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001-es BibID:	BIBFORM096555
035-os BibID:	(Scopus)85116986339 (WoS)000706939900001
Első szerző:	Ding, Yuchao (Ph.D. hallgató)
Cím:	Progression and Regression of Abdominal Aortic Aneurysms in Mice / Yu-chao Ding, Xian-jing Zhang, Ji-xiu Zhang, Zi-yi Zhai, Mei-xia Zhang, Bao-hong Jiang
Dátum:	2021
Megjegyzések:	Abdominal aortic aneurysm (AAA) is a significant medical problem with a high mortality rate. Nevertheless, the underlying mechanism for the progression and regression of AAA is unknown. Methods: Experimental model of AAA was first created by porcine pancreatic elastase incubation around the infrarenal aorta of C57BL/6 mice. Then, AAA progression and regression were evaluated based on the diameter and volume of AAA. The aortas were excised for hematoxylin-eosin staining (HE), orcein staining, sirius red staining, immunofluorescence analysis and perls' prussian blue staining at the indicated time point following. Finally, ?-aminopropionitrile monofumarate (BAPN) was used to explore the underlying mechanism of the regression of AAA. Results: When we extended the observation period to 100 days, we not only observed an increase in the AAA diameter and volume in the early stage, but also a decrease in the late stage. Consistent with AAA diameter and volume, the aortic thickness showed the same tendency based on HE staining. The elastin and collagen content first degraded and then regenerated, which corresponds to the early deterioration and late regression of AAA. Then, endogenous up-regulation of lysyl oxidase (LOX) was detected, accompanying the regression of AAA, as detected by an immunofluorescent assay. BAPN and LOX inhibitor considerably inhibited the regression of AAA, paralleling the degradation of elastin lamella and collagen. Conclusion: Taken together, we tentatively conclude that endogenous re-generation of LOX played an influential role in the regression of AAA. Therefore, regulatory factors on the generation of LOX exhibit promising therapeutic potential against AAA.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk abdominal aortic aneurysm disease progression disease regression elastogenesis lysyl oxidase
Megjelenés:	Current Medical Science. - 41 : 5 (2021), p. 901-908. -
További szerzők:	Zhang, Xianjing Zhang, Ji-xiu Zhai, Ziyi Zhang, Mei-xia Jiang, Baohong
Internet cím:	DOI Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM121330
Első szerző:	Jiang, Baohong
Cím:	Medicine for treating artery related diseases and application thereof / Jiang Baohong, Zhang Xianjing, Ding Yuchao, Zhai Ziyi
Dátum:	2021
Megjegyzések:	The invention provides a medicament for treating artery-related diseases and application thereof. In particular, the invention provides the application of a compound shown in the formula I in treating artery related diseases. Experiments show that the compound of the formula I has obvious curative effect on arterial lesions such as aneurysm, intermural hematoma and/or arterial dissection.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok szabadalom oltalmi forma
További szerzők:	Zhang, Xianjing Ding, Yuchao (1995-) (Ph.D. hallgató) Zhai, Ziyi
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM096467
Első szerző:	Jiang, Baohong
Cím:	Drug for treating artery-related diseases, and use thereof / Jiang Baohong, Zhang Xianjing, Ding Yuchao, Zhai Ziyi
Dátum:	2021
Megjegyzések:	Provided are a drug for treating artery-related diseases and the use thereof. Specifically, provided are the use of a class of compounds of formula I in the treatment of artery-related diseases. Experiments show that the compounds of formula I have a significant effect on aneurysm, intermural hematoma and/or arterial dissection.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok szabadalom oltalmi forma
További szerzők:	Zhang, Xianjing Ding, Yuchao (1995-) (Ph.D. hallgató) Zhai, Ziyi
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM121477
035-os BibID:	(Scopus)85124551136 (WoS)000752203700001
Első szerző:	Zhai, Ziyi
Cím:	Eugenol restrains abdominal aortic aneurysm progression with down-regulations on NF-?B and COX-2 / Ziyi Zhai, Xianjing Zhang, Yuchao Ding, Ziming Huang, Qian Li, Mingyue Zheng, Kenka Cho, Zhihui Dong, Weiguo Fu, Zaixing Chen, Baohong Jiang
Dátum:	2022
ISSN:	0951-418X
Megjegyzések:	Abdominal aortic aneurysm (AAA) is a lethal disease without available medicine for treatment. This study aimed to evaluate the efficiency of eugenol (4-allyl2-methoxyphenol) against AAA and the underlying mechanism. Eugenol is the major bioactive component of clove. A mouse AAA model was established through porcine pancreatic elastase (PPE) incubation peri-adventitially and 1% 3-aminopropanonitrile (BAPN) diet. Continuous AAA progression from day 0 to day 15 was observed after PPE plus BAPN treatment, according to the AAA diameter and histopathological evaluation. Accompanying with AAA progression, sustained increased expressions of CD68, COX-2 and NF-?B were observed through immunofluorescence assay. After elucidation the efficiency of eugenol against AAA progression by AAA diameter, hematoxylin?eosin staining and orcein staining, the down-regulations of eugenol on COX-2 and NF-?B were further detected by immunohistochemistry and western blot. Eugenol not only blocked AAA expansion and protected the integrity of aortic structure in a dose-dependent manner, but also held high oral bioavailability. Excellent efficiency, high oral bioavailability and down-regulation on COX-2/NF-?B endowed eugenol great potential for future AAA therapy
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk abdominal aortic aneurysm COX-2 eugenol NF-?B
Megjelenés:	Phytotherapy Research. - 36 : 2 (2022), p. 928-937. -
További szerzők:	Zhang, Xianjing Ding, Yuchao (1995-) (Ph.D. hallgató) Huang, Ziming Li, Qian Zheng, Mingyue Cho, Kenka Dong, Zhihui Fu, Weiguo Chen, Zaixing Jiang, Baohong
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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