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001-es BibID:	BIBFORM073024
035-os BibID:	(WoS)000366646400029 (Scopus)84951907147
Első szerző:	Tóth Dezső (sebész, onkológus)
Cím:	Predictive Factors for Positive Margin and the Surgical Learning Curve in Non-Palpable Breast Cancer After Wire-Guided Localization - Prospective Study of 214 Consecutive Patients / Dezső Tóth, Zsolt Varga, Éva Sebő, Miklós Török, Ilona Kovács
Dátum:	2016
ISSN:	1219-4956 1532-2807
Megjegyzések:	To investigate the most commonly used technique, the wire-guided localization (WGL) in non-palpable breast cancer. To analyze the effective factors on positive surgical margins in our practice and determine the surgical learning curve of this method. Prospective consecutive study was performed from January 2005 to December 2011. Inclusion criteria was a non-palpable breast lesion with malignancy on preoperative histology. All lesions were localized by ultrasound or stereotactic guided wire placement. Margins 1 mm or closer were accepted as positive margins which required re-excision. To determine the learning curve of WGL method we investigated the change in the reoperation rate after primary procedure performed by "high-volume" surgeon. Two hundred and fourteen consecutive patients were enrolled. In 23 patients (10.7%) reexcision was needed. Positive surgical margins were significantly influenced by the patient's age (p?=?0.03), tumor volume (p?<?=0.001), proportion of tumor volume/specimen volume (p?<?0.001), presence of DCIS (p?<?0.001), multifocality (p?=?0.03) and the learning curve (p?=?0.006) with univariate analysis. Only the tumor volume, presence of DCIS and the learning curve were proved as independent prognostic factor for reoperation by multivariate analysis. The reoperation rate decreased below 20% after the fortieth operation. Results of our single institutional study suggest, that this localization technique can be performed safely with very good results after 40 procedures as a learning curve for surgeons.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Breast cancer Learning curve Non-palpable Surgery Wire-guided localization
Megjelenés:	Pathology & Oncology Research. - 22 : 1 (2016), p. 209-215. -
További szerzők:	Varga Zsolt József (1987-) (orvos) Sebő Éva Török Miklós (1976-) (pathológus) Kovács Ilona (1965-) (patológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM073028
035-os BibID:	(Scopus)85041094885 (WOS)000429808200024
Első szerző:	Tóth Dezső (sebész, onkológus)
Cím:	Short- and Long-Term (10-year) Results of an Organized, Population-Based Breast Cancer Screening Program : comparative, Observational Study from Hungary / Dezső Tóth, Zsolt Varga, Judit Tóth, Péter Árkosy, Éva Sebő
Dátum:	2018
ISSN:	0364-2313
Megjegyzések:	BACKGROUND:A nationwide breast cancer screening program was introduced in Hungary in the year 2002 for women aged 45-65 years to be performed biannually.METHODS:To investigate and report the short-term and 10-year follow-up results, we analyzed our Breast Unit's prospectively led database of screened (Group A) and age-matched symptomatic (Group B) patients from 2002 to 2007. We compared the clinicopathologic features of tumors and the impact of screening on surgical treatment, as well as the overall (OS), disease-specific (DSS) and disease-free survival (DFS) of different groups.RESULTS:Data from 208 screen-detected and 101 symptomatic patients between 45 and 65 years of age were examined. Screen-detected women were younger (54 vs. 58.5 years; p = 0.001) had significantly smaller tumors (15.5 vs. 17 mm; p = 0.044), and more breast-conserving surgery (68.8 vs. 59.4%; p = 0.032). Survival statistics were not statistically different at the median follow-up of 123 months; however, there was a trend toward improved DFS in Group A (82.7 vs. 74.3%; p = 0.074).CONCLUSIONS:Our study showed a significant reduction in rates of mastectomy in the screen-detected group in the short term, which does not translate into better survival rates based on initial long-term data. In order to realize the real advantage of this newly enstated screening program, a longer period of investigation is needed.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	World Journal Of Surgery. - 42 : 5 (2018), p. 1396-1402. -
További szerzők:	Varga Zsolt József (1987-) (orvos) Tóth Judit Árkosy Péter (1962-) (általános sebész, mellkassebész) Sebő Éva
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM073046
Első szerző:	Varga Zsolt József (orvos)
Cím:	Breast Cancer in Surgical Site : unusual Presentation of an Ectopic Milk Line Malignancy / Zsolt Varga, Miklós Török, Éva Sebő, Judit Tóth, Dezső Tóth
Dátum:	2016
Megjegyzések:	Primary ectopic breast cancer is a rare entity, which is mistaken for other benign skin or soft tissue lesions, easily.A 56-year old woman with history of laparoscopic cholecystectomy was referred to outpatient clinic 3 years after the operation with a non- healing reddish lump in the surgical scar. The lesion was situated at the site of the right subcostal port, in the medioclavicular line, below the ribcage. Local excision was performed and histological evaluation revealed poorly differentiated adenocarcinoma, which was thought to be metastatic. After multiple recurrences, appearance of an axillary lymph node metastasis and persistent search without any sign of other tumor, it had to be considered as a possibility, if there is no distant source of metastases, rather than a the lesion is a primary cancer. Relying on its location, behavior and result of immunohistochemistry, multidisciplinary team identi ed the lesion as triple-negative ectopic breast cancer. We performed a radical excision extended to the peritoneum, including partial, 3 cm long resection of the eleventh rib and a level II. Right-sided axillary block dissection was done simultaneously. The abdominal wall was reconstructed with component separation technique combining polypropylene and polytetra uoroethylene meshes. The multidisciplinary team proposed a treatment for triple- negative ectopic milk-line breast cancer, containing 4 cycles of TAC chemotherapy and fractionated 50 Gray dose of local radiotherapy. This adjuvant oncological treatment is in progress.This entity should be considered in differential diagnosis in cases of adenocarcinomas close to normal breasts and in the line of embryonic mammary ridges. So, we can avoid a signi cant delay in treatment and we can offer a better prognosis for the patient.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Breast cancer Ectopic breast Aberrant breast tissue Milk line Surgery
Megjelenés:	International Journal of Cancer and Clinical Research. - 3 : 1 (2016), p. 1-3. -
További szerzők:	Török Miklós (1976-) (pathológus) Sebő Éva Tóth Judit Tóth Dezső (1972-) (sebész, onkológus)
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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