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001-es BibID:BIBFORM072268
Első szerző:Kardos Zsófia
Cím:Increased frequency of temporal acoustic window failure in rheumatoid arthritis : a manifestation of altered bone metabolism? / Kardos Zsófia, Oláh Csaba, Sepsi Mariann, Sas Attila, Kostyál László, Bóta Tünde, Bhattoa Harjit Pal, Hodosi Katalin, Kerekes György, Tamási László, Bereczki Dániel, Szekanecz Zoltán
Megjegyzések:Assessment of intracranial vessels includes transcranial Doppler (TCD). TCD performance requires intact temporal acousticwindows (TAW). Failure of TAW (TAWF) is present in 8?20% of people. There have been no reports on TAWF in rheumatoidarthritis (RA). Altogether, 62 female RA patients were included. Among them, 20 were MTX-treated and biologic-free, 20received infliximab, and 22 tocilizumab. The controls included 60 non-RA women. TAWF, temporal bone thickness, and texturewere determined by ultrasound and CT. BMD and T-scores of multiple bones were determined by DEXA. Several bonebiomarkers were assessed by ELISA. In RA, 54.8% of the patients had TAWF on at least one side. Neither TAW could beidentified in 34% of RA subjects. In contrast, only 20.0% of control subjects had TAWF on either or both sides (p < 0.001). In RAvs controls, 53.0 vs 2.9% of subjects exerted the trilayer, Bsandwich-like^ structure of TAW (p < 0.001). Finally, in RA vscontrols, the mean temporal bone thickness values of the right TAW were 3.58 ? 1.43 vs 2.92 ? 1.22 mm (p = NS), while thoseof the left TAW were 4.16 ? 1.56 vs 2.90 ? 1.16 mm (p = 0.001). There was close association between TAWF, bone thickness,and texture (p < 0.05). These TAW parameters all correlated with age; however, TAW failure and texture also correlated withserum osteoprotegerin. TAW bone thickness inversely correlated with hip BMD (p < 0.05). TAWF, thicker, and heterogeneoustemporal bones were associated with RA. These features have been associated with bone loss and OPG production. Bone lossseen in RA may result in OPG release and stimulation of bone formation around TAW.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Biological therapy
Reumatoid arthritis
Temporal acoustic window failure
Megjelenés:Clinical Rheumatology. - 37 : 5 (2018), p. 1183-1188. -
További szerzők:Oláh Csaba (1972-) (idegsebész) Sepsi Marianna Sas Attila Kostyál László (1974-) (radiológus) Bóta Tünde Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Hódosi Katalin Kerekes György (1973-) (belgyógyász, kardiológus, angiológus) Tamási László Bereczki Dániel (1960-) (neurológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
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001-es BibID:BIBFORM070695
Első szerző:Oláh Csaba (idegsebész)
Cím:Assessment of intracranial vessels in association with carotid atherosclerosis and brain vascular lesions in rheumatoid arthritis / Csaba Oláh, Zsófia Kardos, Mariann Sepsi, Attila Sas, László Kostyál, Harjit Pal Bhattoa, Katalin Hodosi, György Kerekes, László Tamási, Attila Valikovics, Dániel Bereczki, Zoltán Szekanecz
ISSN:1478-6354 1478-6362
Megjegyzések:Background: Stroke has been associated with rheumatoid arthritis (RA). We assessed patients with RA and healthycontrol subjects by transcranial Doppler (TCD), carotid ultrasonography and brain magnetic resonance imaging (MRI).Methods: Altogether, 41 female patients with RA undergoing methotrexate (MTX) or biologic treatment and 60age-matched control subjects underwent TCD assessment of the middle cerebral artery (MCA) and basilar artery.Pulsatility index (PI), resistivity (resistance) index (RI) and circulatory reserve capacity (CRC) were determined at rest (r)and after apnoea (a) and hyperventilation (h). The presence of carotid plaques and carotid intima-media thickness(cIMT) were also determined. Intracerebral vascular lesions were investigated by brain MRI.Results: MCA PI and RI values at rest and after apnoea were significantly increased in the total and MTX-treated RApopulations vs control subjects. MCA CRC was also impaired, and basilar artery PI was higher in RA. More patientswith RA had carotid plaques and increased cIMT. Linear regression analysis revealed that left PI(r) and RI(r) correlatedwith disease duration and that left PI(r), RI(r), PI(a), PI(h) and basilar PI correlated with disease activity. Right CRCinversely correlated with 28-joint Disease Activity Score. Disease activity was an independent determinant of left PI(a)and right CRC. Compared with long-term MTX treatment alone, the use of biologics in combination with MTX wasassociated with less impaired cerebral circulation. Impaired cerebral circulation was also associated with measures ofcarotid atherosclerosis.Conclusions: To our knowledge, this is the first study to show increased distal MCA and basilar artery occlusion in RAas determined by TCD. Patients with RA also had CRC defects. We also confirmed increased carotid plaque formationand increased cIMT. Biologics may beneficially influence some parameters in the intracranial vessels.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Arthritis Research & Therapy 19 : 1 (2017), p. 213. -
További szerzők:Kardos Zsófia Sepsi Marianna Sas Attila Kostyál László (1974-) (radiológus) Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Hódosi Katalin Kerekes György (1973-) (belgyógyász, kardiológus, angiológus) Tamási László Valikovics Attila Bereczki Dániel (1960-) (neurológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
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