid (1996-) (Szülész-nőgyógyász) Pákozdy Krisztina (1991-) (szülész-nőgyógyász) Sipos Attila Gergely (1990-) (szülész-nőgyógyász) Krasznai Zoárd Tibor (1973-) (szülész-nőgyógyász, gyermeknőgyógyász) Takács Péter (1968-) (szülész-nőgyógyász) Kozma Bence (1982-) (szülész-nőgyógyász)
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6.

001-es BibID:BIBFORM104386
Első szerző:Kozma Bence (szülész-nőgyógyász)
Cím:Zinc-containing Vaginal Gel for the Prevention of Recurrent Vaginal Infections : a Pilot Trial / Kozma Bence, Sipos Attila Gergely, Pákozdy Krisztina, Takács Péter
Dátum:2022
ISSN:0937-3462
Megjegyzések:Introduction: Zinc deficiency is closely linked to impaired mucosal integrity which is critical for the prevention of infections. The presence of zinc in the epidermis promotes epidermal homeostasis. Oral supplementation with zinc had no significant impact on cervicovaginal lavage zinc level despite a significant rise in serum zinc level. However, vaginal application of zinc in the form of a zinc-containing vaginal gel is undoubtedly a viable option to deliver zinc to the vagina. Zinc transporters are present in the vagina and ZIP4 is present in the vagina wall for absorption of vaginal zinc replenishment. Objective: To test the hypothesis that prophylactic use of zinc containing vaginal gel decreases the reoccurrence rate of vaginal infection in women with a diagnosis of recurrent vaginal infections. Methods: Women with a history of recurrent vaginal infections (bacterial vaginosis or recurrent vulvovaginal candidiasis) were offered prophylactic treatment with a commercially available zinc-containing vaginal moisturizer gel. Women were asked to use the vaginal gel daily for two weeks and after that twice per week. Women were asked to return to the clinic if any symptoms of vaginal infection were present for evaluation. Results: Eight women were enrolled. The mean age was 32 ? 6 years, mean BMI 24 ? 5, Gravida 1.5 (0-3), Para 1.5 (0-3). All women were premenopausal. None of the patients were using any oral or vaginal hormonal treatment. The number of sexual partners was 1 (1-3). On average, there was at least one infection every three months before treatment. After treatment with the zinc-containing vaginal gel, 5 out 8 women did not have an infection in the first three months (P=0.04). Three women developed one vaginal infection resulting in a 62% reduction in infections. Conclusions: Zinc-containing vaginal gel may help to prevent recurrent vaginal infections. Further studies are required to delineate the possible mechanism of action: zinc - immunoprotective -immunomodulation through vaginal dendritic cells / Langerhans cells; lactic acid ? acidic pH favors lactobacilli and prevents overgrowth of other organisms; hydroxyethyl cellulose - gentle exfoliation - increased availability of glycogen, favors lactobacilli growth.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:International Urogynecology Journal. - 33 : Suppl. 2 (2022), p. S402. -
További szerzők:Sipos Attila Gergely (1990-) (szülész-nőgyógyász) Pákozdy Krisztina (1991-) (szülész-nőgyógyász) Takács Péter (1968-) (szülész-nőgyógyász)
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Intézményi repozitóriumban (DEA) tárolt változat
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7.

001-es BibID:BIBFORM094906
Első szerző:Kozma Bence (szülész-nőgyógyász)
Cím:Vaginal elasticity is significantly decreased in vaginal atrophy : a strain elastography study / Kozma Bence, Damjanovich Péter, Pákozdy Krisztina, Sipos Attila Gergely, Bombicz Mariann, Takács Péter
Dátum:2021
ISSN:0937-3462
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:International Urogynecology Journal. - 31 : Suppl1 (2021), p. S33-S34. -
További szerzők:Damjanovich Péter Gábor (1985-) (szülész-nőgyógyász) Pákozdy Krisztina (1991-) (szülész-nőgyógyász) Sipos Attila Gergely (1990-) (szülész-nőgyógyász) Bombicz Mariann (1987-) (gyógyszerész) Takács Péter (1968-) (szülész-nőgyógyász)
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Intézményi repozitóriumban (DEA) tárolt változat
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8.

001-es BibID:BIBFORM093935
035-os BibID:(WoS)000646274200001 (Scopus)85105275337
Első szerző:Kozma Bence (szülész-nőgyógyász)
Cím:Ultrahang-elasztográfia alkalmazásának lehetőségei a szülészet-nőgyógyászatban / Kozma Bence, Pákozdy Krisztina, Lampé Rudolf, Berényi Ervin, Takács Péter
Dátum:2021
ISSN:0030-6002 1788-6120
Megjegyzések:Az ultrahang-elasztográfia az elmúlt évek során egyre növekvő figyelmet kapott a lágyszövetek elaszticitásának vizsgálatában. A módszer használatát az teszi szükségessé, hogy egyes, a mechanikai tulajdonságaikban különböző szövetek hasonló echogenitásúak lehetnek, valamint hogy egy adott szövet megváltozott struktúrája vagy mechanikai tulajdonsága nem minden esetben jár együtt a szövet hagyományos ultrahangképének megváltozásával. Az elmúlt évtizedben a deformációs és a nyírási ultrahang-elasztográfia vált széles körben elérhetővé. Ezen új képalkotási technika egyre nagyobb szerepet tölt be a szülészeti-nőgyógyászati ultrahang-diagnosztikában is. A nőgyógyászatban szerephez juthat az endometriosis és az adenomyosis kimutatásában, valamint a benignus és a malignus cervicalis és ovarialis képletek elkülönítésében. A nőgyógyászathoz hasonlóan a szülészetben is jelentős változást hozhat az ultrahang-elasztográfia: alkalmas lehet a szülésindukció sikerességének, a koraszülés bekövetkezésének és a praeeclampsia kialakulásának előrejelzésére.
Tárgyszavak:Orvostudományok Klinikai orvostudományok magyar nyelvű folyóiratközlemény hazai lapban
folyóiratcikk
ultrahang-elasztográfia
deformációs elasztográfia
nyírási elasztográfia
szöveti keménység
Megjelenés:Orvosi Hetilap. - 162 : 18 (2021), p. 690-695. -
További szerzők:Pákozdy Krisztina (1991-) (szülész-nőgyógyász) Lampé Rudolf (1983-) (szülész-nőgyógyász) Berényi Ervin (1964-) (radiológus) Takács Péter (1968-) (szülész-nőgyógyász)
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Intézményi repozitóriumban (DEA) tárolt változat
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9.

001-es BibID:BIBFORM084850
Első szerző:Kozma Bence (szülész-nőgyógyász)
Cím:Association between pelvic organ prolapse types and levator-urethra gap as measured by 3D transperineal ultrasound / Kozma Bence, Larson Kindra, Scott Lauren, Cunningham Tina, Abuhamad Alfred, Póka Róbert, Takacs Péter
Dátum:2018
ISSN:0937-3462
Megjegyzések:Introduction: Pelvic organ prolapse (POP) is a common condition affecting many women. During delivery, the components of the levator ani muscle undergo significant distention and stretching leading to muscle damage 10-25% of the time. Injury to the pelvic floor muscles can result in floor dysfunction like POP or stress urinary incontinence. Levator ani defects can be diagnosed clinically by vaginal palpation or using transperineal ultrasound. Previously the standard sonographic diagnosis of levator avulsion required observation of an abnormal insertion of the muscle on tomographic ultrasound imaging (TUI). But most recently the measurement of the levator?urethra gap (LUG) has been described as a quantitative tool in this regard. LUG is the distance between the center of the urethral lumen and insertion of the levator on the inferior pubic ramus, determined bilaterally, in axial slices on transperineal 3D ultrasound. The measurement of LUG is reproducible and an abnormal LUG (?25mm) has been strongly associated with avulsion diagnosed by vaginal palpation. Objectives: To evaluate the association between POP types and LUG as measured by 3D transperineal tomographic ultrasound (TPUS). Methods: A retrospective study was carried out on ninety-eight women with symptomatic POP. 3D TPUS images and Pelvic Organ Prolapse Quantification coordinates were reviewed. Each vaginal compartment was staged for the degree of prolapse, and total number of involved compartments identified. LUG was measured on 3D tomographic ultrasound images as the distance between the center of the urethra and the levator insertion bilaterally. Based upon prior studies, an abnormal LUG?25mm indicated levator avulsion. LUG and presence or absence of unilateral/bilateral avulsions was analyzed with reference to the clinical diagnosis of prolapse [single vs. multi compartment, and mild (stage II) vs. severe (stage III-IV)]. Generalized logit models were used to evaluate the association between avulsion and prolapse type and stage. Results: The LUG was significantly larger in women with multi compartment compared to single compartment POP (28.9?4.1mm vs. 22.7 ?4.1mm, P<0.01). Similarly, LUG was significantly larger in women with severe (stage III-IV) compared to mild POP (stage II) (28.8 ?4.7mm vs. 23.3?4.5mm, P<0.01). Women with severe prolapse were 32 times more likely than women with mild prolapse to have bilateral levator avulsion. Those with POP involving all three vaginal compartments were 76 times more likely than single compartment POP to have bilateral levator avulsions. Conclusions: Bilateral levator ani avulsion as diagnosed by LUG measurements of ?25mm at rest is associated with multi compartment, sever prolapse.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:International Urogynecology Journal. - 29 : S1 (2018), p. 174. -
További szerzők:Larson, Kindra Scott, Lauren Cunningham, Tina D. Abuhamad, Alfred Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus) Takács Péter (1968-) (szülész-nőgyógyász)
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Intézményi repozitóriumban (DEA) tárolt változat
Borító:

10.

001-es BibID:BIBFORM084851
Első szerző:Kozma Bence (szülész-nőgyógyász)
Cím:Fractional CO2 laser treatment significantly increases vaginal fluid zinc and copper level / Kozma Bence, Takács Péter, Póka Róbert
Dátum:2018
ISSN:0937-3462
Megjegyzések:Introduction: Fractional CO2 laser treatment became a popular treatment option for postmenopausal vaginal atrophy. The laser therapy creates microinjuries of the vagina and subsequent remodeling leads to the reorganization of the extracellular matrix of the vagina. Zinc and copper are essential trace elements and both play a vital role in tissue remodeling. Both zinc and copper functions as a cofactor for many enzymes participating in the composition of the extracellular matrix. Objectives: To evaluate the effect of the Mona Lisa Touch CO2 laser treatment on postmenopausal women vaginal fluid trace element content: zinc and copper. Both zinc and copper play a pivotal role as a cofactor for several enzymes responsible for tissue remodeling. Our hypothesis was that increased tissue remodeling secondary to vaginal laser treatment will result in altered vaginal fluid zinc and copper content. Materials and Methods: Twenty-seven postmenopausal women with genitourinary symptoms of menopause were enrolled and underwent vaginal laser treatment. Mona Lisa Touch is a functional vaginal rejuvenation treatment based on a special fractional CO2 laser, specifically created for the vaginal mucosa. Patients received three vaginal laser treatments with the 360 degree probe 4-6 weeks apart. Vaginal fluid was collected in a standardized fashion. Extreme care was exercised to avoid any possible contamination. Only single use plastic speculums free of trace elements were used. Atomic absorption spectroscopy was used to determine the vaginal fluid zinc and copper content. Paired t-test was used to compare the before and after treatment results. Results: All patients were in menopause. The average age was 58 ? 9 years. The mean zinc level was 0.08 ? 0.08 mg/L before the initiation of the first treatment. After the first treatment the vaginal zinc level did not change significantly (0.08 ? 0.05 mg/L) But after the second laser treatment vaginal fluid zinc level was significantly higher 0.11 ? 0.07 mg/L (P< 0.01) and the third treatment increased vagina zinc levels even further to 0.16 ? 0.08 mg/L (P<0.01). The mean copper level was 0.008 ? 0.009 mg/L before the initiation of the first treatment. After the first and second treatment the vaginal copper level did not change significantly (0.010 ? 0.011 mg/L and 0.009 ? 0.008) But after the third laser treatment vaginal fluid copper level was significantly higher 0.016 ? 0.014 mg/L (P=0.04). Zinc content of the vaginal fluid was ten folds higher than copper levels. Conclusion: Microablative fractional CO2 vaginal laser treatment significantly increases vaginal fluid zinc content. Zinc and copper levels increased by two folds after the third laser treatment. Elevated zinc and copper levels in the vaginal fluid is most likely occurs secondary to the increased vaginal remodeling.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:International Urogynecology Journal. - 29 : S1 (2018), p. 174-175. -
További szerzők:Takács Péter (1968-) (szülész-nőgyógyász) Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus)
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Intézményi repozitóriumban (DEA) tárolt változat
Borító:

11.

001-es BibID:BIBFORM084853
Első szerző:Kozma Bence (szülész-nőgyógyász)
Cím:The effects of fractional CO2 laser treatment on the symptoms of pelvic floor dysfunctions and vulvovaginal atrophy / Kozma Bence, Takács Péter, Sipos Attila Gergely, Póka Róbert
Dátum:2018
ISSN:0937-3462
Megjegyzések:Introduction: Vaginal laser treatment became a popular treatment modality for genitourinary syndrome of menopause. However scientific data is limited regarding the effects of laser treatment on different pelvic floor dysfunctions. Objectives: To evaluate the effect of the Mona Lisa Touch CO2 laser treatment on postmenopausal women vulvovaginal and pelvic floor dysfunction symptoms. Methods: Forty-three postmenopausal women were enrolled and underwent vaginal laser treatment with. Mona Lisa Touch. Patients received three vaginal laser treatments with the 360 degree probe 4-6 weeks apart. Pelvic Organ Prolapse Distress Inventory 6 (POPDI-6), Colorectal?Anal Distress Inventory 8 (CRADI-8) and Urinary Distress Inventory 6 (UDI-6) validated questionnaires were filled out by each patient before each session and 4 weeks after the final treatment. Vaginal Health Index (Elasticity, Fluid Secretion, pH, Epithelial mucosa, Moisture) was calculated before each session and 4 weeks after the final treatment. In addition, patients were asked to fill out a Visual Analog Scale (1-10, lower scores indicates less bother) on vaginal pain, dryness, burning, itching, dyspareunia and dysuria. Paired ttest was used to compare the before and after treatment results. Results: All patients were in menopause. The average age was 57?10 years. POPD-6 standardized scores were not significantly different after the first treatment (20 ?19 vs. 14?11 after the first treatment). But after the second treatment there was a significant improvement in the standardized score to 11?12 ( P=0.02). After the third treatment the score was even lower 10?13 (P=0.01). CRADI-8 standardized scores did not change significantly after three laser treatment (16 ?18 vs. 13?17 after the 1st treatment/13?16 after the 2nd treatment/ 12?18 after the 3rd treatment). UDI-6 standardized scores were not significantly different after the first laser treatment (32?23 vs. 26?23 after the first treatment). But after the second treatment there was a significant improvement in the standardized score to 25 ? 20 ( P=0.03). The Vaginal Health Index was 15?5 before and 17?4 after the first treatment, 19?5 after the second and 21?4 after the third treatment. VHI was significantly improved after each treatment (P<0.01). The largest incremental change occurred in vaginal moisture, followed by vaginal fluid and elasticity. The patient reported combined Visual Analog Score (VAS) was 16?16 before and 9?12 after the first treatment, 6 ? 9 after the second and 3 ? 8 after the third treatment. VAS was significantly lower (P<0.01) after each laser treatment. The largest improvement occurred after the first laser treatment, but each additional treatment added additional symptoms relief. Conclusion: CO2 vaginal laser treatment significantly improves patient reported urinary and pelvic organ prolapse bother. The minimum of two laser treatments were needed to achieve a significant benefit. In addition, CO2 vaginal laser treatment significantly improves both the patient reported subjective symptoms and the Vaginal Health Index in postmenopausal women even after a single laser treatment.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:International Urogynecology Journal. - 29 : S1 (2018), p. 174. -
További szerzők:Takács Péter (1968-) (szülész-nőgyógyász) Sipos Attila Gergely (1990-) (szülész-nőgyógyász) Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus)
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12.

001-es BibID:BIBFORM081140
035-os BibID:(scopus)85072931858 (wos)000489109700002
Első szerző:Kozma Bence (szülész-nőgyógyász)
Cím:A hüvelyi CO2-lézer-kezelés rövid távú hatásai a menopausalis genitourinalis szindróma tüneteire / Kozma Bence, Póka Róbert, Sipos Attila, Ács Nándor, Takács Péter
Dátum:2019
ISSN:0030-6002 1788-6120
Tárgyszavak:Orvostudományok Klinikai orvostudományok magyar nyelvű folyóiratközlemény hazai lapban
folyóiratcikk
Megjelenés:Orvosi Hetilap. - 160 : 41 (2019), p. 1617-1622. -
További szerzők:Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus) Sipos Attila Gergely (1990-) (szülész-nőgyógyász) Ács Nándor Takács Péter (1968-) (szülész-nőgyógyász)
Pályázati támogatás:GINOP-2.1.1-15-2016-00783
GINOP
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