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1.

001-es BibID:BIBFORM084868
Első szerző:Damjanovich Péter Gábor (szülész-nőgyógyász)
Cím:Cervicovaginal lavage fluid zinc level as a marker of vaginal atrophy / Damjanovich Peter, Sipos Attila Gergely, Larson Kindra, Cunningham Tina D., Takacs Peter, Kozma Bence
Dátum:2020
ISSN:1530-0374
Megjegyzések:Objectives: This study aimed to investigate the correlation between cervicovaginal fluid zinc levels and participants' menopausal status and the presence of vulvovaginal symptoms of genitourinary syndrome of menopause. Methods: Women included in the study underwent a pelvic examination, collection of vaginal cytology, and cervicovaginal lavage was performed in a standardized fashion. The cervicovaginal lavage zinc content was determined. The vaginal health index was calculated, and the visual analog scale was obtained based on the participant's burning, itching, vaginal pain, dyspareunia, dryness, and dysuria. Results: One hundred twenty women participated in the study. Eighty-two participants were menopausal. The mean vaginal health index was 15 ? 6, while the total visual analog scale score was 14 ? 14. We found significant differences between cervicovaginal lavage zinc level and age group, menopausal status, presence of vaginal dryness, and vaginal atrophy. We also found a moderate positive correlation between Vaginal Maturation Value and cervicovaginal lavage zinc levels (r = 0.495, P value < 0.01) in the correlation analysis. However, in the multivariate regression model, including all significant factors, only vaginal atrophy remained significant. Conclusions: We found a significant association between vaginal atrophy (vaginal maturation value < 50) and cervicovaginal lavage zinc levels. Zinc levels of cervicovaginal lavage could be used as a new marker of vaginal atrophy.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Menopause. - 27 : 7 (2020), p. 776-779. -
További szerzők:Sipos Attila Gergely (1990-) (szülész-nőgyógyász) Larson, Kindra Cunningham, Tina D. Takács Péter (1968-) (szülész-nőgyógyász) Kozma Bence (1982-) (szülész-nőgyógyász)
Pályázati támogatás:GINOP-2.1.1-15-2016-00783
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2.

001-es BibID:BIBFORM104386
Első szerző:Kozma Bence (szülész-nőgyógyász)
Cím:Zinc-containing Vaginal Gel for the Prevention of Recurrent Vaginal Infections : a Pilot Trial / Kozma Bence, Sipos Attila Gergely, Pákozdy Krisztina, Takács Péter
Dátum:2022
ISSN:0937-3462
Megjegyzések:Introduction: Zinc deficiency is closely linked to impaired mucosal integrity which is critical for the prevention of infections. The presence of zinc in the epidermis promotes epidermal homeostasis. Oral supplementation with zinc had no significant impact on cervicovaginal lavage zinc level despite a significant rise in serum zinc level. However, vaginal application of zinc in the form of a zinc-containing vaginal gel is undoubtedly a viable option to deliver zinc to the vagina. Zinc transporters are present in the vagina and ZIP4 is present in the vagina wall for absorption of vaginal zinc replenishment. Objective: To test the hypothesis that prophylactic use of zinc containing vaginal gel decreases the reoccurrence rate of vaginal infection in women with a diagnosis of recurrent vaginal infections. Methods: Women with a history of recurrent vaginal infections (bacterial vaginosis or recurrent vulvovaginal candidiasis) were offered prophylactic treatment with a commercially available zinc-containing vaginal moisturizer gel. Women were asked to use the vaginal gel daily for two weeks and after that twice per week. Women were asked to return to the clinic if any symptoms of vaginal infection were present for evaluation. Results: Eight women were enrolled. The mean age was 32 ? 6 years, mean BMI 24 ? 5, Gravida 1.5 (0-3), Para 1.5 (0-3). All women were premenopausal. None of the patients were using any oral or vaginal hormonal treatment. The number of sexual partners was 1 (1-3). On average, there was at least one infection every three months before treatment. After treatment with the zinc-containing vaginal gel, 5 out 8 women did not have an infection in the first three months (P=0.04). Three women developed one vaginal infection resulting in a 62% reduction in infections. Conclusions: Zinc-containing vaginal gel may help to prevent recurrent vaginal infections. Further studies are required to delineate the possible mechanism of action: zinc - immunoprotective -immunomodulation through vaginal dendritic cells / Langerhans cells; lactic acid ? acidic pH favors lactobacilli and prevents overgrowth of other organisms; hydroxyethyl cellulose - gentle exfoliation - increased availability of glycogen, favors lactobacilli growth.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:International Urogynecology Journal. - 33 : Suppl. 2 (2022), p. S402. -
További szerzők:Sipos Attila Gergely (1990-) (szülész-nőgyógyász) Pákozdy Krisztina (1991-) (szülész-nőgyógyász) Takács Péter (1968-) (szülész-nőgyógyász)
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3.

001-es BibID:BIBFORM094906
Első szerző:Kozma Bence (szülész-nőgyógyász)
Cím:Vaginal elasticity is significantly decreased in vaginal atrophy : a strain elastography study / Kozma Bence, Damjanovich Péter, Pákozdy Krisztina, Sipos Attila Gergely, Bombicz Mariann, Takács Péter
Dátum:2021
ISSN:0937-3462
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:International Urogynecology Journal. - 31 : Suppl1 (2021), p. S33-S34. -
További szerzők:Damjanovich Péter Gábor (1985-) (szülész-nőgyógyász) Pákozdy Krisztina (1991-) (szülész-nőgyógyász) Sipos Attila Gergely (1990-) (szülész-nőgyógyász) Bombicz Mariann (1987-) (gyógyszerész) Takács Péter (1968-) (szülész-nőgyógyász)
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Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM084853
Első szerző:Kozma Bence (szülész-nőgyógyász)
Cím:The effects of fractional CO2 laser treatment on the symptoms of pelvic floor dysfunctions and vulvovaginal atrophy / Kozma Bence, Takács Péter, Sipos Attila Gergely, Póka Róbert
Dátum:2018
ISSN:0937-3462
Megjegyzések:Introduction: Vaginal laser treatment became a popular treatment modality for genitourinary syndrome of menopause. However scientific data is limited regarding the effects of laser treatment on different pelvic floor dysfunctions. Objectives: To evaluate the effect of the Mona Lisa Touch CO2 laser treatment on postmenopausal women vulvovaginal and pelvic floor dysfunction symptoms. Methods: Forty-three postmenopausal women were enrolled and underwent vaginal laser treatment with. Mona Lisa Touch. Patients received three vaginal laser treatments with the 360 degree probe 4-6 weeks apart. Pelvic Organ Prolapse Distress Inventory 6 (POPDI-6), Colorectal?Anal Distress Inventory 8 (CRADI-8) and Urinary Distress Inventory 6 (UDI-6) validated questionnaires were filled out by each patient before each session and 4 weeks after the final treatment. Vaginal Health Index (Elasticity, Fluid Secretion, pH, Epithelial mucosa, Moisture) was calculated before each session and 4 weeks after the final treatment. In addition, patients were asked to fill out a Visual Analog Scale (1-10, lower scores indicates less bother) on vaginal pain, dryness, burning, itching, dyspareunia and dysuria. Paired ttest was used to compare the before and after treatment results. Results: All patients were in menopause. The average age was 57?10 years. POPD-6 standardized scores were not significantly different after the first treatment (20 ?19 vs. 14?11 after the first treatment). But after the second treatment there was a significant improvement in the standardized score to 11?12 ( P=0.02). After the third treatment the score was even lower 10?13 (P=0.01). CRADI-8 standardized scores did not change significantly after three laser treatment (16 ?18 vs. 13?17 after the 1st treatment/13?16 after the 2nd treatment/ 12?18 after the 3rd treatment). UDI-6 standardized scores were not significantly different after the first laser treatment (32?23 vs. 26?23 after the first treatment). But after the second treatment there was a significant improvement in the standardized score to 25 ? 20 ( P=0.03). The Vaginal Health Index was 15?5 before and 17?4 after the first treatment, 19?5 after the second and 21?4 after the third treatment. VHI was significantly improved after each treatment (P<0.01). The largest incremental change occurred in vaginal moisture, followed by vaginal fluid and elasticity. The patient reported combined Visual Analog Score (VAS) was 16?16 before and 9?12 after the first treatment, 6 ? 9 after the second and 3 ? 8 after the third treatment. VAS was significantly lower (P<0.01) after each laser treatment. The largest improvement occurred after the first laser treatment, but each additional treatment added additional symptoms relief. Conclusion: CO2 vaginal laser treatment significantly improves patient reported urinary and pelvic organ prolapse bother. The minimum of two laser treatments were needed to achieve a significant benefit. In addition, CO2 vaginal laser treatment significantly improves both the patient reported subjective symptoms and the Vaginal Health Index in postmenopausal women even after a single laser treatment.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:International Urogynecology Journal. - 29 : S1 (2018), p. 174. -
További szerzők:Takács Péter (1968-) (szülész-nőgyógyász) Sipos Attila Gergely (1990-) (szülész-nőgyógyász) Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus)
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Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM081140
035-os BibID:(scopus)85072931858 (wos)000489109700002
Első szerző:Kozma Bence (szülész-nőgyógyász)
Cím:A hüvelyi CO2-lézer-kezelés rövid távú hatásai a menopausalis genitourinalis szindróma tüneteire / Kozma Bence, Póka Róbert, Sipos Attila, Ács Nándor, Takács Péter
Dátum:2019
ISSN:0030-6002 1788-6120
Tárgyszavak:Orvostudományok Klinikai orvostudományok magyar nyelvű folyóiratközlemény hazai lapban
folyóiratcikk
Megjelenés:Orvosi Hetilap. - 160 : 41 (2019), p. 1617-1622. -
További szerzők:Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus) Sipos Attila Gergely (1990-) (szülész-nőgyógyász) Ács Nándor Takács Péter (1968-) (szülész-nőgyógyász)
Pályázati támogatás:GINOP-2.1.1-15-2016-00783
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Intézményi repozitóriumban (DEA) tárolt változat
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6.

001-es BibID:BIBFORM089120
Első szerző:Pákozdy Krisztina (szülész-nőgyógyász)
Cím:Vaginal elasticity is significantly decreased in vaginal atrophy / Pákozdy Krisztina, Sipos Attila G., Bombicz Mariann, Lampé Rudolf, Póka Róbert, Takacs Peter, Kozma Bence
Dátum:2020
ISSN:1530-0374
Megjegyzések:taa, km
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Elastography
Vulvovaginal atrophy
Vaginal wall
Vaginal cytology
Transvaginal ultrasound
Genitourinary syndrome of menopause
Megjelenés:Menopause. - 27 : 12 (2020), p. 1420-1424. -
További szerzők:Sipos Attila Gergely (1990-) (szülész-nőgyógyász) Bombicz Mariann (1987-) (gyógyszerész) Lampé Rudolf (1983-) (szülész-nőgyógyász) Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus) Takács Péter (1968-) (szülész-nőgyógyász) Kozma Bence (1982-) (szülész-nőgyógyász)
Pályázati támogatás:GINOP-2.1.1-15-2016-00783
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Intézményi repozitóriumban (DEA) tárolt változat
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7.

001-es BibID:BIBFORM094864
Első szerző:Sipos Attila Gergely (szülész-nőgyógyász)
Cím:Fractional CO2 laser treatment effect on cervicovaginal lavage zinc and copper levels : a prospective cohort study / Attila G. Sipos, Krisztina Pákozdy, Szilvia Jäger, Kindra Larson, Peter Takacs, Bence Kozma
Dátum:2021
ISSN:1472-6874
Megjegyzések:Background: The basic principle of vaginal laser therapy is the rejuvenation of the affected tissue. Zinc and copper are essential nutritional trace elements and have a key role in connective tissue homeostasis. We aimed to investigate the effect of vaginal, fractional CO2 laser treatment on cervicovaginal lavage (CVL) zinc and copper levels. Methods: Twenty-nine postmenopausal women with symptoms of vaginal dryness were enrolled in our prospec-tive cohort study. Three treatments with MonaLisa Touch CO2 laser system were performed four weeks apart. At each treatment CVL was collected, Vaginal Health Index (VHI) was obtained, and Visual Analog Scale (VAS) for vaginal dry-ness was assigned by patients. Zinc and copper concentrations were measured with optical emission spectrometry before each treatment and six weeks after the 3rd treatment. Results: The VHI scores significantly improved after each laser treatment (mean ?SD VHI score, 13.03 ? 4.49 before vs. 15.55 ?4.35 after the 1st, 17.79 ?4.57 after the 2nd and 19.38 ?4.39 after the 3rd treatment, P < 0.01). Similarly, VAS scores reflected improvement (mean ?SD VAS score 6.59 ?2.86 before vs. 4.17 ?2.86 after the 1st, 2.45 ? 2.43 after the 2nd and 1.41 ?1.94 after the 3rd treatment, P < 0.01). CVL zinc levels were significantly higher compared to copper levels (0.06 ?0.04 vs. 0.006 ?0.006 mg/L, P < 0.01) at baseline. While copper levels remained the same through treatments, the CVL zinc level was significantly higher after the second laser treatment compared to the baseline. Conclusions: Fractional CO2 laser treatment of the vagina impacts CVL zinc and copper levels differently. While CVL copper levels were not different after each laser treatment, zinc levels were significantly higher after the second treat-ment before returning to baseline values.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
CO2 laser
Fractional laser
Vagina
Zinc
Copper
Cervicovaginal fluid
Megjelenés:BMC Womens Health. - 21 : 1 (2021), p. 235. -
További szerzők:Pákozdy Krisztina (1991-) (szülész-nőgyógyász) Jäger Szilvia (1974-) (biokémikus) Larson, Kindra Takács Péter (1968-) (szülész-nőgyógyász) Kozma Bence (1982-) (szülész-nőgyógyász)
Pályázati támogatás:GINOP-2.1.1-15-2016-00783
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Intézményi repozitóriumban (DEA) tárolt változat
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8.

001-es BibID:BIBFORM081242
Első szerző:Sipos Attila Gergely (szülész-nőgyógyász)
Cím:The Effect of Fractional CO2 Laser Treatment on the Symptoms of Pelvic Floor Dysfunctions : pelvic Floor Distress Inventory-20 Questionnaire / Attila Gergely Sipos, Bence Kozma, Robert Poka, Kindra Larson, Peter Takacs
Dátum:2019
ISSN:0196-8092
Megjegyzések:Background and Objectives: To assess the improve- ment on pelvic floor distress (PFD)?related urogenital symptoms using validated questionnaires after intrava- ginal CO 2 laser treatment. Study Design/Materials and Methods: Forty postme- nopausal women with genitourinary symptoms of menopause (GSM) were enrolled into this prospective cohort study and underwent vaginal laser treatment using MonaLisa Touch ? fractional CO 2 laser system. Patients received three vaginal laser treatments with 360? probe 4 weeks apart. A three?component Pelvic Floor Distress Inventory (PFDI?20) validated question- naire was filled out by each patient before each session and 4 weeks after the final treatment. Wilcoxon rank sum test was used to compare the before and after treatment scores. Results: Pelvic Organ Prolapse Distress Inventory (POPDI?6) scores were not significantly different after the first treatment compared with baseline (mean ? standard deviation [SD], 21 ? 18 vs. 17 ? 15, P = 0.44). However, each subsequent treatment resulted in further, statistically significant improvement in symp- tom scores (14 ? 15, P = 0.03 and 13 ? 13, P = 0.01, after the second and third treatments, respectively). Simi- larly, Urinary Distress Inventory (UDI?6) scores were not significantly different after the first laser treat- ment (mean ? SD, 36 ? 25 vs. 29 ? 23, P = 0.36). After the second and third treatments there were significant improvement in the standardized scores (24 ? 20, P = 0.03 and 22 ? 21, P = 0.01). Colorectal?Anal Dis- tress Inventory (CRADI?8) scores did not change significantly after three laser treatments. Conclusions: Three sessions of microablative fractional CO 2 vaginal laser treatment significantly improves patient reported urinary and pelvic organ prolapse symptoms.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Lasers In Surgery And Medicine. - 51 : 10 (2019), p. 882-886. -
További szerzők:Kozma Bence (1982-) (szülész-nőgyógyász) Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus) Larson, Kindra Takács Péter (1968-) (szülész-nőgyógyász)
Pályázati támogatás:GINOP-2.1.1-15-2016-00783
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9.

001-es BibID:BIBFORM085762
Első szerző:Takács Péter (szülész-nőgyógyász)
Cím:Randomized controlled trial for improved recovery of the pelvic floor after vaginal delivery with a specially formulated postpartum supplement / Takacs Peter, Kozma Bence, Lampé Rudolf, Sipos Attila, Poka Robert
Dátum:2020
ISSN:2287-8572 2287-8580
Megjegyzések:Objective To improve pelvic floor recovery after vaginal delivery with daily supplementation of a specially formulated postpartum recovery supplement. Methods Within 48 hours of vaginal delivery, primipara women were randomized in a 1:1 ratio to receive daily oral supplementation for 6 weeks with either a combination of regular prenatal vitamin (PNV), leucine (4 g/day), zinc (30 mg/day) and omega-3 fatty acid (900 mg/day) (treatment group), or only a PNV daily (control group). Co-primary outcomes were vaginal squeeze pressure as measured by perineometer and levator muscle injury as measured by transperineal 3-dimensional tomographic ultrasound at 6 weeks postpartum. Results Twenty-six women in the control group and 27 in the treatment group completed the trial. Weak pelvic floor muscle strength was significantly less frequent in the treatment group compared to the control group at 6 weeks after delivery (28% vs. 58%, P=0.03). Both right and left-sided levator-urethra gap was significantly larger in the control group compared to the treatment group indicating more levator injury being present in the control group at 6 weeks after delivery. Anterior vaginal wall prolapse at or beyond the hymenal ring was significantly more common in the control group compared to the treatment group (19% vs. 0%, P=0.02). Significantly more women reported bothersome bulge symptoms in the control group compared to the treatment group at 6 weeks postpartum (19% vs. 0%, P=0.02). Conclusion Postpartum women who received a specially formulated postpartum recovery supplement had improved recovery of the pelvic floor after vaginal delivery.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Postpartum
Pelvic floor
Omega-3 fatty acids
Zinc
Leucine
Megjelenés:Obstetrics & Gynecology Science. - 63 : 3 (2020), p. 305-314. -
További szerzők:Kozma Bence (1982-) (szülész-nőgyógyász) Lampé Rudolf (1983-) (szülész-nőgyógyász) Sipos Attila Gergely (1990-) (szülész-nőgyógyász) Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus)
Pályázati támogatás:GINOP-2.1.1-15-2016-00783
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Intézményi repozitóriumban (DEA) tárolt változat
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10.

001-es BibID:BIBFORM084241
Első szerző:Takács Péter (szülész-nőgyógyász)
Cím:The effect of oral zinc supplementation on cervicovaginal lavage fluid zinc level / Takacs Peter, Damjanovich Peter, Sipos Attila Gergely, Kozma Bence
Dátum:2020
ISSN:0301-2115
Megjegyzések:Objectives: To investigate the effect of oral zinc supplementation on cervicovaginal lavage fluid (CVL) zinc level in pre and postmenopausal women. Study design: A prospective interventional cohort study was carried out by the enrollment of twelve premenopausal and ten postmenopausal women without significant gynecological conditions. Women received daily oral supplementation with 30?mg of zinc for two weeks. Clinical and demographic variables were stored in a dedicated database. Vaginal Health Index was calculated, and vaginal cytology was obtained. CVL and serum samples were collected in a standardized fashion before and after completion of the oral supplementation. Zinc and copper levels were measured by inductively coupled plasma optical emission spectrometry. Paired t-test was used to compare the before and after treatment results. Results: Serum zinc levels increased significantly both in the pre and postmenopausal women (0.88???0.17 vs. 1.06???0.23, p?<?0.01 and 0.83???0.24 vs. 0.96???0.33, p?<?0.01) after two weeks of daily oral zinc supplementation. CVL zinc level was significantly higher in the premenopausal group compared to the postmenopausal group before and after supplementation (0.13???0.05 vs. 0.06???0.04, p?<?0.01 and 0.10???0.03 vs. 0.05???0.01, p?<?0.01). Zinc supplementation had no significant impact on the CVL zinc level in either group. Neither serum nor CVL copper levels were affected by the zinc supplementation. There was no significant correlation between serum and CVL zinc or copper levels. Conclusion: Daily oral supplementation with 30?mg of zinc had no significant impact on CVL zinc level despite a significant rise in serum zinc level.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Zinc
Cooper
Cervicovaginal lavage
Vaginal Health Index
Maturation value
Megjelenés:European Journal Of Obstetrics Gynecology And Reproductive Biology. - 248 (2020), p. 106-109. -
További szerzők:Damjanovich Péter Gábor (1985-) (szülész-nőgyógyász) Sipos Attila Gergely (1990-) (szülész-nőgyógyász) Kozma Bence (1982-) (szülész-nőgyógyász)
Pályázati támogatás:GINOP-2.1.1-15-2016-00783
GINOP
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Intézményi repozitóriumban (DEA) tárolt változat
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11.

001-es BibID:BIBFORM082801
Első szerző:Takács Péter (szülész-nőgyógyász)
Cím:The Effect of Vaginal Microablative Fractional CO2 Laser Treatment on Vaginal Cytology / Takacs Peter, Sipos Attila Gergely, Kozma Bence, Cunningham Tina D., Larson Kindra, Lampé Rudolf, Poka Robert
Dátum:2020
ISSN:0196-8092
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Lasers In Surgery And Medicine. - 52 : 8 (2020), p. 708-712. -
További szerzők:Sipos Attila Gergely (1990-) (szülész-nőgyógyász) Kozma Bence (1982-) (szülész-nőgyógyász) Cunningham, Tina D. Larson, Kindra Lampé Rudolf (1983-) (szülész-nőgyógyász) Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus)
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