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001-es BibID:	BIBFORM116986
035-os BibID:	(cikkazonosító)e3002413 (WoS)001113744200011 (Scopus)85180004955
Első szerző:	Huang, Zan
Cím:	Supraclavicular brown adipocytes originate from Tbx1+ myoprogenitors / Huang Zan, Gu Chenxin, Zhang Zengdi, Arianti Rini, Swaminathan Aneesh, Tran Kevin, Battist Alex, Kristóf Endre, Ruan Hai-Bin
Dátum:	2023
ISSN:	1544-9173 1545-7885
Megjegyzések:	Brown adipose tissue (BAT) dissipates energy as heat, contributing to temperature control, energy expenditure, and systemic homeostasis. In adult humans, BAT mainly exists in supraclavicular areas and its prevalence is associated with cardiometabolic health. However, the developmental origin of supraclavicular BAT remains unknown. Here, using genetic cell marking in mice, we demonstrate that supraclavicular brown adipocytes do not develop from the Pax3(+)/Myf5(+) epaxial dermomyotome that gives rises to interscapular BAT (iBAT). Instead, the Tbx1(+) lineage that specifies the pharyngeal mesoderm marks the majority of supraclavicular brown adipocytes. Tbx1(Cre)-mediated ablation of peroxisome proliferator-activated receptor gamma (PPAR gamma) or PR/SET Domain 16 (PRDM16), components of the transcriptional complex for brown fat determination, leads to supraclavicular BAT paucity or dysfunction, thus rendering mice more sensitive to cold exposure. Moreover, human deep neck BAT expresses higher levels of the TBX1 gene than subcutaneous neck white adipocytes. Taken together, our observations reveal location-specific developmental origins of BAT depots and call attention to Tbx1(+) lineage cells when investigating human relevant supraclavicular BAT.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Plos Biology. - 21 : 12 (2023), p. 1-19. -
További szerzők:	Gu, Chenxin Zhang, Zengdi Arianti, Rini (1991-) (biokémikus) Swaminathan, Aneesh Tran, Kevin Battist, Alex Kristóf Endre (1987-) (általános orvos) Ruan, Hai-Bin
Pályázati támogatás:	FK131424 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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