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1.

001-es BibID:BIBFORM100136
Első szerző:Csikós Anett (biomérnök, biológia-földrajz tanár)
Cím:Polymorphisms identification of SLC30A (ZnTs) and SLC39A (ZIPs) Family genes in Hungary / Csikós Anett, Miklós Ida, Takács Péter
Dátum:2018
Megjegyzések:Zinc is the second most common trace element and catalytic cofactor in the human body. Zinc plays an important role in wound healing, biosynthesis and homeostasis of various connective tissues. A large number of proteins are known to regulate cellular Zn homeostasis and the most significant proteins belong to two protein families of Zn transporters. The solute carrier family 30 (SLC30A, also called ZnTs) and solute carrier family 39 (SLC39A, also called ZIPs) regulate Zn influx and efflux in the cells as well as intracellular compartments. Over the past few years, new knowledge accumulated in the international literature concerning Zn transporters. Fourteen ZIP and 10 ZnT proteins have been identified. The Hungarian population has not been investigated so far. Our research aims to eliminate this shortage. The present study was designed to test single nucleotide polymorphisms (SNPs) of the SLC30A and SLC39A genes. Samples of human blood were collected from 32 Hungarian women before their surgery for benign gynecological reasons. 24 markers were designed for the genetic variability of Hungarian isolates. Zinc transport loci could be amplified successfully in all patient samples included in the analysis. Thus more, than seven hundred samples will be applied in this work. Our results suggest that the 24 primers tested were found to be appropriate tools to detect the genetic variability of zinc transporters in the human blood samples. These primers will be applied in further studies to reveal the structure of Zinc transporters of the Hungarian populations.
Tárgyszavak:Természettudományok Biológiai tudományok előadáskivonat
könyvrészlet
Megjelenés:A Magyar Mikrobiológiai Társaság 2018. évi Nagygyűlése és a XIII. Fermentációs Kollokvium : Absztraktfüzet. - p. 10-11.
További szerzők:Miklós Ida (1962-) (biológus) Takács Péter (1968-) (szülész-nőgyógyász)
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2.

001-es BibID:BIBFORM100095
Első szerző:Csikós Anett (biomérnök, biológia-földrajz tanár)
Cím:Comparison of novel single nucleotide polymorphisms of zinc transporters with zinc concentration in the human blood and vaginal tissues / Csikós Anett, Takacs Peter, Miklós Ida
Dátum:2020
ISSN:0966-0844
Megjegyzések:The most important proteins regulating cellular zinc homeostasis belong to two protein families of zinc transporters, the solute carrier family 30 (SLC30A) and solute carrier family 39 (SLC39A). We aimed to identify single nucleotide polymorphisms (SNPs) of the SLC30A and SLC39A genes and its association with blood and vaginal tissue zinc levels since vaginal tissue zinc level may play a role in vaginal remodeling and pathological conditions of the vagina. Blood and vaginal tissue samples were collected from women undergoing surgery for benign gynecological reasons. SNPs of twenty-four zinc transporters were determined by PCR/Sequence method, and the concentration of zinc was assessed by inductively coupled plasma optical emission spectrometry. Sequencing of selected exons revealed 16 SNPs, including five previously unidentified SNPs. Our data showed an association between the number of SNPs (more than six SNPs vs. less than six) per patient and high zinc vaginal tissue levels (67% vs. 33%, p < 0.01). The SLC39A4 SNP 590c A (rs17855765) was significantly more frequent in the group of women with high zinc vaginal tissue levels compared to the group without SNP (93% vs. 7%, p = 0.02). Also, our analysis revealed that the number of SNPs in SLC39A4 was significantly more frequent in patients with low zinc blood levels (76% vs. 24%, p = 0.01). Our findings indicate that different SNPs of the zinc transporter genes may have a significant effect on the blood and vaginal tissue zinc levels.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Biometals. - 33 : 6 (2020), p. 323-337. -
További szerzők:Takács Péter (1968-) (szülész-nőgyógyász) Miklós Ida (1962-) (biológus)
Pályázati támogatás:GINOP-2.1.1-15-2016- 00783
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3.

001-es BibID:BIBFORM093762
Első szerző:Csikós Anett (biomérnök, biológia-földrajz tanár)
Cím:Differential expression of zinc transporters in vaginal tissues / A. Csikós, B. Kozma, I. Miklós, A. Pór, I. Kovács, R. Lampé, P. Takács
Dátum:2020
Tárgyszavak:Orvostudományok Elméleti orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:Female Pelvic Medicine & Reconstructive Surgery. - 26 : 10S-Suppl1 (2020), p. S127. -
További szerzők:Kozma Bence (1982-) (szülész-nőgyógyász) Miklós Ida (1962-) (biológus) Pór Ágnes Kovács Ilona Lampé Rudolf (1983-) (szülész-nőgyógyász) Takács Péter (1968-) (szülész-nőgyógyász)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM091543
Első szerző:Csikós Anett (biomérnök, biológia-földrajz tanár)
Cím:Evaluation of zinc and copper levels in vaginal tissues and whole blood : correlation with age / Csikós Anett, Kozma Bence, Baranyai Edina, Miklós Ida, Larson Kindra, Póka Róbert, Takacs Peter
Dátum:2021
ISSN:1472-6874
Megjegyzések:Background: Zinc and copper are essential trace elements and play a crucial role in the homeostasis of connective tissues. In this study, we aimed to define zinc and copper levels in the vaginal tissue and establish whether a correlation exists between the zinc and copper levels either or both in whole blood or vaginal tissue samples and whether the finding correlates with the age of the patient or at least with her menopausal status. Methods: We collected whole blood and vaginal tissue samples from 32 women and measured their zinc and copper levels by inductively coupled plasma optical emission spectrometry. We have performed Student's t test to evaluate the differences in the mean levels of trace elements and multiple regression to evaluate the association between vaginal tissue zinc/copper levels and age, menopausal status, number of vaginal deliveries, and zinc/copper blood levels. Results: Zinc levels were significantly higher in both the vaginal tissues and whole blood samples than copper levels (p?<?0.01). In the vaginal tissue samples, a strong positive correlation could be detected between zinc and copper levels (r?=?0.82, p?<?0.01). In the vaginal tissue, a negative correlation was found for zinc and copper levels with the age of women (r?=???0.27, p?=?0.04 and r?=???0.56, p?<?0.01). Multiple linear regression model (age, menopausal status, vaginal delivery and copper/zinc blood levels) showed that only age remained a significant predictor for zinc and copper vaginal tissues levels (p?=?0.03, 95% CI ??2.28 to ??0.06; p?=?0.004, 95% CI ??1.76 to ??0.34). Conclusions: Zinc and copper levels in the vaginal tissue decline with age. Out of the examined variables (age, menopausal status, vaginal delivery, and copper/zinc levels), only age is a significant predictor of vaginal zinc/copper levels.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Ageing
Cooper
ICP-OES
Vagina
Whole blood
Zinc
Megjelenés:BMC Women's Health. - 21 : 1 (2021), p. 1-7. -
További szerzők:Kozma Bence (1982-) (szülész-nőgyógyász) Baranyai Edina (1987-) (környezetkutató) Miklós Ida (1962-) (biológus) Larson, Kindra Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus) Takács Péter (1968-) (szülész-nőgyógyász)
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DOI
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5.

001-es BibID:BIBFORM090310
Első szerző:Csikós Anett (biomérnök, biológia-földrajz tanár)
Cím:Zinc Transporter 9 (SLC30A9) Expression Is Decreased in the Vaginal Tissues of Menopausal Women / Csikós Anett, Kozma Bence, Pór Ágnes, Kovács Ilona, Lampé Rudolf, Miklós Ida, Takacs Peter
Dátum:2021
ISSN:0163-4984
Megjegyzések:Our aim was to compare zinc transporter (ZnT/SLC30A, and ZIP/SLC39A) expression between pre- and postmenopausal women in human vaginal tissues. Zinc transporter families are responsible for the maintenance of intracellular zinc concentrations. Zinc has significant effects on the extracellular matrix composition. Vaginal wall biopsies were obtained from seven premenopausal and seven postmenopausal women. mRNA expression of twenty-four zinc transporters was determined by quantitative real-time PCR. Zinc transporter expression at the protein level was assessed by immunohistochemistry. Student's t test and Mann-Whitney U test were used to compare data. ZnT4 and ZnT9 mRNA expression were significantly lower in postmenopausal women compared with premenopausal women (mean ? SD mRNA expression in relative units, 96.43 ? 140.61 vs. 410.59 ? 304.34, p = 0.03 and 0.62 ? 0.39 vs. 1.13 ? 0.31, p = 0.02). In addition, ZIP2, ZIP3, and ZIP6 mRNA expressions were significantly lower in postmenopausal women compared with premenopausal women (mean ? SD mRNA expression in relative units, 1.11 ? 0.61 vs. 2.29 ? 1.20, p = 0.04; 2.32 ? 1.90 vs. 15.82 ? 12.97, p = 0.02 and 1.10 ? 0.80 vs. 5.73 ? 4.72, p = 0.03). ZnT9 protein expression in the stratum spinosum was significantly lower in postmenopausal women (p = 0.012). Zinc transporters were expressed differentially in the vaginal tissues. ZnT9 expression was significantly lower in postmenopausal women compared with premenopausal women.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Gene expression
Menopause
Vagina
ZIPs
ZnTs
Megjelenés:Biological Trace Element Research. - 199 : 11 (2021), p. 4011-4019. -
További szerzők:Kozma Bence (1982-) (szülész-nőgyógyász) Pór Ágnes Kovács Ilona (1965-) (patológus) Lampé Rudolf (1983-) (szülész-nőgyógyász) Miklós Ida (1962-) (biológus) Takács Péter (1968-) (szülész-nőgyógyász)
Pályázati támogatás:GINOP-2.1.1-15-2016-00783
GINOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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