Találati lista | Tudóstér

001-es BibID:	BIBFORM106441
035-os BibID:	(WoS)000942361700007 (Scopus)85147234942
Első szerző:	Frendl István (baleseti sebész és kézsebész)
Cím:	Alcohol consumption affects the late endocrine consequences of mild traumatic brain injury / Istvan Frendl, Annamaria Erdei, Noemi Zsiros, Monika Katko, Erika Galgoczi, Zoltan Nemeti, Harjit Pal Bhattoa, Janos Kappelmayer, Janos Posta, Bela Turchanyi, Ferenc Urban, Endre V. Nagy
Dátum:	2022
ISSN:	0172-780X
Megjegyzések:	BACKGROUND: Currently there are no widely applied methods which could identify, at the time of head trauma, those mild traumatic brain injury (mTBI) patients who later develop pituitary dysfunction. The effect of alcohol consumption on post-TBI endocrine dysfunction is unclear. METHODS: Five hundred and eight TBI patients, 406 of them with mTBI, were studied. Sixty-one patients (46 males, 15 females) were available for follow- up. Admission serum samples were evaluated for S100B protein and markers of alcohol consumption: ethanol level for day-of-injury intake and carbohydrate deficient transferrin (CDT) level for regular alcohol consumption. Regular alcohol consumption was defined as CDT > 1.5%, including both social and heavy drinkers. Admission and one-year follow-up samples were evaluated for pituitary dysfunction. RESULTS: Newly developed pituitary hormone deficiency was found in 16% of mTBI patients. When cohorts developing and not developing late pituitary dysfunction were compared, 30% and 69% of patients were regular alcohol consumers, respectively (p = 0.02). Neither S100B level nor day-of-injury alcohol consumption was predictive of late pituitary dysfunction. CONCLUSION: The findings of this preliminary study suggest that regular alcohol consumption may protect against the late endocrine consequences of mTBI. Alcohol intake during the weeks preceding mTBI may identify patients at higher risk for late pituitary dysfunction.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Neuroendocrinology Letters. - 43 : 4 (2022), p. 239-245. -
További szerzők:	Erdei Annamária (1976-) (belgyógyász) Zsíros Noémi (1986-) (belgyógyász) Katkó Mónika (1980-) (biológus) Galgóczi Erika (1986-) (biológus) Németi Zoltán Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Kappelmayer János (1960-) (laboratóriumi szakorvos) Posta János (1964-) (vegyész, toxikológus) Turchányi Béla (1957-) (traumatológus) Urbán Ferenc Nagy Endre V. (1957-) (belgyógyász, endokrinológus)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00005 GINOP
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM103913
Első szerző:	Katkó Mónika (biológus)
Cím:	The effect of iatrogenic hypothyroidism on lipoprotein subfractions and serum paraoxonase activity in patients with differentiated thyroid cancer / Katkó M., Gazdag A., Harangi M., Szentpéteri A., Galgóczi E., Erdei A., Berta E., Bodor M., Bhattoa H. P., Nagy E. V.
Dátum:	2022
ISSN:	0021-9150
Megjegyzések:	Background and Aims : The development of atherogenic lipid profile has a major role in hypothyroidism induced accelerated atherosclerosis. In a group of patients with differentiated thyroid cancer (DTC) subclinical hyperthyroidism is maintained after thyroidectomy, interrupted annually with short-term overt hypothyroidism for diagnostic purposes. The effects of short-term overt hypothyroidism on lipid parameters, lipoprotein subfractions and paraoxonase-1 (PON1) activity were studied in these patients. Methods: Twenty-one patients who underwent total thyroidectomy and ablative radioiodine therapy for DTC were enrolled in the study. Blood samples were collected during continuous TSH-suppressive levothyroxine (L-T4) therapy and after four weeks of L-T4 withdrawal. Thyroid hormones, lipid parameters and PON1 paraoxonase and arylesterase activity were measured, analysis of lipoprotein subfractions was performed by Lipoprint system. Results: Compared to values measured during continuous L-T4 therapy, total cholesterol, HDL-C, LDL-C, ApoA1, ApoB levels were significantly elevated during iatrogenic hypothyroidism. Differences in the subfraction pattern of lipoproteins were also observed: in hypothyroidism, the mean LDL size decreased (26.9?0.4 nm vs 27.1?0.4 nm, p<0.01) and the proportion of small and medium-sized HDL subfractions decreased (29.5?9.9% vs 33.8?8.6%, p<0.001, and 43.8?4.6% vs 46.1?5.1%, p=0.005, respectively), while the proportion of large HDL subfractions increased (26.8?9.8% vs 20.0?6.9%, p<0.0001). The PON1 paraoxonase and arylesterase activities were increased during L-T4 withdrawal (113?67 U/L vs 106?67 U/L, p=0.005; and 159?44 U/L vs 134?21 U/L, p<0.01; respectively). Conclusions: In short-term overt hypothyroidism both atherogenic and anti-atherogenic changes were found: the shift toward lower density LDL subfractions is atherogenic, while the increased proportion of larger HDL subfractions and increased paraoxonase activity are anti-atherogenic.
Tárgyszavak:	Orvostudományok Egészségtudományok idézhető absztrakt folyóiratcikk iatrogenic hypothyroidism differentiated thyroid cancer paraoxonase-1 lipoprotein subfraction lipid metabolism
Megjelenés:	Atherosclerosis. - 355 (2022), p. e163. -
További szerzők:	Gazdag Annamária (1979-) (belgyógyász) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Szentpéteri Anita (1988-) (biológus) Galgóczi Erika (1986-) (biológus) Erdei Annamária (1976-) (belgyógyász) Berta Eszter (1980-) (belgyógyász) Bodor Miklós (1969-) (belgyógyász, endokrinológus) Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Nagy Endre V. (1957-) (belgyógyász, endokrinológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM094546
Első szerző:	Katkó Mónika (biológus)
Cím:	The 4G/5G Polymorphism of Plasminogen Activator Inhibitor Type 1 is a Predictor of Moderate-to-Severe Thyroid Eye Disease / Monika Katko, Erika Galgoczi, Annamaria Erdei, Annamaria Gazdag, Eszter Berta, Miklos Bodor, Ildiko Seres, Ildiko Hircsu, Arpad Badics, Bernadett Ujhelyi, Livia Sira, Harjit Pal Bhattoa, Endre V. Nagy
Dátum:	2021
ISSN:	1178-7031
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal of Inflammation Research. - 14 (2021), p. 1883-1890. -
További szerzők:	Galgóczi Erika (1986-) (biológus) Erdei Annamária (1976-) (belgyógyász) Gazdag Annamária (1979-) (belgyógyász) Berta Eszter (1980-) (belgyógyász) Bodor Miklós (1969-) (belgyógyász, endokrinológus) Seres Ildikó (1954-) (biokémikus) Hircsu Ildikó Badics Árpád Ujhelyi Bernadett (1981-) (szemész) Sira Lívia (1973-) (endokrinológus) Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Nagy Endre V. (1957-) (belgyógyász, endokrinológus)
Pályázati támogatás:	NKFIH K116419 NKFIH
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: