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001-es BibID:BIBFORM109257
035-os BibID:(Scopus)85149477136 (WoS)000942239000001
Első szerző:Csernus Brigitta (élelmiszerbiztonsági és -minőségi mérnök)
Cím:Capsanthin supplementation modulates the immune response in broiler chickens under Escherichia coli lipopolysaccharide challenge / Brigitta Csernus, Csaba Szabó, Renáta Knop, Reda Gebrehaweria Kidane, Sawadi Fransisco Ndunguru, Gabriella Gulyás, Xénia Erika Ozsváth, Levente Czeglédi
Dátum:2023
ISSN:2363-9822
Megjegyzések:Due to the legislation of antibiotic usage, natural substances are required for application in the poultry industry. Because of their potential anti-inflammatory and immunomodulatory effects, carotenoids are great sources. Capsanthin, a major carotenoid giving the red color of pepper, is a promising feed additive, as it can reduce chronic inflammation. This study was conducted to determine the effects of capsanthin supplementation at 80 mg kg?1 in feed on the immune response of broiler chickens under Escherichia coli O55:B5 lipopolysaccharide (LPS) challenge. Ross 308 male broilers were divided into treatments: control (basal diet) and feedsupplemented groups. At 42 d of age, chickens were weighed and then challenged with 1 mg LPS per kilogram of body weight intraperitoneally. Four hours after injection, birds were euthanized, and then spleen and blood samples were collected. Capsanthin supplement at 80 mg kg?1 did not change the growth parameters and the relative spleen weight. LPS immunization resulted in higher splenic interleukin-1? (IL-1?), interleukin-6 (IL-6), and interferon-? (IFN-? ) mRNA expressions. Capsanthin addition reached lower gene expression levels of IL-6 and IFN-? compared to the LPS-injected birds. At plasma level, dietary capsanthin resulted in lower IL-1? and IL-6 levels. These results may indicate the potential anti-inflammatory effect of capsanthin supplementation in broiler chickens.
Tárgyszavak:Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
capsanthin
broiler chicken
gene expression
immunology
Megjelenés:Archives Animal Breeding. - 66 : 1 (2023), p. 103-111. -
További szerzők:Szabó Csaba (1968-) (agrármérnök) Knop Renáta (1983-) (állatorvos) Reda, Gebrehaweria Kidane (Phd hallgató) Ndunguru, Sawadi Fransisco (1980-) Gulyás Gabriella (1985-) (agrár) Ozsváth Xénia Erika Czeglédi Levente (1977-) (agrármérnök)
Pályázati támogatás:TKP2020-NKA-04
Egyéb
ÚNKP20-4-I-DE-101
Egyéb
K139021
OTKA
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Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM118530
035-os BibID:(WoS)001175647600001 (Scopus)85184758825
Első szerző:Lugata, James Kachungwa (Ph.D hallgató)
Cím:Methionine sources and genotype affect embryonic intestinal development, antioxidants, tight junctions, and growth-related gene expression in chickens / James K. Lugata, Sawadi F. Ndunguru, Gebrehaweria K. Reda, Xenia E. Ozsváth, Eszter Angyal, Levente Czegledi, Gabriella Gulyas, Renata Knop, Janos Oláh, Zoltan Mészár, Rita Varga, Brigitta Csernus, Csaba Szabo
Dátum:2024
ISSN:2405-6545
Megjegyzések:Methionine (Met) is an essential and first limiting amino acid in the poultry diet that plays a significant role in chicken embryonic development and growth. The present study examined the effect of in ovo injection of DL-Met and L-Met sources and genotypes on chicken embryonic-intestinal development and health. Fertilized eggs of the two genotypes, TETRA -SL layer hybrid (TSL) d commercial layer hybrid and Hungarian Partridge colored hen breed (HPC) d a native genotype, were randomly distributed into four treatments for each genotype. The treatment groups include the following: 1) control non-injected eggs (NoIn); 2) saline-injected (SaIn); 3) DL-Met injected (DLM); and 4) L-Met injected (LM). The in ovo injection was carried out on 17.5 d of embryonic development; after hatching, eight chicks per group were sacrificed, and the jejunum was extracted for analysis. The results showed that both DLM and LM groups had enhanced intestinal development as evidenced by increased villus width, villus height, and villus area (P < 0.05) compared to the control. The DLM group had significantly reduced crypt depth, glutathione content (GSH), glutathione S-transferase 3 alpha (GST3), occludin (OCLN) gene expression and increased villus height to crypt depth ratio in the TSL genotype than the LM group (P < 0.05). The HPC genotype has overexpressed insulin -like growth factor 1 (IGF1) gene, tricellulin (MD2), occludin (OCLN), superoxide dismutase 1 (SOD1), and GST3 genes than the TSL genotype (P < 0.05). In conclusion, these findings showed that in ovo injection of Met enhanced intestinal development, and function, with genotypes responding differently under normal conditions. Genotypes also influenced the expression of intestinal antioxidants, tight junction, and growth-related genes.
Tárgyszavak:Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
DL-Methionine
L-Methionine
In ovo injection
Intestinal development
Poultry
Megjelenés:Animal Nutrition. - 16 (2024), p. 218-230. -
További szerzők:Ndunguru, Sawadi Fransisco (1980-) Reda, Gebrehaweria Kidane (Phd hallgató) Ozsváth Xénia Erika Angyal Eszter Czeglédi Levente (1977-) (agrármérnök) Gulyás Gabriella (1985-) (agrár) Knop Renáta (1983-) (állatorvos) Oláh János (1976-) (állattenyésztés) Mészár Zoltán Mihály (1977-) (agrármérnök) Varga Rita Csernus Brigitta (1991-) (élelmiszerbiztonsági és -minőségi mérnök) Szabó Csaba (1968-) (agrármérnök)
Pályázati támogatás:K 139021
Egyéb
Stipendium Hungaricum Scholarship
Egyéb
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Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM119806
Első szerző:Ndunguru, Sawadi Fransisco (1980-)
Cím:Embryonic methionine triggers post-natal developmental programming in Japanese quail / Ndunguru, Sawadi F.; Reda, Gebrehaweria K.; Csernus, Brigitta; Knop, Renáta; Gulyás, Gabriella; Szabó, Csaba; Czeglédi, Levente; Lendvai, Ádám Z.
Dátum:2024
ISSN:0174-1578
Megjegyzések:Embryonic development is one of the most sensitive and critical stages when maternal effects may influence the offspring's phenotype. In birds and other oviparous species, embryonic development is confined to the eggs, therefore females must deposit resources into the eggs to prepare the offspring for the prevailing post-natal conditions. However, the mechanisms of such phenotypic adjustments remain poorly understood. We simulated a maternal nutritional transfer by injecting 1 mg of l-methionine solution into Japanese quail eggs before the onset of incubation. The increase in early methionine concentration in eggs activated the insulin/insulin-like signalling and mechanistic target of rapamycin (IIS/mTOR) signalling pathways and affected post-natal developmental trajectories. Chicks from methionine-supplemented eggs had higher expression of liver IGF1 and mTOR genes at hatching but were similar in size, and the phenotypic effects of increased growth became apparent only a week later and remained up to three weeks. Circulating levels of insulin-like growth factor-1 (IGF-1) and expression of ribosomal protein serine 6 kinase 1 (RPS6K1), the mTOR downstream effector, were elevated only three weeks after hatching. These results show that specific nutritional cues may have phenotypic programming effects by sequentially activating specific nutrient-sensing pathways and achieving transgenerational phenotypic plasticity.
Tárgyszavak:Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
L-methionine
IGF1
mTOR
Growth
Amino acid
Megjelenés:Journal Of Comparative Physiology B-Biochemical Systemic And Environmental Physiology. - Epub (2024), p. 1-11. -
További szerzők:Reda, Gebrehaweria Kidane (Phd hallgató) Csernus Brigitta (1991-) (élelmiszerbiztonsági és -minőségi mérnök) Knop Renáta (1983-) (állatorvos) Gulyás Gabriella (1985-) (agrár) Szabó Csaba (1968-) (agrármérnök) Czeglédi Levente (1977-) (agrármérnök) Lendvai Ádám Zoltán (1977-) (biológus)
Pályázati támogatás:K139021
OTKA
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM120370
Első szerző:Reda, Gebrehaweria Kidane (Phd hallgató)
Cím:Dietary restriction reveals sex-specifc expression of the mTOR pathway genes in Japanese quails / Gebrehaweria K. Reda, Sawadi F. Ndunguru, Brigitta Csernus, Renáta Knop, James K. Lugata, Csaba Szabó, Levente Czeglédi, Ádám Z. Lendvai
Dátum:2024
ISSN:2045-2322
Megjegyzések:Limited resources affect an organism's physiology through the conserved metabolic pathway, the mechanistic target of rapamycin (mTOR). Males and females often react differently to nutritional limitation, but whether it leads to differential mTOR pathway expression remains unknown. Recently, we found that dietary restriction (DR) induced significant changes in the expression of mTOR pathway genes in female Japanese quails (Coturnix japonica). We simultaneously exposed 32 male and female Japanese quails to either 20%, 30%, 40% restriction or ad libitum feeding for 14 days and determined the expression of six key genes of the mTOR pathway in the liver to investigate sex differences in the expression patterns. We found that DR significantly reduced body mass, albeit the effect was milder in males compared to females. We observed sex-specific liver gene expression. DR downregulated mTOR expression more in females than in males. Under moderate DR, ATG9A and RPS6K1 expressions were increased more in males than in females. Like females, body mass in males was correlated positively with mTOR and IGF1, but negatively with ATG9A and RS6K1 expressions. Our findings highlight that sexes may cope with nutritional deficits differently and emphasise the importance of considering sexual differences in studies of dietary restriction.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Scientific Reports. - 14 : 1 (2024), p. 1-14. -
További szerzők:Ndunguru, Sawadi Fransisco (1980-) Csernus Brigitta (1991-) (élelmiszerbiztonsági és -minőségi mérnök) Knop Renáta (1983-) (állatorvos) Lugata, James Kachungwa (1992-) (Ph.D hallgató) Szabó Csaba (1968-) (agrármérnök) Czeglédi Levente (1977-) (agrármérnök) Lendvai Ádám Zoltán (1977-) (biológus)
Pályázati támogatás:K139021
OTKA
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

5.

001-es BibID:BIBFORM120372
Első szerző:Reda, Gebrehaweria Kidane (Phd hallgató)
Cím:Dietary restriction and life-history trade-offs: insights into mTOR pathway regulation and reproductive investment in Japanese quails / Gebrehaweria K. Reda, Sawadi F Ndunguru, Brigitta Csernus, Gabriella Gulyás, Renáta Knop,Csaba Szabó, Levente Czeglédi, Ádám Z. Lendvai
Dátum:2024
ISSN:0022-0949
Megjegyzések:Resources are needed for growth, reproduction and survival, and organisms must trade-off limited resources among competing processes. Nutritional availability in organisms is sensed and monitored by nutrient-sensing pathways that can trigger physiological changes or alter gene expression. Previous studies have proposed that one such signalling pathway, the mechanistic target of rapamycin (mTOR), underpins a form of adaptive plasticity when individuals encounter constraints in their energy budget. Despite the fundamental importance of this process in evolutionary biology, how nutritional limitation is regulated through the expression of genes governing this pathway and its consequential effects on fitness remains understudied, particularly in birds. We used dietary restriction to simulate resource depletion and examined its effects on body mass, reproduction and gene expression in Japanese quails (Coturnix japonica). Quails were subjected to feeding 20%, 30%, 40% restriction levels or ad libitum for two weeks. All restricted groups exhibited reduced body mass, whereas reductions in the number and mass of eggs were observed only under more severe restrictions. Additionally, dietary restriction led to decreased expression of mTOR and insulin-like growth factor 1 (IGF1), whereas the ribosomal protein S6 kinase 1 (RPS6K1) and autophagy-related genes (ATG9A and ATG5) were upregulated. The pattern in which mTOR respond to restriction was similar to what has been seen in body mass. Regardless of the treatment, proportionally higher reproductive investment was associated with individual variation in mTOR expression. These findings reveal the connection between dietary intake and the expression of mTOR and related genes in this pathway.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal Of Experimental Biology. - [Epub ahead of print] : - (2024), p. -. -
További szerzők:Ndunguru, Sawadi Fransisco (1980-) Csernus Brigitta (1991-) (élelmiszerbiztonsági és -minőségi mérnök) Gulyás Gabriella Knop Renáta (1983-) (állatorvos) Szabó Csaba Czeglédi Levente (1977-) (agrármérnök) Lendvai Ádám Zoltán (1977-) (biológus)
Pályázati támogatás:K139021
OTKA
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
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