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001-es BibID:BIBFORM068585
Első szerző:Illyés Tünde Zita (kémia-fizika szakos tanár)
Cím:Exploring the Syntheses of Novel Glycomimetics : Carbohydrate Derivatives with Se-S- or Se-Se- Glycosidic Linkages / Tünde-Zita Illyés, Sára Balla, Attila Bényei, Ambati Ashok Kumar, István Timári, Katalin E. Kövér, László Szilágyi
Dátum:2016
ISSN:2365-6549
Megjegyzések:A convenient route to Se-S-glycoside derivatives was developed using glycosyl isoselenuronium salts as glycosylselenenyl transfer reagents toward thiols. Aliphatic and aromatic thiols were found to react in the presence of N,N-diisopropylethylamine as a base and furnished alkyl- or aryl glycosylselenenylsulfide derivatives. S-glycosylselenenyl-cysteines were obtained similarly via reactions with O,N-protected cysteine. Reactions with monosaccharide thiols provided disaccharide mimics featuring Se-S- interglycosidic bonds. Further disaccharide mimics with Se-Se interglycosidic linkage were obtained from the starting isoselenuronium salts via reactions with protected monosaccharide derivatives bearing selenol groups in 6- or 4-position. The novel glycomimetics are expected to open new perspectives in biological activities and/or mechanistic studies due, i.a., to the rather uncommon Se-S- or Se-Se bonds incorporated into a carbohydrate framework.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Carbohydrate
selenosugar
selenenylsulfide
Se-Se-bond
Megjelenés:ChemistrySelect 1 : 10 (2016), p. 2383-2388. -
További szerzők:Balla Sára Bényei Attila (1962-) (vegyész) Kumar, Ambati Ashok Timári István (1989-) (vegyész) Kövér Katalin, E. (1956-) (vegyész) Szilágyi László (1941-) (vegyész)
Pályázati támogatás:NN 109671
OTKA
K 105459
OTKA
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001-es BibID:BIBFORM063926
035-os BibID:(WoS)000378965200027 (Scopus)84959921140
Első szerző:Parajdi-Losonczi Péter László (vegyész)
Cím:[(?6-p-cymene)Ru(H2O)3]2 + binding capability of aminohydroxamates - A Solution and Solid State Study / Péter László Parajdi-Losonczi, Attila Csaba Bényei, Éva Kováts, István Timári, Tereza Radosova Muchova, Vojtech Novohradsky, Jana Kasparkova, Péter Buglyó
Dátum:2016
ISSN:0162-0134
Megjegyzések:Complex forming capabilities of [(?6-p-cymene)Ru(H2O)3]2+ with aminohydroxamates (2-amino-N-hydroxyacetamide (?-alahaH), 3-amino-N-hydroxypropanamide (?-alahaH) and 4-amino-N-hydroxybutanamide?(?-abhaH)) having the primary amino group in different chelatable position to the hydroxamic function were studied by pH-potentiometry, NMR and MS methods. Formation of stable [O,O] and mixed [O,O][N,N] chelated mono- and dinuclear species is detected in partially slow with ?-alahaH and ?-alahaH or in fast processes with ?-abhaH and the formation constants of the complexes present in aqueous solution are reported. Synthesis, spectral (NMR, IR) and ESI mass spectrometric characterization of novel dinuclear ?-alaninehydroximato complexes containing the half-sandwich type Ru(II) core is described. The crystal and molecular structure of [{(?6-p-cymene)Ru}2(?2-?-alahaH?1)(H2O)Br]Br?H2O (1) and [{(?6-p-cymene)Ru}2(?2-?-alahaH?1)(H2O)Cl]BF4?H2O (2) was determined by single crystal X-ray diffraction method. In the complexes one half-sandwich core is coordinated by a hydroxamate [O,O] chelate while the other one by [Namino,Nhydroxamate] fashion of the bridging ligand. In both cases the remaining coordination sites of one of the Ru cores are taken by a halide ion whiles the other one by a water molecule. Reaction of 2 with 9-methylguanine indicates the N7 coordination of this simple DNA model. Complexes 1 and 2 were tested for their in vitro cytotoxicity using human-derived cancer cell lines (A2780, MCF-7, SKOV-3, HCT116, HeLa) and showed no anti-proliferative activity in the micromolar concentration range.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal Of Inorganic Biochemistry. - 160 (2016), p. 236-245. -
További szerzők:Bényei Attila (1962-) (vegyész) Kováts Éva (1977-) (vegyész) Timári István (1989-) (vegyész) Radosova Muchova, Tereza Novohradsky, Vojtech Kasparkova, Jana Buglyó Péter (1965-) (vegyész)
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