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001-es BibID:	BIBFORM010284
Első szerző:	Miklós Ida (biológus)
Cím:	The pleiotropic cell separation mutation spl1-1 is a nucleotide substitution in the internal promoter of the proline tRNA(CGG) gene of Schizosaccharomyces pombe / Miklós Ida, Ludányi Katalin, Matthias Sipiczki
Dátum:	2009
Megjegyzések:	spl1-1 was originally identified as a spontaneous mutation genetically interacting with sep1-1 and cdc4-8 in producing multinucleate syncytia. This study shows that it is allelic with the proline-tRNA(CGG) gene SPATRNAPRO.02. Its nucleotide sequence contains a C -> T substitution in the region corresponding to the B-box of the putative intragenic promoter and the T psi C loop of the mature tRNA. The substitution drastically reduces the transcription efficiency of the gene and pleiotropically affects numerous cellular processes. spl1-1 cells are temperature sensitive, osmosensitive, bend at higher temperatures, have extended G2 phase and are defective in cell separation (septum cleavage). The proline-tRNA(TGG) gene SPATRNAPRO.01 can partially suppress the spl1-1 mutation when introduced into the cells on a multicopy plasmid. The effect of a mutation in a tRNA gene on cell separation brings a new element into the complexity of the regulation of cell division and its co-ordination with other cellular processes in Schizosaccharomyces pombe.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Cytokinesis Septum Transcription Cell cycle Fission yeast tRNA
Megjelenés:	Current Genetics. - 55 : 5 (2009), p. 511-520. -
További szerzők:	Ludányi Katalin (1975-) (immunológus) Sipiczki Mátyás (1948-) (biológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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